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- 저자 : Huang Tianqi (검색결과 3 건)
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Huang Tianqi,Zhao Dong,Lee Sangbin,Keum Gyochang,Yang Hyun Ok 한국응용약물학회 2023 Biomolecules & Therapeutics(구 응용약물학회지) Vol.31 No.3
Sinapic acid (SA) is a phenolic acid that is widely distributed in fruits and vegetables, which has various bioactivities, such as antidiabetic, anticancer and anti-inflammatory functions. Over-activated microglial is involved in the development progress of neurodegenerative diseases, such as Parkinson’s disease and Alzheimer’s disease. The objective of this study was to investigate the effect of SA in microglia neuroinflammation models. Our results demonstrated that SA inhibited secretion of the nitric oxide (NO) and interleukin (IL)-6, reduced the expression of inducible nitric oxide synthase (iNOS) and enhanced the release of IL-10 in a dose-dependent manner. Besides, our further investigation revealed that SA attenuated the phosphorylation of AKT and MAPK cascades in LPS-induced microglia. Consistently, oral administration of SA in mouse regulated the production of inflammationrelated cytokines and also suppressed the phosphorylation of MAPK cascades and AKT in the mouse cerebral cortex. These results suggested that SA may be a possible therapy candidate for anti-inflammatory activity by targeting the AKT/MAPK signaling pathway.
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Damping Applications of Ferrofluids
Chuan Huang,Jie Yao,Tianqi Zhang,Yibiao Chen,Huawei Jiang,Decai Li 한국자기학회 2017 Journal of Magnetics Vol.22 No.1
Ferrofluids are a special category of smart nanomaterials which shows normal liquid behavior coupled with superparamagnetic properties. One of the earliest and most prospective applications of ferrofluids is in damping, which has prominent advantages compared with conventional damping devices: simplicity, flexibility and reliability. This paper presents the basic principles that play a major role in the design of ferrofluid damping devices. The characteristics of typical ferrofluid damping devices including dampers, vibration isolators, and dynamic vibration absorbers are compared and summarized, and then recent progress of vibration energy harvesters based on ferrofluid is briefly described. Additionally, we proposed a novel ferrofluid dynamic vibration absorber in this paper, and its damping efficiency was verified with experiments. In the end, the critical problems and research directions of the ferrofluid damping technology in the future are raised.
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Long Qichen,Qi Tianqi,Zhang Tianjiao,Wang Jing,Zeng Jie,Ying Yan,Meng Wang,Wei Huang,Haijian Zhao,Wenxiang Chen,Chuanbao Zhang 대한진단검사의학회 2021 Annals of Laboratory Medicine Vol.41 No.1
Background: Using commutable external quality assessment (EQA) materials is important for monitoring successful harmonization efforts. We assessed the commutability of four human serum pool (HSP) preparations to identify candidate EQA materials for alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activity measurement. Methods: One set each of 85 clinical samples (CSs) was collected for ALT and AST activity measurement. The 15 candidate EQA materials included four types of HSP preparations (A to D): materials A, C, and D contained human original recombinant (HOR) aminotransferases; materials B was mixed leftover samples. The CSs and 15 candidate EQA materials were analyzed using seven routine assays, and the ln-transformed results were analyzed in 21 assay pairs. Commutability was assessed using Deming regression, with a 95% prediction interval (CLSI approach) and the difference in bias with an error component model (International Federation of Clinical Chemistry and Laboratory Medicine [IFCC] approach). Results: For ALT, all materials were commutable for 14–21 assay pairs according to the CLSI and IFCC approaches. For AST, B01-03 showed commutability for 14-21 assay pairs, and C01-03 and D01-03 showed commutability for no less than 10 assay pairs according to the two approaches. A01-06 were commutable for 9-16 assay pairs according to the CLSI approach, but for 6-9 assay pairs according to the IFCC approach. Conclusions: Mixed leftover samples showed desirable commutability characteristics as candidate EQA materials for routine aminotransferase activity measurements. Human serum bases supplemented with HOR were commutable for most routine ALT activity measurements.
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