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KIM, JIN-AH,KIM, DONG HWAN,HOSSAIN, MOHAMMAD AKBAR,KIM, MIN YOUNG,SUNG, BOKYUNG,YOON, JEONG-HYUN,SUH, HONGSUK,JEONG, TAE CHEON,CHUNG, HAE YOUNG,KIM, NAM DEUK Spandidos Publications 2014 International journal of oncology Vol.44 No.2
Resveratrol, a polyphenolic compound, is a naturally occurring phytochemical and is found in a variety of plants, including food such as grapes, berries and peanuts. It has gained much attention for its potential anticancer activity against various types of human cancer. However, the usefulness of resveratrol as a chemotherapeutic agent is limited by its photosensitivity and metabolic instability. In this study the effects of a synthetic analogue of resveratrol, HS-1793, on the proliferation and apoptotic cell death were investigated using MCF-7 (wild-type p53) and MDA-MB-231 (mutant p53) human breast cancer cells. HS-1793 inhibited cell growth and induced apoptotic cell death in a concentration-dependent manner. The induction of apoptosis was determined by morphological changes, cleavage of poly(ADP-ribose) polymerase, alteration of Bax/Bcl-2 expression ratio and caspase activities. Flow cytometric analysis revealed that HS-1793 induced G2/M arrest in the cell cycle progression in both types of cells. Of note, HS-1793 induced p53/p21(WAF1/CIP1)-dependent apoptosis in MCF-7 cells, whereas it exhibited p53-independent apoptosis in MDA-MB-231 cells. Furthermore, HS-1793 showed more potent anticancer effects in several aspects compared to resveratrol in MCF-7 and MDA-MB-231 cells. Thus, these findings suggest that HS-1793 has potential as a candidate chemotherapeutic agent against human breast cancer.
Peugeot 607 경유승용차의 매연여과장치 특성 분석
김홍석(Hongsuk Kim),김진현(Jinhyun Kim),신동길(Dongkil Shin),조규백(Gyubaek Cho),정용일(Youngil Jeong),김강출(Gangchul Kim),이영재(Youngjae Lee) 한국자동차공학회 2004 한국 자동차공학회논문집 Vol.12 No.3
DPF technology has been considered as one of the most effective methods for reducing diesel particulate emisson. PSA Peugeot Citroen introduced the DPF equipped diesel passenger car, Peugeot 607 HDI Sedan, in 2000 for the first time in the world, in which Sic filter, an oxidation catalyst, cerium based fuel born catalyst and post-injection technology were used for PM regeneration. In the present study, the characteristics of the Peugeot 607 DPF system were studied on chassis dynamometer and real road driving conditions. The change of emissons and fuel economy during 80,000km operation were also tested. Additionally, ash contents accumulated in the DPF filter was analyzed and particle size distributions was investigated after running of 80,000km.
( Jin Ah Kim ),( Dong Hwan Kim ),( Mohammad Akbar Hossain ),( Min Young Kim ),( Bokyung Sung ),( Jeong Hyun Yoon ),( Hongsuk Suh ),( Tae Cheon Jeong ),( Hae Yong Chung ),( Nam Deuk Kim ) 영남대학교 약품개발연구소 2014 영남대학교 약품개발연구소 연구업적집 Vol.24 No.0
Resveratrol, a polyphenolic compound, is a naturally occurring phytochemical and is found in a variety of plants, including food such as grapes, berries and peanuts. It has gained much attention for its potential anticancer activity against various types of human cancer. However, the usefulness of resveratrol as a chemotherapeutic agent is limited by its photosensitivity and metabolic instability. In this study the effects of a synthetic analogue of resveratrol, HS-1793, on the proliferation and apoptotic cell death were investigated using MCF-7 (wild-type p53) and MDA-MB-231 (mutant p53) human breast cancer cells. HS-1793 inhibited cell growth and induced apoptotic cell death in a concentration-dependent manner. The induction of apoptosis was determined by morphological changes, cleavage of poly(ADP-ribose) poly-merase, alteration of Bax/Bcl-2 expression ratio and caspase activities. Flow cytometric analysis revealed that HS-1793 induced G2/M arrest in the cell cycle progression in both types of cells. Of note, HS-1793 induced p53/p21WAF1/CIP1-dependent apoptosis in MCF-7 cells, whereas it exhibited p53-independent apoptosis in MDA-MB-231 cells. Furthermore, HS-1793 showed more potent anticancer effects in several aspects compared to resveratrol in MCF-7 and MDA-MB-231 cells. Thus, these findings suggest that HS-1793 has potential as a candidate chemotherapeutic agent against human breast cancer.
