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정민영(Minyoung Jung),Jian Kong(Jian Kong ),Hirotaka Kosaka(Hirotaka Kosaka ) 한국특수교육학회 2019 한국특수교육학회 학술대회 Vol.2019 No.-
연구목적: 본 연구의 목적은 자폐스펙트럼장애아동의 생물학특징(Biomarker)을 뇌과학적 접근으로 설명하고 교육현장과 임상현장에서 응용 가능성을 밝히는 것이다. 연구방법: 미국·일본·중국의 7-15세의 Autism Spectrum Disorder (ASD) 남아123명, Attention-Deficit Hyperactivity Disorder (ADHD) 남아124명, ASDA·DHD와의 연령과IQ를 일치시킨 전형발달 남아 189 명을 대상으로 자기 공명 영상 (Magnetic Resonance Imaging : MRI)을 촬영하여 뇌기능·구조분석이 통계처리 되었다. 연구결과: ASD는 동일한 나이와 IQ를 가진 전형발달남아에 비하여 후두엽 (lateral occipital cortex)의 발달에 유의한 차이를 나타내었다. 또한 ASD는 동일한 나이와 IQ를 가진 ADHD에 비교하여 섭엽(insula)의 발달에 유의한 차이를 나타내었다. 결론: 본 연구는 교육현장, 임상현장에서도 활용가능한 생물학적 진단기준과 특징을 명확히 하였으며, ASD와 ADHD에 대한 생물학적 이해를 제공하였다.
Kanji Ueno,Makoto Ishitobi,Hirotaka Kosaka,Kei Ichijo,Yukihiro Nagase 대한정신약물학회 2024 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.22 No.2
Very-late-onset schizophrenia-like psychosis (VLOSLP) is a condition in which psychotic symptoms emerge after the age of 60 years. Given its heterogeneous nature, VLOSLP remains a diagnostic and therapeutic dilemma. Here, we report a case of a 68-year-old patient with psychosis refractory to antipsychotics who was successfully treated with mirtazapine monotherapy. This case suggests that mirtazapine monotherapy may be effective for the treatment of patients with antipsychotic-refractory VLOSLP.
Toru Fujioka,Shinichiro Takiguchi,Chiho Yatsuga,Michio Hiratani,Kang-E M Hong,신민섭,조성준,Hirotaka Kosaka,Akemi Tomoda 대한정신약물학회 2016 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.14 No.1
Objective: This study was conducted to validate the Advanced Test of Attention (ATA) of the visual attention version of Japanese children with attention deficit/hyperactivity disorder (ADHD) and to evaluate the efficacy of methylphenidate (OROS-MPH) and atomoxetine medications. Methods: To assess pharmacotherapy efficacy, the visual version of ATA was administered to 42 children with ADHD. Results were assessed using discriminant analysis, ANOVA for indices of ATA before and after medication treatment, and correlation analysis between the improvement of indices of ATA and clinical symptoms during medication treatment. Results: Discriminant analysis showed that 69.0% of ADHD children were assigned correctly. The T score of commission errors increased as the trial progressed on the medication-off condition. T scores of commission errors and standard deviation of response times on medication-on condition were low compared to the medication-off condition. A few significant correlations were found between the improvements of indices of ATA and ADHD-Rating Scale (RS) during treatment. Conclusion: The performance of the visual version of ATA on medication-off condition reflected the features of ADHD. Furthermore, the medication treatment effects were confirmed sufficiently. In addition, results suggest that indices of ATA reflected aspects of ADHD symptoms that are difficult to elucidate for ADHD-RS. For assessing symptoms and effects of medical treatment in children with ADHD, ATA might be a useful assessment tool.