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Cho, Sang-Geon,Park, Ki Seong,Kang, Sae-Ryung,Kim, Jahae,Jun, Haeng Man,Cho, Jae Yeong,Jeong, Hae Chang,Kim, Ju Han,Jeong, Geum-Cheol,Park, Hee Jeong,Kwon, Seong Young,Min, Jung-Joon,Bom, Henry Hee-Se The Korea Society of Nuclear Medicine 2016 핵의학 분자영상 Vol.50 No.1
Purpose To evaluate the perfusion decrease in donor myocardium by collateral circulation and its correlation with angina pectoris in patients with chronic total occlusion (CTO) using myocardial perfusion single-photon emission computed tomography (MPS). Materials and Methods Thirty-six patients with single-vessel CTO without any other stenosis were included. All patients underwent MPS and coronary angiography (CAG) within 2 months. Total 72 donor arteries were evaluated for the grades of collaterals to the CTO artery using the Rentrop grading system on CAG. Perfusion defects and perfusion scores in donor and CTO territories were analyzed on MPS. Myocardial perfusion of donor and CTO territories were evaluated according to the presence of angina pectoris and the grades of collateral circulation. Results When the CTO territory was ischemic, symptomatic patients showed higher summed difference scores in the CTO territory compared to asymptomatic patients ($3.5{\pm}2.4$ vs. $1.5{\pm}0.8$ for symptomatic and asymptomatic groups respectively; p = 0.034). However, when the CTO territory was nonischemic, symptomatic patients showed higher summed stress scores (SSS, $4.3{\pm}2.9$ vs. $1.6{\pm}1.2$; p=0.032) and summed rest scores (SRS, $4.2{\pm}2.5$ vs. $1.5{\pm}1$.1; p=0.003) in the donor territories. On the per-vessel analysis, perfusion defects in donor territories were more frequent (0 % vs. 53 % vs. 86 % for Rentrop 0, Rentrop 1-2 and Rentrop 3, respectively; p<0.001) and showed higher SSS ($0.0{\pm}0.0$, $1.3{\pm}1.6$ and $2.1{\pm}1.1$ for Rentrop 0, Rentrop 1-2 and Rentrop 3, respectively; p=0.001) and SRS ($0.0{\pm}0.0$, $1.0{\pm}1.4$ and $1.7{\pm}1.2$; p=0.003) at higher Rentrop grades, but their patterns were variable. Conclusion Angina pectoris was related to either ischemia of the myocardium beyond CTO or a perfusion decrease in the donor myocardium. The perfusion decrease in donor myocardium positively correlated with the collateral grades.
Antimelanogenic effect of Pini Nodi Lignum extract in HM3KO melanoma cells
Hee-Ryung Cho,강경아,Mohammad Iqbal Hossain Bhuiyan,Myung-Sook Oh,이무형,김연정 대한독성 유전단백체 학회 2011 Molecular & cellular toxicology Vol.7 No.2
The control of melanogenesis is an important strategy in the treatment of abnormal skin pigmentation for cosmetic purpose. In mammals, melanin synthesis is regulated by melanogenic enzymes, such as tyrosinase, tyrosinase related protein (TRP)-1 and TRP -2. Our aim was to study whether Pini Nodi Lignum (PNL), an extract of Pinus tabulaeformis nodes, possesses antimelanogenic activity. To examine the inhibitory effect of PNL on melanogenesis, tyrosinase inhibition assay, melanin content assay, RT-PCR analysis and Western blotting of tyrosinase, TRP-1, and TRP-2 were performed using HM3KO melanoma cells. The results showed that treatment of HM3KO cells with PNL inhibited melanin formation without affecting normal cell growth. Cell-free tyrosinase inhibition assay exhibited that PNL directly inhibited mushroom tyrosinase enzyme catalytic activity. Moreover, it was found that application of PNL significantly suppressed tyrosinase and TRP-1 mRNA and protein expression, but not that of TRP-2, in HM3KO cells. These results suggest that the inhibitory effect of PNL on melanogenesis is not only by inhibiting tyrosinase catalytic activity but also by inhibiting expression of melanogenic proteins at the transcriptional and translational levels. The PNL can be exploited as the effective whitening agent that possesses antimelanogenic activity.