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- 저자 : Theyab, Abdurrahman I. Al (검색결과 2 건)
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Nader A. Al Theeb,Mohammed S. Obeidat,Manar Aljarrah,Theyab A. Alhwiti 대한산업공학회 2019 Industrial Engineeering & Management Systems Vol.18 No.4
A single machine scheduling problem with sequence-dependent setup times and setup costs has a critical role in manufacturing and service sectors to minimize orders delays and costs. This study provides multiple objectives model tosolve the single machine total weighted tardiness and setup costs scheduling problem associated with sequencedependent setup times and sequence-dependent setup costs (MOSTWTSCSD). The objectives are to minimize thetotal weighted tardiness and the total setup costs for all jobs without any certain relationship between the setup timeand the setup cost, as happened in some machines. An alternative heuristic procedure based on discrete particle swarmoptimization (DPSO) is suggested to find representative Pareto front (non-dominated) solutions. Many efficient methods have been used inside the DPSO to improve its performance. Results show that the ability of the suggested solution approach to provide a representative Pareto fronts in reasonable computational efforts compared with anotherheuristic.
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Hafez, Mohamed M.,Al-Shabanah, Othman A.,Al-Rejaie, Salim S.,Al-Harbi, Naif O.,Hassan, Zeinab K.,Alsheikh, Abdulmalik,Theyab, Abdurrahman I. Al,Aldelemy, Meshan L.,Sayed-Ahmed, Mohamed M. Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.2
Triple negative breast cancer (TNBC) is an aggressive subtype of breast cancer (BC) with higher metastatic rate and both local and systemic recurrence compared to non-TNBC. The generation of reactive oxygen species (ROS) secondary to oxidative stress is associated with DNA damage, chromosomal degradation and alterations of both hypermethylation and hypomethylation of DNA. This study concerns differential methylation of promoter regions in specific groups of genes in TNBC and non-TNBC Saudi females in an effort to understand whether epigenetic events might be involved in breast carcinogenesis, and whether they might be used as markers for Saudi BCs. Methylation of glutathione S-transferase P1 (GSTP1), T-cadherin (CDH13), Paired box protein 5 (PAX5), death associated protein kinase (DAPK), twist-related protein (TWIST), DNA-binding protein inhibitor (ID4), High In Normal-1 (HIN-1), cyclin-dependent kinase inhibitor 2A (p16), cyclin D2 and retinoic acid receptor-${\beta}$ ($RAR{\beta}1$) genes was analyzed by methylation specific polymerase chain reaction (MSP) in 200 archival formalin-fixed paraffin embedded BC tissues divided into 3 groups; benign breast tissues (20), TNBC (80) and non-TNBC (100). The relationships between methylation status, and clinical and pathological characteristics of patients and tumors were assessed. Higher frequencies of GSTP1, ID4, TWIST, DAPK, PAX5 and HIN-1 hypermethylation were found in TNBC than in non-TNBC. Hypermethylation of GSTP1, CDH13, ID4, DAPK, HIN-1 and PAX5 increased with tumor grade increasing. Other statistically significant correlations were identified with studied genes. Data from this study suggest that increased hypermethylation of GSTP1, ID4, TWIST, DAPK, PAX5 and HIN-1 genes in TNBC than in non-TNBC can act as useful biomarker for BCs in the Saudi population. The higher frequency of specific hypermethylated genes paralleling tumor grade, size and lymph node involvement suggests contributions to breast cancer initiation and progression.
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