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      • Identification of Genetic and Non-genetic Risk Factors for Nasopharyngeal Carcinoma in a Southeast Asian Population

        Hashim, Nikman Adli Nor,Ramzi, Nurul Hanis,Velapasamy, Sharmila,Alex, Livy,Chahil, Jagdish Kaur,Lye, Say Hean,Munretnam, Khamsigan,Haron, Mohd Roslan,Ler, Lian Wee Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.12

        Background: Nasopharyngeal carcinoma (NPC) is endemic in Southern Chinese and Southeast Asian populations. Geographical and ethnic clustering of the cancer is due to genetic, environmental, and lifestyle risk factors. This case-control study aimed to identify or confirm both genetic and non-genetic risk factors for NPC in one of the endemic countries, Malaysia. Materials and Methods: A panel of 768 single-nucleotide polymorphisms (SNPs) previously associated with various cancers and known non-genetic risk factors for NPC were selected and analyzed for their associations with NPC in a case-control study. Results: Statistical analysis identified 40 SNPs associated with NPC risk in our population, including 5 documented previously by genome-wide association studies (GWAS) and other case-control studies; the associations of the remaining 35 SNPs with NPC were novel. In addition, consistent with previous studies, exposure to occupational hazards, overconsumption of salt-cured foods, red meat, as well as low intake of fruits and vegetables were also associated with NPC risk. Conclusions: In short, this study confirmed and/or identified genetic, environmental and dietary risk factors associated with NPC susceptibility in a Southeast Asian population.

      • A five-variable refined plate theory for thermal buckling analysis of composite plates

        Hashim, Hussein A.,Sadiq, Ibtehal Abbas Techno-Press 2021 Composite materials and engineering Vol.3 No.2

        This research is devoted to investigate the thermal buckling analysis behaviour of laminated composite plates, by applying an analytical model based on a refined plate theory (RPT) with five independent unknown variables. The theory accounts for parabolic distribution of the transvers shear strains through the plate thickness, and satisfied the zero traction boundary condition on the surface without using shear correction factors, hence a shear correction factor is not required. The governing differential equations and associated boundary conditions are derived by employing the principle of virtual work and solved via Navier-type analytical procedure to obtain critical buckling temperature for simply supported boundary condition of symmetric and antisymmetric cross-ply and angle-ply laminated plates. MATLAB 2018 program is used to investigate the effect of thickness ratio (a/h), aspect ratio (a/b), orthogonality ratio (E<sub>1</sub>/E<sub>2</sub>), coefficient of thermal expansion ratio (α<sub>2</sub>/α<sub>1</sub>) and numbers of layers on thermal buckling of laminated plate. It can be concluded that this theory gives good results when compared with other theory.

      • KCI등재

        Development of Flavouring Ontology for Recommending the Halal Status of Flavours

        Hashim Siti Farhana Mohamad,Noah Shahrul Azman Mohd,Salim Juhana,Mustapha Wan Aida Wan 한국과학기술정보연구원 2024 Journal of Information Science Theory and Practice Vol.12 No.2

        There has been a growing interest in halal-related ontology research in recent years, as ontology has gained recognition in the halal industry. This paper discusses the development of a flavouring ontology that will assist halal management auditors in predicting the halal status of flavours in order to process food producers’ applications for halal certification. The development of a flavouring ontology is based on multiple references, because the auditors of halal management divisions must consult a variety of sources independently in order to determine the halal status of flavourings. The process includes 1) determining the ontology goal and scope, 2) building ontologies, and 3) evaluating the ontologies. The researcher used Protégé to design the ontologies, and Phyton was used to develop a prototype based on flavouring ontology. The developed ontology consists of four classes, nine sub-classes, and 11 relationships. The evaluation of the ontology using the prototype revealed that the majority of experts were satisfied with the information generated by the ontology in the prototype, particularly in relation to synonyms and the hierarchical structure of a flavour. However, the experts suggest improvements in terms of flavour metadata, especially on raw materials and natural occurrence data, so that the flavour information retrieved is comprehensive and accurate.

