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(Haryoung Poo),(Young Ik Lee),(Robert F. Todd III),(Howard R . Petty) 생화학분자생물학회 1998 BMB Reports Vol.31 No.1
Recent studies have suggested that integrin (CR3) participates in the signal transduction pathways of certain GPI-anchored phagocytic receptors including FcγRIIIB. One consequence of this functional linkage is an inducible association between CR3 and cortical microfilaments that is triggered by FcγRIIIB binding to immobilized immune complexes (IC). That this signaling event requires the co-expression of FcγRIIIB with CR3 was documented by the use of NIH 3T3 transfectants expressing both CR3 and FcγRIIIB (clone 3-23), CR3 alone (clone 3-19), and FcγRIIIB alone (clone 3-15). Pretreatment of 3-23 cells with protein kinase inhibitors such as staurosporine and methyl 2,5-dihydroxycinnamate (MDHC) blocked IC-stimulated CR3-microfilament proximity without affecting the extent to which FcγRIIIB constrains the lateral membrane mobility of a subset of CR3 on the cell surface (as measured in fluorescence recovery after photobleaching experiments). These data support that CR3 and FcγRIIIB molecules are physically and functionally associated and that ligation of FcgRIIIB triggers CR3-dependent signal transduction.
Poo, Haryoung,Lee, Young-Ik,Todd III, Robert F.,Petty, Howard R. The Korea Science and Technology Center 1998 BMB Reports Vol.31 No.1
Recent studies have suggested that integrin (CR3) participates in the signal transduction pathways of certain GPI-anchored phagocytic receptors including FcγRⅢB. One consequence of this functional linkage is an inducible association between CR3 and cortical microfilaments that is triggered by FcγRⅢB binding to immobilized immune complexes (IC). That this signaling event requires the c0-expression of FcγRⅢB with CR3 was documented by the use of NIH 3T3 transfectants expressing both CR3 and FcγRⅢB (clone 3-23), CR3 alone (clone 3-19), and FcγRⅢB alone (clone 3-15). Pretreatment of 3-23 cells with protein kinase inhibitors such as staurosporine and methyl 2,5-dihydroxycinnamate (MDHC) blocked IC-stimulated CR3-microfilament proximity without affecting the extent to which FcγRⅢB constrains the lateral membrane mobility of subset of CR3 on the cell surface (as measured in fluorescence recovery after photobleaching experiments). These data support that CR3 and FcγRⅢB molecules are physically and functionally associated and that ligation of FcgRⅢB triggers CR3-dependent signal transduction.
New Biological Functions and Applications of High-Molecular-Mass Poly-γ-glutamic Acid
Poo, Haryoung,Park, Chung,Kwak, Mi-Sun,Choi, Doo-Yeol,Hong, Seung-Pyo,Lee, Il-Han,Lim, Yong Taik,Choi, Young Ki,Bae, Sun-Ryang,Uyama, Hiroshi,Kim, Chul-Joong,Sung, Moon-Hee WILEY-VCH Verlag 2010 CHEMISTRY AND BIODIVERSITY Vol.7 No.6
<P>Ultra-high-molecular-weight poly-γ-glutamic acid (γ-PGA) is a most promising biodegradable polymer that is produced by Bacillus subtilis (chungkookjang). Attractive properties of γ-PGA are that it is water soluble, anionic, biodegradable, and edible. Development of γ-PGA has pursued in terms of cosmetics/skin care, bone care, nanoparticle for drug delivery system, hydrogel, and so on. Very recently, our research has shown that γ-PGA can be used as an immune-stimulating agent, especially at high molecular weight. This review presents the synthesis and production of high-molecular-weight γ-PGA and its various applications in industrial fields.</P>
Photobacterium atrarenae sp. nov. a Novel Bacterium Isolated from Sea Sand
Kim, Byung-Chun,Poo, Haryoung,Kim, Mi Na,Lee, Kang Hyun,Lee, Jongtae,Rhee, Moon-Soo,Shin, Kee-Sun Springer-Verlag 2011 Current microbiology Vol.63 No.5