Kim, Dong Hwan,Kim, Min Jeong,Sung, Bokyung,Suh, Hongsuk,Jung, Jee H.,Chung, Hae Young,Kim, Nam Deuk Spandidos Publications 2017 ONCOLOGY REPORTS Vol.37 No.1
<P>Resveratrol, a polyphenolic compound, is a naturally occurring phytochemical and is found in a variety of plants, including grapes, berries and peanuts. It has gained much attention for its potential anticancer activity against various types of human cancer. However, the usefulness of resveratrol as a chemotherapeutic agent is limited by its photosensitivity and metabolic instability. In this study the effects of a synthetic analogue of resveratrol, HS-1793, on the proliferation and apoptotic cell death were investigated using HCT116 human colon cancer cells. Although this compound has been reported to have anticancer activities in several human cancer cell lines, the therapeutic effects of HS-1793 on human colon cancer and its mechanisms of action have not been extensively studied. HS-1793 inhibited cell growth and induced apoptotic cell death in a concentration-dependent fashion. Induction of apoptosis was determined by morphological changes, cleavage of poly(ADP-ribose) polymerase, alteration of Bax/Bcl-2 expression ratio, and caspase activations. Flow cytometric analysis revealed that HS-1793 induced G2/M arrest in the cell cycle progression in HCT116 cells. Furthermore, HS-1793 showed more potent anticancer effects in several aspects than resveratrol in HCT116 cells. In addition, HS-1793 suppressed Akt and the phosphatidylinositol-3 kinase/Akt inhibitor LY294002 was found to enhance its induction of apoptosis. Thus, these findings suggest that HS-1793 have potential as a candidate chemotherapeutic agent against human colon cancer.</P>
Microheater based on magnetic nanoparticle embedded PDMS
Kim, Jeong Ah,Lee, Seung Hwan,Park, Hongsuk,Kim, Jong Hyo,Park, Tai Hyun IOP Pub 2010 Nanotechnology Vol.21 No.16
<P>A microheater was established by embedding magnetic nanoparticles into PDMS (MNP-PDMS). MNP-PDMS generated heat under an AC magnetic field and the temperature was controlled by varying the magnetic particle content and the magnetic field intensity. In this study, the MNP-PDMS chip was demonstrated to amplify the target DNA (732 bp) with > 90% efficiency compared to the conventional PCR thermocycler, and exhibited good performance in regards to temperature control. This system holds great promise for reliably controlling the temperature of thermal processes on an integrated microchip platform for biochemical applications. </P>
Quantitative analysis of vehicle particle emission by using calibrated CPC system
Hongsuk Kim,이진욱 대한기계학회 2011 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.25 No.11
Particle size distribution and particle number concentration from diesel engines are subjects of significant environmental concerns especially in the EU. A few years ago, the UN-ECE PMP proposed a method for measuring particle emissions in the diluted exhaust of internal combustion engine vehicles, which has become a key method used in new dilution systems and sampling condition. This paper describes the effects of parameters such as condensation particle counter (CPC) according to test procedures, test fuel and vehicle test mode, including NEDC and CVS-75 mode. The main results obtained from this study can be summarized as follows: (1) Periodic calibration of the CPC system is essential because the long-term usage of a CPC leads to an underestimation in the measurements of small particles. (2) Particle emissions measured by the UN-ECE PMP method were found to exhibit comparable repeatability as compared to other regulated emissions. (3) In particle number concentration emitted from different-fueled vehicles, the sources of particle emissions in an ascending order of magnitude are as follows: DPF equipped diesel passenger vehicles, gasoline and LPG fueled vehicles, and DPF unequipped diesel passenger vehicles. Also, we found that the particle numbers of DPF equipped diesel passenger vehicles, gasoline and LPG-fueled vehicles can meet the EU regulation limit (<6.0×10^11#/km), while DPF unequipped diesel passenger vehicles do not meet the EU limit.