      • SSCISCOPUSKCI등재

        Career, Family and Community

        Hashim, Habsah,Omar, Roziah 숙명여자대학교 아시아여성연구소 2004 Asian Women Vol.19 No.-

        This paper aims to analyze the dilemma faced by professional and semi-professional Malay women in terms of various roles, namely the reproductive role (family), the productive role (career), and the community-organizing role. The reproductive role, which is seen as the typical women's job, is analyzed in terms of fertility, childcare and domestic duties. The productive role, which is highly related to education level, is looked at in terms of perception and choices and also career development. The community organizing role, an often neglected aspect, is measured by involvement in local community organizations and associations. The study found that children are regarded as blessings in the Malay households and did not hinder the mothers to participate in labor force. However, being dual-earner households, work-family conflicts, childcare arrangements and domestic chores do create tensions and dilemmas. The women, though most are educated, seem to make sacrifices and forego their own personal attainment in order to cope with the dual-role. Participation in community work in general, is always the least priority. From the study, it is found that more family-friendly policies are urgently needed.

      • CT Based 3-Dimensional Treatment Planning of Intracavitary Brachytherapy for Cancer of the Cervix : Comparison between Dose-Volume Histograms and ICRU Point Doses to the Rectum and Bladder

        Hashim, Natasha,Jamalludin, Zulaikha,Ung, Ngie Min,Ho, Gwo Fuang,Malik, Rozita Abdul,Ee Phua, Vincent Chee Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.13

        Background: CT based brachytherapy allows 3-dimensional (3D) assessment of organs at risk (OAR) doses with dose volume histograms (DVHs). The purpose of this study was to compare computed tomography (CT) based volumetric calculations and International Commission on Radiation Units and Measurements (ICRU) reference-point estimates of radiation doses to the bladder and rectum in patients with carcinoma of the cervix treated with high-dose-rate (HDR) intracavitary brachytherapy (ICBT). Materials and Methods: Between March 2011 and May 2012, 20 patients were treated with 55 fractions of brachytherapy using tandem and ovoids and underwent post-implant CT scans. The external beam radiotherapy (EBRT) dose was 48.6Gy in 27 fractions. HDR brachytherapy was delivered to a dose of 21 Gy in three fractions. The ICRU bladder and rectum point doses along with 4 additional rectal points were recorded. The maximum dose ($D_{Max}$) to rectum was the highest recorded dose at one of these five points. Using the HDRplus 2.6 brachyhtherapy treatment planning system, the bladder and rectum were retrospectively contoured on the 55 CT datasets. The DVHs for rectum and bladder were calculated and the minimum doses to the highest irradiated 2cc area of rectum and bladder were recorded ($D_{2cc}$) for all individual fractions. The mean $D_{2cc}$ of rectum was compared to the means of ICRU rectal point and rectal $D_{Max}$ using the Student's t-test. The mean $D_{2cc}$ of bladder was compared with the mean ICRU bladder point using the same statistical test. The total dose, combining EBRT and HDR brachytherapy, were biologically normalized to the conventional 2 Gy/fraction using the linear-quadratic model. (${\alpha}/{\beta}$ value of 10 Gy for target, 3 Gy for organs at risk). Results: The total prescribed dose was $77.5Gy{\alpha}/{\beta}10$. The mean dose to the rectum was $4.58{\pm}1.22Gy$ for $D_{2cc}$, $3.76{\pm}0.65Gy$ at $D_{ICRU}$ and $4.75{\pm}1.01Gy$ at $D_{Max}$. The mean rectal $D_{2cc}$ dose differed significantly from the mean dose calculated at the ICRU reference point (p<0.005); the mean difference was 0.82 Gy (0.48-1.19Gy). The mean EQD2 was $68.52{\pm}7.24Gy_{{\alpha}/{\beta}3}$ for $D_{2cc}$, $61.71{\pm}2.77Gy_{{\alpha}/{\beta}3}$ at $D_{ICRU}$ and $69.24{\pm}6.02Gy_{{\alpha}/{\beta}3}$ at $D_{Max}$. The mean ratio of $D_{2cc}$ rectum to $D_{ICRU}$ rectum was 1.25 and the mean ratio of $D_{2cc}$ rectum to $D_{Max}$ rectum was 0.98 for all individual fractions. The mean dose to the bladder was $6.00{\pm}1.90Gy$ for $D_{2cc}$ and $5.10{\pm}2.03Gy$ at $D_{ICRU}$. However, the mean $D_{2cc}$ dose did not differ significantly from the mean dose calculated at the ICRU reference point (p=0.307); the mean difference was 0.90 Gy (0.49-1.25Gy). The mean EQD2 was $81.85{\pm}13.03Gy_{{\alpha}/{\beta}3}$ for $D_{2cc}$ and $74.11{\pm}19.39Gy_{{\alpha}/{\beta}3}$ at $D_{ICRU}$. The mean ratio of $D_{2cc}$ bladder to $D_{ICRU}$ bladder was 1.24. In the majority of applications, the maximum dose point was not the ICRU point. On average, the rectum received 77% and bladder received 92% of the prescribed dose. Conclusions: OARs doses assessed by DVH criteria were higher than ICRU point doses. Our data suggest that the estimated dose to the ICRU bladder point may be a reasonable surrogate for the $D_{2cc}$ and rectal $D_{Max}$ for $D_{2cc}$. However, the dose to the ICRU rectal point does not appear to be a reasonable surrogate for the $D_{2cc}$.

