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Development of a Transmission Case for Hybrid Vehicles
Hideyuki MAMIYA,Seiji MATSUBARA,Kazuyuki YAMAMOTO,Kyuyeop KWON 한국자동차공학회 2014 한국자동차공학회 부문종합 학술대회 Vol.2014 No.5
This article describes the major issues involved in developing a transmission case (hereafter CASE) for the CVT used on hybrid vehicles (CVT8 HYBRID) and the principal technical measures devised for resolving them. This case was developed jointly with Nissan Motor Co., Ltd. JATCO was responsible for developing and optimizing the case stiffness for supporting the electric motor and Nissan was in charge of developing the motor support structure.
Tanaka, Hideyuki,Matsuoka, Yasutomo,Kawakami, Takuma,Azegami, Yasuhiko,Yamamoto, Masashi,Ohtake, Kazuo,Sone, Takayuki Council on Tall Building and Urban Habitat Korea 2019 International journal of high-rise buildings Vol.8 No.4
We performed calculations combining optimization technologies and Computational Fluid Dynamics (CFD) aimed at reducing wind forces and mitigating wind environments (local strong winds) around buildings. However, the Reynolds Averaged Navier-stokes Simulation (RANS), which seems somewhat inaccurate, needs to be used to create a realistic CFD optimization tool. Therefore, in this study we explored the possibilities of optimizing calculations using RANS. We were able to demonstrate that building configurations advantageous to wind forces could be predicted even with RANS. We also demonstrated that building layouts was more effective than building configurations in mitigating local strong winds around tall buildings. Additionally, we used the Convolutional Neural Network (CNN) as an airflow prediction method alternative to CFD in order to increase the speed of optimization calculations, and validated its prediction accuracy.
Analysis of Risk Factors for Colonic Diverticular Bleeding: A Matched Case-Control Study
( Yuusaku Sugihara ),( Shin Ei Kudo ),( Hideyuki Miyachi ),( Masashi Misawa ),( Shogo Okoshi ),( Hiroyuki Okada ),( Kazuhide Yamamoto ) 대한소화기학회 2016 Gut and Liver Vol.10 No.2
Background/Aims: Diverticular bleeding can occasionally cause massive bleeding that requires urgent colonoscopy (CS) and treatment. The aim of this study was to identify significant risk factors for colonic diverticular hemorrhage. Methods: Between January 2009 and December 2012, 26,602 patients underwent CS at our institution. One hundred twenty-three patients underwent an urgent CS due to acute lower gastrointestinal hemorrhage. Seventy-two patients were diagnosed with colonic diverticular hemorrhage. One hundred forty-nine age- and sex-matched controls were selected from the patients with nonbleeding diverticula who underwent CS during the same period. The relationship of risk factors to diverticular bleeding was compared between the cases and controls. Results: Uni- and multivariate conditional logistic regression analyses demonstrated that the use of nonsteroidal anti-inflammatory drugs (odds ratio [OR], 14.70; 95% confidence interval [CI], 3.89 to 55.80; p<0.0001), as well as the presence of cerebrovascular disease (OR, 8.66; 95% CI, 2.33 to 32.10; p=0.00126), and hyperuricemia (OR, 15.5; 95% CI, 1.74 to 138.00; p=0.014) remained statistically significant predictors of diverticular bleeding. Conclusions: Nonsteroidal anti-inflammatory drugs, cerebrovascular disease and hyperuricemia were significant risks for colonic diverticular hemorrhage. The knowledge obtained from this study may provide some insight into the diagnostic process for patients with lower gastrointestinal bleeding. (Gut Liver 2016;10:244-249)
Tsuyoshi Hattori,Kimio Sugaya,Saori Nishijima,Katsumi Kadekawa,Tomoyuki Ueda,Hideyuki Yamamoto 대한배뇨장애요실금학회 2019 International Neurourology Journal Vol.23 No.2
Purpose: To test the hypothesis that naftopidil prolongs intercontraction intervals in rats undergoing chronic stress as observed in previous animal models, voiding behavior and bladder function were measured and analyzed. Methods: Female Sprague-Dawley rats weighing 200–230 g were exposed to repeated variate stress (RVS) for 1 week, chronic variable mild stress for 2 weeks, or simple mild stress for 1 week. Voiding behavior was assessed in metabolic cages. Voiding frequency and urine output were measured, and changes of these values were compared for the different types of stress. Micturition reflex was analyzed using unconscious cystometry. Naftopidil was administered orally at 30 mg/kg/day for 2 weeks. Results: Unexpectedly, no stress-exposed rats exhibited increased micturition frequency compared to the normal nonstressed control. However, intercontraction intervals were shortened with each type of stress in the unconscious condition, especially by RVS (P<0.01). Naftopidil prolonged the shortened intervals. Conclusions: Although voiding behavior appears approximately normal in rats chronically exposed to emotional stress, internal bladder function can be affected. With anesthesia, micturition intervals were moderately shortened by emotional stress and clearly improved by naftopidil. Therefore, naftopidil appears to act at the spinal level at least.
