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Concepts for solution-processable OLED materials at Merck
Hayer, A.,Anemian, R.,Eberle, T.,Heun, S.,Ludemann, A.,Schulte, N.,Buchholz, H. The Korean Infomation Display Society 2011 Journal of information display Vol.12 No.1
Drastic performance increase and accelerated progress in organic light-emitting diodes from solutions are shown using solution-processable small molecules based on the core structures of vacuum-evaporable materials. Systematic modification of small-molecule materials toward better processability from solutions at identical electro-optical properties is shown. This is demonstrated to lead to a significant improvement in the device performance.
Concepts for solution-processable OLED materials at Merck
A. Hayer,R. Anémian,T. Eberle,S. Heun,A. Ludemann,N. Schulte,H. Buchholz 한국정보디스플레이학회 2011 Journal of information display Vol.12 No.1
Drastic performance increase and accelerated progress in organic light-emitting diodes from solutions are shown using solution-processable small molecules based on the core structures of vacuum-evaporable materials. Systematic modification of small-molecule materials toward better processability from solutions at identical electro-optical properties is shown. This is demonstrated to lead to a significant improvement in the device performance.
Hossein Hayer,Omid Bakhtiari,Toraj Mohammadi 한국공업화학회 2015 Journal of Industrial and Engineering Chemistry Vol.21 No.1
Membrane distillation is one of the newest methods for water purification. In this study, the behavior ofdirect contact membrane distillation (DCMD) process under various operating conditions wasmathematically modeled using computational fluid dynamics (CFD) method. The effects of differentparameters on transmembrane flux and temperature polarization coefficient (TPC) were measured byglobal sensitivity analysis technique. The sensitivity analysis results indicated that the most affectingdesign parameters in DCMD are membrane thickness and feed temperature.
IRF1 is critical for the TNF-driven interferon response in rheumatoid fibroblast-like synoviocytes
Michael Bonelli,Karolina Dalwigk,Alexander Platzer,Isabel Olmos Calvo,Silvia Hayer,Birgit Niederreiter,Johannes Holinka,Florian Sevelda,Thomas Pap,Günter Steiner,Giulio Superti-Furga,Josef S. Smolen,H 생화학분자생물학회 2019 Experimental and molecular medicine Vol.51 No.-
Rheumatoid arthritis (RA) is an autoimmune disease characterized by persistent synovial inflammation. The major drivers of synovial inflammation are cytokines and chemokines. Among these molecules, TNF activates fibroblast-like synoviocytes (FLSs), which leads to the production of inflammatory mediators. Here, we show that TNF regulates the expression of the transcription factor interferon regulatory factor 1 (IRF1) in human FLSs as well as in a TNF transgenic arthritis mouse model. Transcriptomic analyses of IRF1-deficient, TNF-stimulated FLSs define the interferon (IFN) pathway as a major target of IRF1. IRF1 expression is associated with the expression of IFNβ, which leads to the activation of the JAK-STAT pathway. Blocking the JAK-STAT pathway with the Janus kinase inhibitor (JAKinib) baricitinib or tofacitinib reduces the expression of IFN-regulated genes (IRGs) in TNF-activated FLSs. Therefore, we conclude that TNF induces a distinct inflammatory cascade, in which IRGs are key elements, in FLSs. The IFN-signature might be a promising biomarker for the efficient and personalized use of new treatment strategies for RA, such as JAKinibs.