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Fatigue Resistance of a BFRP-Encapsulated Long-Gauge FBG Strain Sensor under Cyclic Train Loads
Bi-tao Wu,Yujian Zhou,Huaxi Lu,Yunhuang Xiao,Zhenwei Zhou 대한토목학회 2022 KSCE JOURNAL OF CIVIL ENGINEERING Vol.26 No.9
To verify the performance of a basalt fiber reinforced polymer (BFRP) fiber-encapsulated long-gauge strain sensor in railway bridge health monitoring, this paper studies the fatigue resistance and durability of the BFRP fiber-encapsulated FBG sensor under train loads. First, the influences of the length of the anchorage section and the length ratio of the sensing section on the accuracy of the sensor were studied. Then, the BFRP sensor was applied to a sleeper for 2 million cycles of tension fatigue testing. The strain-time history of the whole fatigue test was monitored and compared. After the test, a calibration test was carried out to verify the accuracy and repeatability of the sensor. Finally, the slip and fatigue cracking of the fiber in the anchorage section of the sensor were observed by electron microscopy. The results show that the gap between the anchoring section and the bare optical fiber was filled with epoxy resin, and there was no slip behavior. No fatigue cracking occurred in the fiber, and the straincoefficient and linearity of the sensor showed no obvious changes after 2 million cycles of loading. The long-gauge strain sensor encapsulated by BFRP fibers exhibited good fatigue resistance and can meet long-term monitoring requirements under train loads.
Intracellular trafficking of TREM2 is regulated by presenilin 1
Yingjun Zhao,Xiaoguang Li,Timothy Huang,Lu-lin Jiang,Zhenqiu Tan,Muxian Zhang,Irene Han-Juo Cheng,Xin Wang,Guojun Bu,Yun-wu Zhang,Qi Wang,Huaxi Xu 생화학분자생물학회 2017 Experimental and molecular medicine Vol.49 No.-
Genetic mutations in triggering receptor expressed on myeloid cells 2 (TREM2) have been linked to a variety of neurodegenerative diseases including Alzheimer’s disease, amyotrophic lateral sclerosis, frontotemporal dementia and Parkinson’s disease. In the brain, TREM2 is highly expressed on the cell surface of microglia, where it can transduce signals to regulate microglial functions such as phagocytosis. To date, mechanisms underlying intracellular trafficking of TREM2 remain elusive. Mutations in the presenilin 1 (PS1) catalytic subunit of the γ-secretase complex have been associated with increased generation of the amyloidogenic Aβ (amyloid-β) 42 peptide through cleavage of the Aβ precursor amyloid precursor protein. Here we found that TREM2 interacts with PS1 in a manner independent of γ-secretase activity. Mutations in TREM2 alter its subcellular localization and affects its interaction with PS1. Upregulation of PS1 reduces, whereas downregulation of PS1 increases, steady-state levels of cell surface TREM2. Furthermore, PS1 overexpression results in attenuated phagocytic uptake of Aβ by microglia, which is reversed by TREM2 overexpression. Our data indicate a novel role for PS1 in regulating TREM2 intracellular trafficking and pathophysiological function.