Tsuyoshi Hattori,Kimio Sugaya,Saori Nishijima,Katsumi Kadekawa,Tomoyuki Ueda,Hideyuki Yamamoto 대한배뇨장애요실금학회 2019 International Neurourology Journal Vol.23 No.4
Purpose: Alpha-1-adrenoceptor blockers (e.g., naftopidil) are prescribed for the treatment of male lower urinary tract symptoms. Although the mechanism of action of naftopidil has been studied in various organs, that in the urinary bladder remains unknown. To clarify the direct effects of naftopidil on this organ, activities were assessed in the isolated rat whole urinary bladder. Methods: A total of 30 female rats were used. In Experiment 1, bladder activity was measured during a cumulative administration of 2.5–75μM naftopidil (n=7). In Experiment 2, rats were divided into 2 groups: control (n=10) and naftopidil (5 mg/ animal/day, oral gavage, once-daily for 2 weeks) (n=13). After the treatment period, plasma was obtained from each rat. The urinary bladders were harvested from the control rats. Isovolumetric rhythmic bladder contractions were induced at above the threshold volume, and intravesical pressure was recorded. Control plasma was added to the organ bath; after subsequent wash-out, plasma collected from rats administered naftopidil was added. In Experiment 3, the plasma levels of monoamines and amino acids were quantified using the individual plasma prepared in the Experiment 2. Results: Cumulative dosing with naftopidil did not change the interval between spontaneous contractions compared to the interval at baseline. After adding control plasma, the interval was shortened compared to the baseline (P=0.008). The plasma collected from rats administered naftopidil suppressed the shortening of the interval compared to the control plasma (P=0.041). Naftopidil resulted in a decrease in the level of noradrenaline (P=0.009) and an increase in that of glycine (P=0.014). Conclusions: Although naftopidil did not directly act on the interval between spontaneous contractions of the urinary bladder, the plasma collected from rats administered naftopidil, with changing levels of monoamines and amino acids, may suppressed shortening the interval.
Takashi Tamura,Yasunobu Yamashita,Kazuki Ueda,Yuki Kawaji,Masahiro Itonaga,Shin-ichi Murata,Kaori Yamamoto,Takeichi Yoshida,Hiroki Maeda,Takao Maekita,Mikitaka Iguchi,Hideyuki Tamai,Masao Ichinose,Jun 대한소화기내시경학회 2017 Clinical Endoscopy Vol.50 No.4
Background/Aims: Endoscopic ultrasonography-guided fine-needle aspiration (EUS-FNA) has been used to diagnose gastrointestinal submucosal tumors (SMTs). Although rapid on-site evaluation (ROSE) has been reported to improve the diagnostic accuracy of EUS-FNA for pancreatic lesions, on-site cytopathologists are not routinely available. Given this background, the usefulness of ROSE by endosonographers themselves for pancreatic tumors has also been reported. However, ROSE by endosonographers for diagnosis of SMT has not been reported. The aim of this study was to evaluate the diagnostic accuracy of EUS-FNA with ROSE by endosonographers for SMT, focusing on diagnosis of gastrointestinal stromal tumor (GIST), compared with that of EUS-FNA alone. Methods: Twenty-two consecutive patients who underwent EUS-FNA with ROSE by endosonographers for SMT followed by surgical resection were identified. Ten historical control subjects who underwent EUS-FNA without ROSE were used for comparison. Results: The overall diagnostic accuracy for SMT was significantly higher in cases with than without ROSE (100% vs. 80%, p=0.03). The number of needle passes by FNA with ROSE by endosonographers tended to be fewer, although accuracy was increased (3.3±1.3 vs. 5.9±3.8, p=0.06). Conclusions: ROSE by endosonographers during EUS-FNA for SMT is useful for definitive diagnosis, particularly for GIST.