      • SCISCIESCOPUS
      • A new approach for solving global optimization and engineering problems based on modified sea horse optimizer

        Hashim Fatma A,Mostafa Reham R,Khurma Ruba Abu,Qaddoura Raneem,Castillo Pedro A 한국CDE학회 2024 Journal of computational design and engineering Vol.11 No.1

        Sea horse optimizer (SHO) is a noteworthy metaheuristic algorithm that emulates various intelligent behaviors exhibited by sea horses, encompassing feeding patterns, male reproductive strategies, and intricate movement patterns. To mimic the nuanced locomotion of sea horses, SHO integrates the logarithmic helical equation and Levy flight, effectively incorporating both random movements with substantial step sizes and refined local exploitation. Additionally, the utilization of Brownian motion facilitates a more comprehensive exploration of the search space. This study introduces a robust and high-performance variant of the SHO algorithm named modified sea horse optimizer (mSHO). The enhancement primarily focuses on bolstering SHO’s exploitation capabilities by replacing its original method with an innovative local search strategy encompassing three distinct steps: a neighborhood-based local search, a global non-neighbor-based search, and a method involving circumnavigation of the existing search region. These techniques improve mSHO algorithm’s search capabilities, allowing it to navigate the search space and converge toward optimal solutions efficiently. To evaluate the efficacy of the mSHO algorithm, comprehensive assessments are conducted across both the CEC2020 benchmark functions and nine distinct engineering problems. A meticulous comparison is drawn against nine metaheuristic algorithms to validate the achieved outcomes. Statistical tests, including Wilcoxon’s rank-sum and Friedman’s tests, are aptly applied to discern noteworthy differences among the compared algorithms. Empirical findings consistently underscore the exceptional performance of mSHO across diverse benchmark functions, reinforcing its prowess in solving complex optimization problems. Furthermore, the robustness of mSHO endures even as the dimensions of optimization challenges expand, signifying its unwavering efficacy in navigating complex search spaces. The comprehensive results distinctly establish the supremacy and efficiency of the mSHO method as an exemplary tool for tackling an array of optimization quandaries. The results show that the proposed mSHO algorithm has a total rank of 1 for CEC2020 test functions. In contrast, the mSHO achieved the best value for the engineering problems, recording a value of 0.012 665, 2993.634, 0.01 266, 1.724 967, 263.8915, 0.032 255, 58 507.14, 1.339 956, and 0.23 524 for the pressure vessel design, speed reducer design, tension/compression spring, welded beam design, three-bar truss engineering design, industrial refrigeration system, multi-product batch plant, cantilever beam problem, and multiple disc clutch brake problems, respectively. Source codes of mSHO are publicly available at https://www.mathworks.com/matlabcentral/fileexchange/135882-improved-sea-horse-algorithm.

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