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Medhat M. Hassan,E.S. Fathy,Raouf O. Aly,S.E. Abdel Aal,Ahmed M. El-Masry 한국공업화학회 2013 Journal of Industrial and Engineering Chemistry Vol.19 No.5
Waste rubber (WR) powder was introduced in a two-roll mill in the presence of various ratios of curatives to develop sheets of devulcanized waste rubber (DWR). The product has been investigated by FTIR, TGA and SEM. A thermoplastic elastomer (TPE) was prepared by blending the obtained DWR with high density polyethylene (HDPE) at different feed ratios under conditions of gamma irradiation, 25, 50, 100, and 150 kGy. The mechanical parameters of the blend: tensile strength, elongation at break, and hardness (Shore D) were studied. In addition, blend characterization using FTIR spectra, gel fraction, TGA and SEM was discussed.
Medhat M. Hassan,E.S. Fathy,Raouf O. Aly,S.E. Abdel Aal,Ahmed M. El-Masry 한국공업화학회 2013 Journal of Industrial and Engineering Chemistry Vol.19 No.5
Waste rubber (WR) powder was introduced in a two-roll mill in the presence of various ratios of curatives to develop sheets of devulcanized waste rubber (DWR). The selected product was investigated by FTIR, TGA and SEM. In a roll mill and hot press, styrene butadiene rubber (SBR) gum was differentially replaced by DWR feed ratios, and thereafter irradiated with gamma rays. The mechanical parameters of the developed blend were examined. Oil resistance and thermogravemetric behavior were discussed. Remarked improvement in the mechanical, thermal and physical parameters of SBR was generally determined by the incorporation of DWR and gamma irradiation.
Potential Benefit of Metformin as Treatment for Colon Cancer: the Evidence so Far
Abdelsatir, Azza Ali,Husain, Nazik Elmalaika,Hassan, Abdallah Tarig,Elmadhoun, Wadie M,Almobarak, Ahmed O,Ahmed, Mohamed H Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.18
Metformin is known as a hypoglycaemic agent that regulates glucose homeostasis by inhibiting liver glucose production and increasing muscle glucose uptake. Colorectal cancer (CRC) is one of the most common cancers worldwide, with about a million new cases diagnosed each year. The risk factors for CRC include advanced age, smoking, black race, obesity, low fibre diet, insulin resistance, and the metabolic syndrome. We have searched Medline for the metabolic syndrome and its relation to CRC, and metformin as a potential treatment of colorectal cancer. Administration of metformin alone or in combination with chemotherapy has been shown to suppress CRC. The mechanism that explains how insulin resistance is associated with CRC is complex and not fully understood. In this review we have summarised studies which showed an association with the metabolic syndrome as well as studies which tackled metformin as a potential treatment of CRC. In addition, we have also provided a summary of how metformin at the cellular level can induce changes that suppress the activity of cancer cells.
Hafez, Mohamed M.,Al-Shabanah, Othman A.,Al-Rejaie, Salim S.,Al-Harbi, Naif O.,Hassan, Zeinab K.,Alsheikh, Abdulmalik,Theyab, Abdurrahman I. Al,Aldelemy, Meshan L.,Sayed-Ahmed, Mohamed M. Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.2
Triple negative breast cancer (TNBC) is an aggressive subtype of breast cancer (BC) with higher metastatic rate and both local and systemic recurrence compared to non-TNBC. The generation of reactive oxygen species (ROS) secondary to oxidative stress is associated with DNA damage, chromosomal degradation and alterations of both hypermethylation and hypomethylation of DNA. This study concerns differential methylation of promoter regions in specific groups of genes in TNBC and non-TNBC Saudi females in an effort to understand whether epigenetic events might be involved in breast carcinogenesis, and whether they might be used as markers for Saudi BCs. Methylation of glutathione S-transferase P1 (GSTP1), T-cadherin (CDH13), Paired box protein 5 (PAX5), death associated protein kinase (DAPK), twist-related protein (TWIST), DNA-binding protein inhibitor (ID4), High In Normal-1 (HIN-1), cyclin-dependent kinase inhibitor 2A (p16), cyclin D2 and retinoic acid receptor-${\beta}$ ($RAR{\beta}1$) genes was analyzed by methylation specific polymerase chain reaction (MSP) in 200 archival formalin-fixed paraffin embedded BC tissues divided into 3 groups; benign breast tissues (20), TNBC (80) and non-TNBC (100). The relationships between methylation status, and clinical and pathological characteristics of patients and tumors were assessed. Higher frequencies of GSTP1, ID4, TWIST, DAPK, PAX5 and HIN-1 hypermethylation were found in TNBC than in non-TNBC. Hypermethylation of GSTP1, CDH13, ID4, DAPK, HIN-1 and PAX5 increased with tumor grade increasing. Other statistically significant correlations were identified with studied genes. Data from this study suggest that increased hypermethylation of GSTP1, ID4, TWIST, DAPK, PAX5 and HIN-1 genes in TNBC than in non-TNBC can act as useful biomarker for BCs in the Saudi population. The higher frequency of specific hypermethylated genes paralleling tumor grade, size and lymph node involvement suggests contributions to breast cancer initiation and progression.
Abdel‐Baki Abdel‐Azeem S.,Aboelhadid Shawky M.,Sokmen Atalay,Al‐Quraishy Saleh,Hassan Ahmed O.,Kamel Asmaa A. 한국곤충학회 2021 Entomological Research Vol.51 No.11
The present study was designed to evaluate the insecticidal activity of different concentrations of Foeniculum vulgare and two of its components, trans-anethole and fenchone, against the different stages of Musca domestica. The tested concentrations were applied through a residual film method and topical application on larvae and pupae respectively. Trans-anethole achieved the best results against larvae when compared with those of the fennel or fenchone with LC50 values of 0.58%, 1.57%, and 17.22%, respectively. Moreover, tans-anethole killed 100% of larvae at concentration of 2.5% and fennel achieved the same effect at concentration of 10%, meanwhile fenchone did not reach such an effect at any of the tested concentrations. At the concentration of 10%, fennel oil and trans-anethole induced morphological deformation in the dead larvae such as shrunk bodies with dark colored integument. Regarding the pupicidal activity, fennel oil showed percentage inhibition rate (PIR) of 100% at the concentration of 10% while the same effect was achieved by trans-anethole at concentration of 5%. On the contrary, fenchone did not show any pupicidal activity. Treatment of the third instar house fly larvae with LC5o of fennel oil, trans-anethole, and fenchone significantly inhibited the acetylcholinestrase (AchE) when compared with the control untreated larvae. Additionally, the glutathione-s-transferase (GST) and malondialdehyde (MDA) production significantly increased in the larvae treated with trans-anethole. The results of the present study indicate that the insecticidal activity of fennel oil was mainly attributed to the presence of trans-anethole as a major constituent.