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RISS 인기검색어
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- 저자 : Huiwen Guo (검색결과 2 건)
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Effect of Wall Structures on Mechanical Properties of Small Caliber PHBHHx Vascular Grafts
Jing Gao,Zhenzhen Huang,Huiwen Guo,Shunzhu Tian,Lu Wang,Yuling Li 한국섬유공학회 2019 Fibers and polymers Vol.20 No.11
In order to analyze the effect of vascular wall structures on static and dynamic mechanical properties of vasculargrafts, small calibre PHBHHx (Poly(3-hydroxybutyrate-co-3-hydroxhexanoate)) vascular grafts (inner diameter 6 mm) withvarious wall shapes and thicknesses were fabricated by changing electrospinning time and receiving molds. As spinning timeincreased, wall thickness of the vascular grafts increased and both circumferential tensile strength and suture retentionstrength improved significantly. When the wall thicknesses of straight grafts were about 120 μm, the great radial dynamiccompliance was exhibited, however, the tensile strength and suture retention strength of the straight tubes can’t reach therequirements of normal blood vessel grafting. With the wall thicknesses increasing above 250 μm, although thecircumferential tensile strength and suture retention strength gradually achieved the transplanting requirements, the dynamiccompliance of the straight tubes declined too sharply to adapt the blood radial shock. For corrugated grafts, the effect of wallthickness on radial dynamic compliance was little, and the radial dynamic compliance was close to that of the commercialvascular grafts. The circumferential tensile strength and suture retention strength of the corrugated grafts were also improvedto approach the commercial vessels’ performances with the wall thickness improving to about 425 μm. Elastic recovery ratesof all the prepared vascular grafts were superior to that of the commercial sample. Along with the wall thickness exceeding250 μm, the water permeabilities of both the straight and the corrugated grafts were less than 300 ml/(cm2·min).
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Wnt pathway is involved in 5-FU drug resistance of colorectal cancer cells
Lingfeng He,Hong Zhu,Shiying Zhou,Ting Wu,Huan Wu,Huan Yang,Huiwen Mao,Chandra SekharKathera,Avilala Janardhan,Ashlin M. Edick,Anna Zhang,Zhigang Hu,Feiyan Pan,Zhigang Guo 생화학분자생물학회 2018 Experimental and molecular medicine Vol.50 No.-
Colorectal cancer (CRC) is one of the leading causes of cancer-related death worldwide. 5-Fluorouracil (5-FU) is widely used in the treatment of cancers, but its antineoplastic activity is limited in drug-resistant cancer cells. To investigate the detailed mechanism of 5-FU resistance, we developed a model of 5-FU-resistant cells from HCT-8 cells, a wellestablished colorectal cancer cell line. We found that the drug-resistant cells demonstrated high expression of TCF4 and β-catenin, indicating an upregulated Wnt pathway. A microarray analysis revealed that the suppression of the checkpoint kinase 1 (CHK1) pathway explained the resistance to 5-FU, especially in p53 wild-type cancer cells such as HCT-8. Our data also demonstrated that the CHK1 pathway is suppressed by the Wnt pathway in 5-FU-resistant cells. In summary, we have discovered a novel mechanism for 5-FU resistance mediated by histone deacetylation, which also revealed the crosstalk between the Wnt pathway and CHK1 pathway.
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