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Zhang, Huai-Min,Yang, Hao,Wu, Lan-Zhi,Song, Shuang,Yang, Li-Rong Korean Chemical Society 2012 Bulletin of the Korean Chemical Society Vol.33 No.11
Three kinds of 3D isomorphous and isostructural coordination polymers, namely, $\{[Ln_2(PDA)_3(H_2O)_3]{\cdot}0.25H_2O\}_{\infty}$ (Ln = La(1), Sm(2), and Gd(3)) ($PDA^{2-}$ = pyridine-2,6-dicarboxylate anion) have been synthesized under hydrothermal conditions and characterized by elemental analyses, IR spectroscopy, thermal analyses and single crystal X-ray diffraction. In these MOFs, Ln(III) centers adopt eight-coordinated and nine-coordinated with the $N_1O_7$ and $N_2O_7$ donor sets to construct distorted trianglar dodecahedron geometry and tricapped trigonal prism configurations, respectively. Based on the building block of tetranuclear homometallic $Ln_4C_4O_8$ unit (16-membered ring), 1-3 are connected into highly ordered 2D sheets via O-C-O linkers and further constructed into 3D architectures through hydrogen bonds. Crystallographic parameters suggest that the lanthanide contraction effect exist in these coordination polymers. Luminescent properties of the lanthanide-based MOFs (metal-organic frameworks) have been measured at room temperature, which reveal that they presenting ionselective characters toward certain metals, such as $Mg^{2+}$, $Cd^{2+}$ and $Pb^{2+}$ ions.
Huai-min Zhang,Hao Yang,Lan-zhi Wu,Shuang Song,Li-rong Yang 대한화학회 2012 Bulletin of the Korean Chemical Society Vol.33 No.11
Three kinds of 3D isomorphous and isostructural coordination polymers, namely, {[Ln2(PDA)3(H2O)3]·0.25H2O}∞ (Ln = La(1), Sm(2), and Gd(3)) (PDA2− = pyridine-2,6-dicarboxylate anion) have been synthesized under hydrothermal conditions and characterized by elemental analyses, IR spectroscopy, thermal analyses and single crystal X-ray diffraction. In these MOFs, Ln(III) centers adopt eight-coordinated and nine-coordinated with the N1O7 and N2O7 donor sets to construct distorted trianglar dodecahedron geometry and tricapped trigonal prism configurations, respectively. Based on the building block of tetranuclear homometallic Ln4C4O8 unit (16- membered ring), 1-3 are connected into highly ordered 2D sheets via O-C-O linkers and further constructed into 3D architectures through hydrogen bonds. Crystallographic parameters suggest that the lanthanide contraction effect exist in these coordination polymers. Luminescent properties of the lanthanide-based MOFs (metal-organic frameworks) have been measured at room temperature, which reveal that they presenting ionselective characters toward certain metals, such as Mg2+, Cd2+ and Pb2+ ions.
Tas13D Inhibits Growth of SMMC-7721 Cell via Suppression VEGF and EGF Expression
He, Huai-Zhen,Wang, Nan,Zhang, Jie,Zheng, Lei,Zhang, Yan-Min Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.5
Objective: Taspine, isolated from Radix et Rhizoma Leonticis has demosntrated potential proctiective effects against cancer. Tas13D, a novel taspine derivative synthetized by structure-based drug design, have been shown to possess interesting biological and pharmacological activities. The current study was designed to evaluate its antiproliferative activity and underlying mechanisms. Methods: Antiproliferative activity of tas13D was evaluated by xenograft in athymic mice in vivo, and by 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide (MTT) and cell migration assays with human liver cancer (SMMC-7721) cell lines in vitro. Docking between tas13D and VEGFR and EGFR was studied by with a Sybyl/Surflex module. VEGF and EGF and their receptor expression was determined by ELISA and real-time PCR methods, respectively. Results: Our present study showed that tas13D inhibited SMMC-7721 xenograft tumor growth, bound tightly with the active site of kinase domains of EGFR and VEGFR, and reduced SMMC-7721 cell proliferation (IC=34.7 ${\mu}mol/L$) and migration compared to negative controls. VEGF and EGF mRNAs were significantly reduced by tas13D treatment in a dose-dependent manner, along with VEGF and EGF production. Conclusion: The obtained results suggest that tas13D inhibits tumor growth and cell proliferation by inhibiting cell migration, downregulating mRNA expression of VEGF and EGF, and decreasing angiogenic factor production. Tas13D deserves further consideration as a chemotherapeutic agent.
