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Ota, Miho,Ogura, Jun,Ogawa, Shintaro,Kato, Koichi,Matsuda, Hiroshi,Kunugi, Hiroshi 대한핵의학회 2018 핵의학 분자영상 Vol.52 No.3
Purpose Intracranial administration of lipopolysaccharide (LPS) is known to elicit a rapid innate immune response, activate glial cells in the brain, and induce depression-like behavior. However, no study has focused on the changes in glial cells induced by intraperitoneal injection of LPS in vivo. Methods Ten adult male Fischer F344 rats underwent [$^{11}C$]PK11195 PET before and 2 days after intraperitoneal injection of LPS to evaluate the changes in glial cells. The difference in standardized uptake values (SUV) of [$^{11}C$]PK11195 between before and after injection was determined. Results There was a cluster of brain regions that showed significant reductions in SUV. This cluster included the bilateral striata and bilateral frontal regions, especially the somatosensory areas. Conclusions Changes in activity of glial cells induced by the intraperitoneal injection of LPS were detected in vivo by [$^{11}C$]PK11195 PET. Intraperitoneal injection of LPS is known to induce depression, and further studies with [$^{11}C$]PK11195 PET would clarify the relationships between neuroinflammation and depression.
Miho Ota,Junko Matsuo,Noriko Sato,Toshiya Teraishi,Hiroaki Hori,Kotaro Hattori,Yoko Kamio,Norihide Maikusa,Hiroshi Matsuda,Hiroshi Kunugi 대한신경정신의학회 2018 PSYCHIATRY INVESTIGATION Vol.15 No.10
Objective: Autistic spectrum traits are postulated to lie on a continuum that extends between individuals with autism and individuals with typical development. The present study was carried out to investigate functional and network abnormalities associated with autistic spectrum trait in healthy male subjects. Methods: Subjects were 41 healthy male subjects who underwent the social responsiveness scale-adult (SRS-A) and magnetic resonance imaging. Results: There was significant positive correlation between the total score of SRS-A and the regional cerebral blood flow (CBF) in posterior cingulate cortex (PCC). Also, there were changes in functional network such as in cingulate corti, insula and fusiform cortex. Further, we also found the significant difference of functional networks between the healthy male subjects with high or low autistic spectrum trait, and these points were congruent with the previous perceptions derived from autistic-spectrum disorders. Conclusion: These findings suggest a biological basis for the autistic spectrum trait and may be useful for the imaging marker of autism symptomatology.
Miho Ota,Junko Matsuo,Noriko Sato,Toshiya Teraishi,Hiroaki Hori,Kotaro Hattori,Yoko Kamio,Norihide Maikusa,Hiroshi Matsuda,Hiroshi Kunugi 대한신경정신의학회 2018 PSYCHIATRY INVESTIGATION Vol.15 No.11
Objective Autistic spectrum traits are postulated to lie on a continuum that extends between individuals with autism and individuals with typical development. The present study was carried out to investigate functional and network abnormalities associated with autistic spectrum trait in healthy male subjects. Methods Subjects were 41 healthy male subjects who underwent the social responsiveness scale-adult (SRS-A) and magnetic resonance imaging. Results There was significant positive correlation between the total score of SRS-A and the regional cerebral blood flow (CBF) in posterior cingulate cortex (PCC). Also, there were changes in functional network such as in cingulate corti, insula and fusiform cortex. Further, we also found the significant difference of functional networks between the healthy male subjects with high or low autistic spectrum trait, and these points were congruent with the previous perceptions derived from autistic-spectrum disorders. Conclusion These findings suggest a biological basis for the autistic spectrum trait and may be useful for the imaging marker of autism symptomatology.
Design Equation for Punching Shear Capacity of SFRC Slabs
Hiroshi Higashiyama,Akari Ota,Mutsumi Mizukoshi 한국콘크리트학회 2011 International Journal of Concrete Structures and M Vol.5 No.1
In this paper, a design equation for the punching shear capacity of steel fiber reinforced concrete (SFRC) slabs is proposed based on the Japan Society of Civil Engineers (JSCE) standard specifications. Addition of steel fibers into concrete improves mechanical behavior, ductility, and fatigue strength of concrete. Previous studies have demonstrated the effectiveness of fiber reinforcement in improving the shear behavior of reinforced concrete slabs. In this study, twelve SFRC slabs using hooked-ends type steel fibers are tested with varying fiber dosage, slab thickness, steel reinforcement ratio, and compressive strength. Furthermore, test data conducted by earlier researchers are involved to verify the proposed design equation. The proposed design equation addresses the fiber pull-out strength and the critical shear perimeter changed by the fiber factor. Consequently, it is confirmed that the proposed design equation can predict the punching shear capacity of SFRC slabs with an applicable accuracy.
Design Equation for Punching Shear Capacity of SFRC Slabs
Higashiyama, Hiroshi,Ota, Akari,Mizukoshi, Mutsumi Korea Concrete Institute 2011 International Journal of Concrete Structures and M Vol.5 No.1
In this paper, a design equation for the punching shear capacity of steel fiber reinforced concrete (SFRC) slabs is proposed based on the Japan Society of Civil Engineers (JSCE) standard specifications. Addition of steel fibers into concrete improves mechanical behavior, ductility, and fatigue strength of concrete. Previous studies have demonstrated the effectiveness of fiber reinforcement in improving the shear behavior of reinforced concrete slabs. In this study, twelve SFRC slabs using hooked-ends type steel fibers are tested with varying fiber dosage, slab thickness, steel reinforcement ratio, and compressive strength. Furthermore, test data conducted by earlier researchers are involved to verify the proposed design equation. The proposed design equation addresses the fiber pull-out strength and the critical shear perimeter changed by the fiber factor. Consequently, it is confirmed that the proposed design equation can predict the punching shear capacity of SFRC slabs with an applicable accuracy.