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RISS 인기검색어
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- 저자 : Hongling Zheng (검색결과 5 건)
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Chunlong Deng,Yimin Shao,Hongling Zheng,Minggang Du,Yang Yang 제어로봇시스템학회 2018 제어로봇시스템학회 국제학술대회 논문집 Vol.2018 No.10
Pitting fault is easily observed in gear system, dynamics models are commonly established to study the vibration characteristics affected by pitting fault. However, most of the dynamics models ignore the elastohydrodynamic lubrication (EHL) in gear system, which plays an important role in early fatigue failure of gears. Therefore, a dynamics model is proposed to study the vibration characteristics of spur gear system with pitting fault based on the three-dimensional line contact elastohydrodynamic lubrication (3D-EHL) model. In this model, both the transverse torsional dynamics model with gear pitting fault and the 3D-EHL model are coupled through an iterative method. Firstly, the transient rolling and sliding velocity, radius of curvature, and dynamic tooth force will be calculated based on the transverse torsional dynamics model, and which are then applied in the 3D-EHL model to perform contact analysis on a single continuously meshing teeth pair. Secondly, the transient pressure and film thickness distribution calculated based on the 3D-EHL model are used to determine the rolling, sliding friction, and viscous damping of the gear pair. After that, these parameters are substituted into the dynamics model to obtain the vibration characteristics of gear system with pitting fault. Finally, different working conditions are compared based on the proposed model, the results show that the EHL has an effect on the vibration characteristics of gear system with pitting fault.
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Yan Zhang,Bing Ye,Hongling Zheng,Wei Zhang,Lin Han,Peng Yuan,Chao Zhang 대한천식알레르기학회 2019 Allergy, Asthma & Immunology Research Vol.11 No.6
Background: Exposure to organic dust has been widely investigated as a potential risk factor for asthma with different results. To clarify a potential relationship, we performed the present meta-analysis to integrate the results of studies examining the association of organic dust exposure with asthma. Methods: A comprehensive literature search in the electronic databases including EMBASE, PubMed and Cochrane Library databases (up to August 2018) was conducted. The adjusted odds ratios (ORs) with corresponding 95% confidence interval (CI) for organic dust exposure and asthma were retrieved and pooled to generate summary effect estimates in Revman 5.2. Results: Database searches retrieved 1,016 records. A total of 17 studies containing 3,619 cases and 6,585 controls were finally included in our meta-analysis. The summary estimates suggested that organic dust exposure was positively associated with asthma (OR, 1.48; 95% CI, 1.26–1.75; P < 0.00001), whether among population-based case-control studies (OR, 1.24; 95% CI, 1.13–1.35; P < 0.00001) or hospital-based case-control studies (OR, 2.79; 95% CI, 1.27–6.12; P = 0.01). Subgroup analysis showed that paper/wood (OR, 1.62; 95% CI, 1.38–1.90; P < 0.00001), flour/grain (OR, 1.48; 95% CI, 1.11–1.97; P = 0.008), and textile dust (OR, 1.50; 95% CI, 1.08–2.09; P = 0.02) exposure were significantly associated with asthma. Conclusions: Based on the studies evaluated, our meta-analysis results prompt that organic dust exposure is a risk factor inducing asthma, although precise analysis focus on specific organic dust materials is still warranted.
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The effective mechanism of the polysaccharides from Panax ginseng on chronic fatigue syndrome
Wang, Jia,Sun, Chengxin,Zheng, Yan,Pan, Hongling,Zhou, Yifa,Fan, Yuying 대한약학회 2014 Archives of Pharmacal Research Vol.37 No.4
Ginseng acidic polysaccharide WGPA isolated from the root of Panax ginseng C. A. Meyer was fractionated into WGPA-A and WGPA-N by anion-exchange chromatography. The antifatigue activity of ginseng acidic polysaccharide WGPA has been reported in our previous research. This present study was designed to identify its active component and elucidate the mechanism for preventing chronic fatigue syndrome (CFS). WGPA, WGPA-A and WGPA-N were orally administered to mice once daily for 15 days. The effects of these compounds on physiological biomarkers of oxidative stress and on the morphology of the mitochondria in striated skeletal muscle were assessed. The results of forced swimming test-induced indicated that WGPA and WGPA-A could lengthen the swimming time, while WGPA-N could not. In addition, malondialdehyde and lactate dehydrogenase levels in serum were enhanced; while those of superoxide dismutase and glutathione peroxidase were lowered. Interestingly, the structural degeneration of mitochondria were all ameliorated. These findings suggested that WGPA-A is the active component of WGPA, it might have potential therapeutic effects for CFS and the oxidative stress might be involved in the pathogenesis. Our results also provided essential data for a better understanding of the antifatigue effects of P. ginseng extracts.
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The effective mechanism of the polysaccharides from Panax ginseng on chronic fatigue syndrome
Jia Wang,Chengxin Sun,Yan Zheng,Hongling Pan,Yifa Zhou,Yuying Fan 대한약학회 2014 Archives of Pharmacal Research Vol.37 No.4
Ginseng acidic polysaccharide WGPA isolatedfrom the root of Panax ginseng C. A. Meyer was fractionatedinto WGPA-A and WGPA-N by anion-exchangechromatography. The antifatigue activity of ginseng acidicpolysaccharide WGPA has been reported in our previousresearch. This present study was designed to identify itsactive component and elucidate the mechanism for preventingchronic fatigue syndrome (CFS). WGPA, WGPAAand WGPA-N were orally administered to mice oncedaily for 15 days. The effects of these compounds onphysiological biomarkers of oxidative stress and on themorphology of the mitochondria in striated skeletal musclewere assessed. The results of forced swimming testinducedindicated that WGPA and WGPA-A couldlengthen the swimming time, while WGPA-N could not. Inaddition, malondialdehyde and lactate dehydrogenase levelsin serum were enhanced; while those of superoxidedismutase and glutathione peroxidase were lowered. Interestingly, the structural degeneration of mitochondriawere all ameliorated. These findings suggested thatWGPA-A is the active component of WGPA, it might havepotential therapeutic effects for CFS and the oxidative stress might be involved in the pathogenesis. Our resultsalso provided essential data for a better understanding ofthe antifatigue effects of P. ginseng extracts.
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CRISPR as a strong gene editing tool
( Shengfu Shen ),( Tiing Jen Loh ),( Hongling Shen ),( Xuexiu Zheng ),( Haihong Shen ) 생화학분자생물학회(구 한국생화학분자생물학회) 2017 BMB Reports Vol.50 No.1
Clustered regularly-interspaced short palindromic repeats (CRISPR) is a new and effective genetic editing tool. CRISPR was initially found in bacteria to protect it from virus invasions. In the first step, specific DNA strands of virus are identified by guide RNA that is composed of crRNA and tracrRNA. Then RNAse III is required for producing crRNA from pre-crRNA. In The second step, a crRNA:tracrRNA:Cas9 complex guides RNase III to cleave target DNA. After cleavage of DNA by CRISPR-Cas9, DNA can be fixed by Non- Homologous End Joining (NHEJ) and Homology Directed Repair (HDR). Whereas NHEJ is simple and random, HDR is much more complex and accurate. Gene editing by CRISPR is able to be applied to various biological field such as agriculture and treating genetic diseases in human. [BMB Reports 2017; 50(1): 20-24]
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