Further Analyzing the Sybil Attack in Mitigating Peer-to-Peer Botnets
( Tian-zuo Wang ),( Huai-min Wang ),( Bo Liu ),( Bo Ding ),( Jing Zhang ),( Pei-chang Shi ) 한국인터넷정보학회 2012 KSII Transactions on Internet and Information Syst Vol.6 No.10
Sybil attack has been proved effective in mitigating the P2P botnet, but the impacts of some important parameters were not studied, and no model to estimate the effectiveness was proposed. In this paper, taking Kademlia-based botnets as the example, the model which has the upper and lower bound to estimate the mitigating performance of the Sybil attack is proposed. Through simulation, how three important factors affect the performance of the Sybil attack is analyzed, which is proved consistent with the model. The simulation results not only confirm that for P2P botnets in large scale, the Sybil attack is an effective countermeasure, but also imply that the model can give suggestions for the deployment of Sybil nodes to get the ideal performance in mitigating the P2P botnet.
Liu, Liu,Fan, Yan-Hua,Wu, Lan-Zhi,Zhang, Huai-Min,Yang, Li-Rong Korean Chemical Society 2013 Bulletin of the Korean Chemical Society Vol.34 No.12
Two 3D isomorphous and isostructural complexes, namely, $[Zn(BDOA)(bpy)(H_2O)_2]_n$ (1) and $[Cd(BDOA)-(bpy)(H_2O)_2]_n$ (2); (BDOA = Benzene-1,4-dioxyacetic acid, bpy = 4,4'-bipyridine) were synthesized under hydrothermal conditions and characterized by means of elemental analyses, thermogravimetric (TG), infrared spectrometry, and single crystal X-ray diffraction. Complexes 1 and 2 crystallize in the triclinic system, space group P-1 and each metal ion in the complexes are six-coordinated with the same coordination environment. In the as-synthesized complexes, $BDOA^{2-}$ anions link central metal ions to form a 1D zigzag chain $[-BDOA^{2-}-Zn(Cd)-BDOA^{2-}-Zn(Cd)-]_{\infty}$, whereas bpy pillars connect metal ions to generate a 1D linear chain $[-bpy-Zn(Cd)-bpy-Zn(Cd)-]_{\infty}$. Both infinite chains are interweaved into 2D grid-like layers which are further constructed into a 3D open framework, where hydrogen bonds play as the bridges between the adjacent 2D layers. Luminescent properties of complex 1 showed selectivity for $Hg^{2+}$ ion.
Liu Liu,Yan-hua Fan,Lan-zhi Wu,Huai-min Zhang,Li-rong Yang 대한화학회 2013 Bulletin of the Korean Chemical Society Vol.34 No.12
Two 3D isomorphous and isostructural complexes, namely, [Zn(BDOA)(bpy)(H2O)2]n (1) and [Cd(BDOA)- (bpy)(H2O)2]n (2); (BDOA = Benzene-1,4-dioxyacetic acid, bpy = 4,4'-bipyridine) were synthesized under hydrothermal conditions and characterized by means of elemental analyses, thermogravimetric (TG), infrared spectrometry, and single crystal X-ray diffraction. Complexes 1 and 2 crystallize in the triclinic system, space group P-1 and each metal ion in the complexes are six-coordinated with the same coordination environment. In the as-synthesized complexes, BDOA2− anions link central metal ions to form a 1D zigzag chain [-BDOA2− -Zn(Cd)-BDOA2−-Zn(Cd)-]∞, whereas bpy pillars connect metal ions to generate a 1D linear chain [-bpy- Zn(Cd)-bpy-Zn(Cd)-]∞. Both infinite chains are interweaved into 2D grid-like layers which are further constructed into a 3D open framework, where hydrogen bonds play as the bridges between the adjacent 2D layers. Luminescent properties of complex 1 showed selectivity for Hg2+ ion.