<P>The gram-reaction-negative, motile, facultatively anaerobic, catalase-positive, oxidase-positive bacterial strain M3-4(T) was isolated from black sea sand and subjected to a taxonomic study. Cells of strain M3-4(T) have monotrichous flagella, grow optimally at 37°C and at pH 7-8 in the presence of 1-4% (w/v) NaCl and hydrolyze casein, starch and L: -tyrosine. According to phylogenetic analyses using 16S rRNA gene sequences, strain M3-4(T) belongs to the genus Photobacterium and is most closely related to Photobacterium rosenbergii LMG 22223(T) (97.4%) and P. gaetbulicola KCTC 22804(T) (96.6%). The DNA-DNA relatedness value between M3-4(T) and P. rosenbergii LMG 22223(T) was 21.5%. The DNA G+C mol% of strain M3-4(T) was 53.6. The major cellular fatty acid of strain M3-4(T) was a summed feature 3 consisting of C(16:1) ??7c and/or iso-C(15:0) 2-OH (35.0%), followed by C(16:0) (25.4%) and C(18:1)??7c (16.8%). These data suggest that strain M3-4(T) represents a novel species in genus Photobacterium, for which the name P. atrarenae sp. nov. is proposed. The type strain is M3-4(T) (= KCTC 23265(T)??=??NCAIM B 02414(T)).</P>
Mucilaginibacter angelicae sp. nov., isolated from the rhizosphere of Angelica polymorpha Maxim
Kim, Byung-Chun,Poo, Haryoung,Lee, Kang Hyun,Kim, Mi Na,Kwon, O-Yu,Shin, Kee-Sun Microbiology Society 2012 International journal of systematic and evolutiona Vol.62 No.1
<P>A Gram-negative-staining, non-motile rod, designated GG-w14<SUP>T</SUP>, was isolated from the rhizosphere of <I>Angelica polymorpha</I> Maxim. Phylogenetic analysis of 16S rRNA gene sequences revealed that the isolate belonged to the genus <I>Mucilaginibacter</I> and exhibited 93.9-97.4 % 16S rRNA gene sequence similarity with recognized members of the genus <I>Mucilaginibacter</I> (closest relative <I>Mucilaginibacter gossypii</I> Gh-67<SUP>T</SUP>). DNA-DNA relatedness between strain GG-w14<SUP>T</SUP> and <I>M. gossypii</I> KCTC 22380<SUP>T</SUP> was <41 %. Strain GG-w14<SUP>T</SUP> grew at 4-35 °C, at pH 5.0-8.0 and with 0-1 % (w/v) NaCl. The isolate hydrolysed casein, CM-cellulose and starch and contained menaquinone 7 as the major menaquinone. The major cellular fatty acids were summed feature 3 (C16 : 1ω7<I>c</I> and/or iso-C15 : 0 2-OH; 39.9 %), iso-C15 : 0 (24.2 %) and iso-C17 : 0 3-OH (12.4 %). The DNA G+C content was 42.5 mol%. These data suggest that strain GG-w14<SUP>T</SUP> should be considered as a representative of a novel species of the genus <I>Mucilaginibacter</I>, for which the name <I>Mucilaginibacter angelicae</I> sp. nov. is proposed. The type strain is GG-w14<SUP>T</SUP> ( = KCTC 23250<SUP>T</SUP> = NCAIM B 02415<SUP>T</SUP>).</P>
Lee, Jong-Soo,Poo, Haryoung,Han, Dong P.,Hong, Seung-Pyo,Kim, Kwang,Cho, Michael W.,Kim, Eun,Sung, Moon-Hee,Kim, Chul-Joong American Society for Microbiology 2006 Journal of virology Vol.80 No.8
<B>ABSTRACT</B><P>Induction of mucosal immunity may be important for preventing SARS-CoV infections. For safe and effective delivery of viral antigens to the mucosal immune system, we have developed a novel surface antigen display system for lactic acid bacteria using the poly-γ-glutamic acid synthetase A protein (PgsA) of <I>Bacillus subtilis</I> as an anchoring matrix. Recombinant fusion proteins comprised of PgsA and the Spike (S) protein segments SA (residues 2 to 114) and SB (residues 264 to 596) were stably expressed in <I>Lactobacillus casei</I>. Surface localization of the fusion protein was verified by cellular fractionation analyses, immunofluorescence microscopy, and flow cytometry. Oral and nasal inoculations of recombinant <I>L. casei</I> into mice resulted in high levels of serum immunoglobulin G (IgG) and mucosal IgA, as demonstrated by enzyme-linked immunosorbent assays using S protein peptides. More importantly, these antibodies exhibited potent neutralizing activities against severe acute respiratory syndrome (SARS) pseudoviruses. Orally immunized mice mounted a greater neutralizing-antibody response than those immunized intranasally. Three new neutralizing epitopes were identified on the S protein using a peptide neutralization interference assay (residues 291 to 308, 520 to 529, and 564 to 581). These results indicate that mucosal immunization with recombinant <I>L. casei</I> expressing SARS-associated coronavirus S protein on its surface provides an effective means for eliciting protective immune response against the virus.</P>