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The Treatment of Pazopanib on Vulvar Epithelioid Sarcoma: A Case Report and Review of Literature
( Hye Won Chung ),( Chi Heum Cho ),( So Jin Shin ) 대한산부인과학회 2014 대한산부인과학회 학술대회 Vol.100 No.-
Epitheliod sarcoma of vulva is a very rare kind of tumor which its diagnosis cannot be readily reached; however, it is characterized by a variety of aggressive biological behaviors and poor prognosis. We report a case of vulvar epitheloid sarcoma in a 24?years-old woman who presented with protruding, mushrooms like mass on multiple area including lower abdomen, whole vulva, anus and both inguinal lesions along with distant metastasis to lung, pleura, bone and scalp. Result from histological evaluation showed malignant tumor, consistent with proximal type of epithelioid sarcoma. The main lesion was an open wound of large necrotic tissue formation with exposed bone on whole vulva. Her treatment started with palliative radiation therapy followed by adjuvant chemotherapy. Follow up imaging studies revealed a good response with partial resolution of vulvar lesion and complete resolution of pelvic bone metastasis. However, aggravation of multiple lung and pleural metastases was detected. Consequently the patient received target therapy of Pazopanib which is an inhibitor of vascular endothelial growth factor receptor (VEGFR) pathway. After two months of daily regimen of Pazopanib (400 mg) follow up imaging studies showed partial resolution of both lung and pleural metastases. Pazopanib plays a crucial role in distant metastasis of solid malignancies and brings a delay in progression of the disease.
The effect of salinomycin on ovarian cancer stem-like cells
( Hyewon Chung ),( Yu-hwan Kim ),( Myoung Kwon ),( So-jin Shin ),( Sang-hoon Kwon ),( Soon-do Cha ),( Chi-heum Cho ) 대한산부인과학회 2016 Obstetrics & Gynecology Science Vol.59 No.4
Objective The identification of cancer stem-like cells is a recent development in ovarian cancer. Compared to other cancer cells, cancer stem-like cells present more chemo-resistance and more aggressive characteristics. They play an important role in the recurrence and drug resistance of cancer. Therefore, the target therapy of cancer stem-like cell may become a promising and effective approach for ovarian cancer treatment. It may also help to provide novel diagnostic and therapeutic strategies. Methods The OVCAR3 cell line was cultured under serum-free conditions to produce floating spheres. The CD44+CD117+ cell line was isolated from the human ovarian cancer cell line OVCAR3 by using immune magnetic-activated cell sorting system. The expression of stemness genes such as OCT3/4, NANOG and SOX2 mRNA were determined by reverse transcription polymerase chain reaction. OVCAR3 parental and OVCAR3 CD44+CD117+ cells were grown in different doses of paclitaxel and salinomycin to evaluate the effect of salinomycin. And growth inhibition of OVCAR3 CD44+CD117+ cells by paclitaxel combined with salinomycin was determined by the 3-(4,5-dimethylthiazol-2-yl)-2,5- diphenyl-2H-tetrazolium bromide (MTT) assay. Results Tumor spheroids generated from the OVCAR3 cell line are shown to have highly enriched CD44 and CD117 expression. Treatment with a combination of paclitaxel and salinomycin demonstrated growth inhibition of OVCAR3 CD44+CD117+ cells. Conclusion The present study is a detailed investigation on the expression of CD44 and CD117 in cancer stem cells and evaluates their specific tumorigenic characteristics in ovarian cancer. This study also demonstrates significant growth inhibition of cancer stem-like cells by paclitaxel combined with salinomycin. Identification of these cancer stem-like cell markers and growth inhibition effect of salinomycin may be the next step to the development of novel target therapy in ovarian cancer.
( Hye Won Chung ),( Si Young Song ),( Jae Bock Chung ),( Yong Chan Lee ),( Byoung Soo Moon ) 대한소화기학회 2007 SIDDS Vol.9 No.-
Background/Aims: In order to identify a desirable serum marker for screening tools for gastric cancer, we evaluated the validity of three biomarkers, namely, carcinoembryonic antigen (CEA), pepsinogens (PGs), and high sensitive C-reactive protein (hsCRP). Methods: We estimated the mean serum levels of CEA, PGs, and hsCRP and compared the sensitivity and specificity of these three biomarkers in 378 subjects who were classified into seven groups: normal, chronic atrophic gastritis (CAG), intestinal metaplasia (IM), adenoma, early gastric cancer (EGC), advanced gastric cancer (AGC) without metastasis, and AGC with metastasis (M1). Results: There were no significant differences among the normal, high-risk (CAG, IM, adenoma), and EGC groups for CEA and hsCRP. However, the levels of CEA were relatively higher in the AGC group with intestinal-type cancer (P<0.01). Likewise, hsCRP was relatively higher in the AGC group with diffuse-type cancer (P<0.01). For the PG I/II ratio, there was no significant difference among the normal, high-risk, and cancer groups, including EGC (P<0.01). In addition, there was a negative correlation with grades (γ s=-0.48, p <0.01). However, the PG I/II ratio was, relatively less effective in diffuse-type cancer compared with intestinal-type cancer. The combination of serum hsCRP and the PG I/II ratio bad a higher sensitivity (77%) than did the PG I/II ratio alone (61%) in diffuse-type cancers. Conclusions: The combination of serum hsCRP and PG I/II ratio would be helpful as a screening tool for gastric cancer in high incidence populations and may help to select high-risk subjects in need of further specific invasive screening tools such as endoscopy.