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Molecular and Clinicopathological Features of Gastrointestinal Stromal Tumors in Vietnamese Patients
Quoc Dat Ngo,Quoc Thang Pham,Dang Anh Thu Phan,Anh Vu Hoang,Thi Ngoc Ha Hua,Sao Trung Nguyen 대한병리학회 2019 Journal of Pathology and Translational Medicine Vol.53 No.6
Background: Gastrointestinal stromal tumors (GISTs) are the most frequent mesenchymal neoplasms of the gastrointestinal tract. Management of GIST patients is currently based on clinicopathological features and associated genetic changes. However, the detailed characteristics and molecular genetic features of GISTs have not yet been described in the Vietnamese population. Methods: We first identified 155 patients with primary GIST who underwent surgery with primary curative intent between 2011 and 2014 at University Medical Center at Ho Chi Minh City, Vietnam. We evaluated the clinicopathological features and immunohistochemical reactivity to p53 and Ki-67 in these patients. Additionally, KIT genotyping was performed in 100 cases. Results: The largest proportion of GISTs was classified as high-risk (43.2%). Of the 155 GISTs, 52 (33.5%) were positive for Ki-67, and 58 (37.4%) were positive for p53. The expression of Ki-67 and p53 were correlated with mitotic rate, tumor size, risk assessment, and tumor stage. Out of 100 GIST cases, KIT mutation was found in 68%, of which 62 (91.2%) were found in exon 11, two (2.9%) in exon 9, and four (5.8%) in exon 17. No mutation in exon 13 was identified. Additionally, KIT mutations did not correlate with any clinicopathological features. Conclusions: The expression of Ki-67 and p53 were associated with high-risk tumors. Mutations in exon 11 were the most commonly found, followed by exon 17 and exon 9. Additionally, KIT mutation status was not correlated with any recognized clinicopathological features.
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Huan Quang NGO,Thang Quyet NGUYEN,Nguyen Thanh LONG,Tung Van TRAN,Tri M. HOANG 한국유통과학회 2019 The Journal of Asian Finance, Economics and Busine Vol.6 No.3
The paper aims to examine the factors affecting brand and student decision in buying fresh milk. Combining qualitative and quantitative research methods, this study used self-completed questionnaires to investigate 520 students in Ho Chi Minh City. The results of the study show that that there are five key determinants affecting the dairy brand and student decision in buying fresh milk, including: (1) product quality, (2) fair price, (3) product promotion and customer services, (4) product convenience, and (5) reference group’s attitude to the brand. In addition, it is also found that product brand has a direct and positive impact on the student decision. The finding in this study is quite different from other existing literatures in terms of the importance level of the determinants of the student decision in buying fresh milk; specifically, in deciding to buy their fresh milk, students are often interested in the promotion and customer service, the product convenience, and the reference group for the purchase, more than in the quality and price of the product. From these findings, some managerial implications are proposed for policy-makers and relevant enterprises to have appropriate policies and strategies for their business development.
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Trong Luan NGUYEN,Nguyen Anh Ngu PHAM,Thi Kim Nhung NGUYEN,Ngoc Khai Vy NGUYEN,Hoang Thang NGO,Tran Thien Ly PHAM 한국유통과학회 2022 The Journal of Asian Finance, Economics and Busine Vol.9 No.2
At present, environmental problems are gradually becoming quite serious because of the expansion of the business scale of companies, factories, and enterprises, and that is also the reason for the global pollution of the world. Green entrepreneurship is playing an increasingly crucial role in influencing people’s intentions, behaviors, and attitudes toward environmental protection through sustainable development. The purpose of this research was to examine the factors affecting university students’ green entrepreneurship levels in Vietnam. To do this, we performed a scientific research survey with 773 students from reputable universities in Vietnam, 337 of whom are male and 436 of whom are female. To assess the reliability and correlation between observed and total variables, this study employs scale testing methods such as Cronbach alpha, EFA, CFA, and SEM. After evaluating the influencing elements, the findings reveal that the Subjective norm factor and the Risk-aversion component are two distinct aspects that influence university students’ green entrepreneurship intentions in Vietnam and of which, the greatest influence is Risk Aversion. Furthermore, the findings revealed that the level of interest in green entrepreneurship is mostly seen by students with university education between the ages of 18–25.
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Thi Binh Nguyen Nguyen,Thi Kieu Diem Nguyen,Van Hue Trương,Thi Tuyet Ngoc Tran,van Bao Thang Phan,Thi Tuyen Nguyen,Hoang Bach Nguyen,Viet Quynh Tram Ngo,Van Tuan Mai,Paola Molicotti 질병관리본부 2023 Osong Public Health and Research Persptectives Vol.14 No.5
Objectives: Tuberculosis (TB) and drug-resistant TB (DR-TB) are national health burdens in Vietnam. In this study, we investigated the prevalence of rifampicin (RIF) and/or isoniazid (isonicotinic acid hydrazide, INH) resistance in patients with suspected TB, and applied appropriate techniques to help rapidly target DR-TB. Methods: In total, 1,547 clinical specimens were collected and cultured using the BACTEC MGIT system (Becton Dickinson and Co.). A resazurin microtiter assay (REMA) was used to determine the proportions of RIF and/or INH resistance. A real-time polymerase chain reaction panel with TaqMan probes was employed to identify the mutations of rpoB and katG associated with DR-TB in clinical isolates. Genotyping of the identified mutations was also performed. Results: A total of 468 Mycobacterium tuberculosis isolates were identified using the REMA. Of these isolates, 106 (22.6%) were found to be resistant to 1 or both antibiotics. Of the resistant isolates, 74 isolates (69.8%) were resistant to isoniazid (INH) only, while 1 isolate (0.94%) was resistant to RIF only. Notably, 31 isolates (29.24%) were resistant to both antibiotics. Of the 41 phenotypically INH-resistant isolates, 19 (46.3%) had the Ser315Thr mutation. There were 8 different rpoB mutations in 22 (68.8%) of the RIF-resistant isolates. The most frequently detected mutations were at codons 531 (37.5%), 526 (18.8%), and 516 (6.3%). Conclusion: To help prevent new cases of DR-TB in Vietnam, it is crucial to gain a comprehensive understanding of the genotypic DR-TB isolates.
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