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Lee, Seungwon,Kim, Hyekang,You, Gihoon,Kim, Young-Min,Lee, Seunghun,Le, Viet-Hoan,Kwon, Ohseop,Im, Sin-Hyeog,Kim, You-Me,Kim, Kwang Soon,Sung, Young Chul,Kim, Ki Hean,Surh, Charles D.,Park, Yunji,Lee, American Society of Hematology 2019 Blood Vol.134 No.16
<B>Abstract</B><P>Lee and colleagues investigated the role of the intestinal microbiota in steady-state hematopoieisis, demonstrating that microbiota-derived DNA circulates to the bone marrow, where uptake by mononuclear cells leads to inflammatory cytokine production favoring myeloid-cell maturation of hematopoietic progenitors.</P>
Kim, Hyekang,Lee, Seungwon,Lee, Seung-Woo Korean Society for Molecular and Cellular Biology 2018 Molecules and cells Vol.41 No.8
Tumor necrosis factor receptor-associated factor 6 (TRAF6) is identified as a signaling adaptor protein that regulates bone metabolism, immunity, and the development of several tissues. Therefore, its functions are closely associated with multiple diseases. TRAF6 is also involved in the regulation of hematopoiesis under steady-state conditions, but the role of TRAF6 in modulating hematopoietic stem and progenitor cells (HSPCs) during the developmental stages remains unknown. Here, we report that the deletion of TRAF6 in hematopoietic lineage cells resulted in the upregulation of HSPCs in the fetal liver at the prenatal period. However, in the early postnatal period, deletion of TRAF6 drastically diminished HSPCs in the bone marrow (BM), with severe defects in BM development and extramedullary hematopoiesis in the spleen being identified. In the analysis of adult HSPCs in a BM reconstitution setting, TRAF6 played no significant role in HSPC homeostasis, albeit it affected the development of T cells. Taken together, our results suggest that the role of TRAF6 in regulating HSPCs is altered in a spatial and temporal manner during the developmental course of mice.
Kwon, Ohseop,Lee, Seungwon,Kim, Ji-Hae,Kim, Hyekang,Lee, Seung-Woo 한국조명·전기설비학회 2015 한국조명·전기설비학회 학술대회논문집 Vol. No.
<P>Hematopoietic stem and progenitor cells (HSPCs) can produce all kind of blood lineage cells, and gut microbiota that consists of various species of microbe affects development and maturation of the host immune system including gut lymphoid cells and tissues. However, the effect of altered gut microbiota composition on homeostasis of HSPCs remains unclear. Here we show that compositional change of gut microbiota affects homeostasis of HSPCs using <I>Rag1</I><SUP>-/-</SUP> mice which represent lymphopenic condition. The number and proportions of HSPCs in <I>Rag1</I><SUP>-/-</SUP> mice are lower compared to those of wild types. However, the number and proportions of HSPCs in <I>Rag1</I><SUP>-/-</SUP> mice are restored as the level of wild types through alteration of gut microbiota diversity via transferring feces from wild types. Gut microbiota composition of <I>Rag1</I><SUP>-/-</SUP> mice treated with feces from wild types shows larger proportions of family <I>Prevotellaceae</I> and <I>Helicobacterceae</I> whereas lower proportions of family <I>Lachnospiraceae</I> compared to unmanipulated <I>Rag1</I><SUP>-/-</SUP> mice. In conclusion, gut microbiota composition of lymphopenic <I>Rag1</I><SUP>-/-</SUP> mice is different to that of wild type, which may lead to altered homeostasis of HSPCs.</P>