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Won, Eunsoo,Han, Kyu-Man,Kang, June,Kim, Aram,Yoon, Ho-Kyoung,Chang, Hun Soo,Park, Ji-Young,Lee, Min-Soo,Greenberg, Tsafrir,Tae, Woo-Suk,Ham, Byung-Joo Elsevier 2017 Progress in neuro-psychopharmacology & biological Vol.77 No.-
<P><B>Abstract</B></P> <P>The genetic variant of the vesicular monoamine transporter 1 gene (<I>VMAT1</I>) has been suggested to be associated with monoaminergic signaling and neural circuit activity related to emotion processing. We aimed to investigate microstructural changes in white matter tracts of patients with major depressive disorder (MDD), and examined the interaction effect between <I>VMAT1</I> Thr136Ile (rs1390938) polymorphism and MDD on white matter integrity. Diffusion tensor imaging (DTI) and <I>VMAT1</I> Thr136Ile (rs1390938) genotyping were performed on 103 patients diagnosed with MDD and 83 healthy control participants. DTI was used to investigate microstructural changes in white matter tracts in patients compared to healthy controls. The possible interaction effect between rs1390938 and MDD on white matter integrity was also assessed. Patients with MDD exhibited lower fractional anisotropy (FA) values of the forceps major (<I>p</I> <0.001), forceps minor (<I>p</I> =0.001), inferior longitudinal fasciculus (left: <I>p</I> =0.001; right: <I>p</I> <0.001), parietal endings of the superior longitudinal fasciculus (left: <I>p</I> <0.001; right: <I>p</I> =0.002), left temporal endings of the superior longitudinal fasciculus (<I>p</I> =0.001), and right uncinate fasciculus (<I>p</I> =0.001). Significant genotype-by-diagnosis interaction effects were observed on FA values of the right uncinate fasciculus (<I>p</I> =0.001), with A-allele carrier patients exhibiting lower FA values compared to G-allele homozygous patients (<I>p</I> =0.003). No significant differences in FA values were observed between genotype subgroups among healthy controls. Our results may contribute to the evidence indicating an association between the <I>VMAT1</I> gene and structural brain alterations in depression.</P> <P><B>Highlights</B></P> <P> <UL> <LI> <I>VMAT1</I> Thr136Ile (rs1390938) affects monoaminergic signaling and emotion processing. </LI> <LI> We investigated white matter integrity and its association with rs1390938 in MDD. </LI> <LI> MDD patients showed reduced FA in several white matter tracts. </LI> <LI> Genotype×diagnosis interaction effect was observed in FA of uncinate fasciculus. </LI> </UL> </P>
Ham, Won-Hun,Yang, Jae-Gwon,Lim, Tae-Gyun,Jung, Yun-Ho,Chung, Yun-Sung The Pharmaceutical Society of Korea 1994 Archives of Pharmacal Research Vol.17 No.2
The synthesis of 3a, 3b, 7a fro Benzpthiazepinone and 1,4-dihyropyridine derivatives is described. Benzothiazepinone nad 1,4-dihydropyridine derivatives were prepared according to literature procedure. The key reactions involve esterification and amidation of benzothize-pinone nad 1,4-dihydropyridine derivatives.
Ham, Kyung-Yuen,Jeon, Young-Cheol,Kang, Jin-Woo,Kim, Nam-Kyun,Lee, Won-Jae,Lee, Yang,Ryu, Sung-Ju,Yang, Hae-Hun Korean Mathematical Society 2008 대한수학회지 Vol.45 No.3
A ring R is called IFP, due to Bell, if ab=0 implies aRb=0 for $a,b{\in}R$. Huh et al. showed that the IFP condition need not be preserved by polynomial ring extensions. But it is shown that ${\sum}^n_{i=0}$ $E_{ai}E$ is a nonzero nilpotent ideal of E whenever R is an IFP ring and $0{\neq}f{\in}F$ is nilpotent, where E is a polynomial ring over R, F is a polynomial ring over E, and $a_i^{'s}$ are the coefficients of f. we shall use the term near IFP to denote such a ring as having place near at the IFPness. In the present note the structures of IFP rings and near-IFP rings are observed, extending the classes of them. IFP rings are NI (i.e., nilpotent elements form an ideal). It is shown that the near-IFPness and the NIness are distinct each other, and the relations among them and related conditions are examined.
Won, Eun-Soo,Chang, Hun-Soo,Lee, Hwa-Young,Ham, Byung-Joo,Lee, Min-Soo S. Karger 2012 Neuropsychobiology Vol.66 No.4
<P>Abstract</P><P><B><I>Objective:</I></B> Various studies have shown that short (s)/long (l) polymorphisms of the serotonin transporter-linked polymorphic region (5-HTTLPR) might predict treatment outcome to selective serotonin reuptake inhibitors. The purpose of this study was to evaluate the association between 5-HTTLPR and clinical response to escitalopram treatment in Korean subjects with major depressive disorder. <B><I>Methods:</I></B> One hundred and fifteen Korean patients diagnosed with major depressive disorder were evaluated during 8 weeks of escitalopram treatment at a dose of 5–20 mg/day. Patients were genotyped for 5-HTTLPR using polymerase chain reaction. Clinical symptoms were evaluated by the 21-item Hamilton Depression Rating (HAMD-21) scale during the 8 weeks of treatment. <B><I>Results:</I></B> Therapeutic response to antidepressant escitalopram was better in s allele carriers (ss, sl) than in l allele homozygotes (ll) at 8 weeks of treatment (OR = 6.24, p = 0.026). The proportion of s allele carriers in responders was higher than that in non-responders (96.6 vs. 85.7%). The percentile decline in HAMD-21 in s allele carriers (59.86 ± 3.23%) was larger than that in HAMD-21 in l allele homozygotes (43.13 ± 11.49%; p = 0.029). However, 5-HTTLPR genotypes were not significantly associated with remission (p > 0.05). <B><I>Conclusions:</I></B> Our results show that treatment response to escitalopram at 8 weeks was moderated by 5-HTTLPR, with better response rates for s allele carriers than for l allele homozygotes. Although the role of 5-HTTLPR as a definite predictor of selective serotonin reuptake inhibitor treatment response cannot be confirmed from current results, they do suggest a trend for better response in s allele carriers.</P><P>Copyright © 2012 S. Karger AG, Basel</P>
A Synthetic Approach Toward Neolemane
Ham, Won-Hun 成均館大學校 科學技術硏究所 1990 論文集 Vol.41 No.2
Neolemane의 합성에 기본골격인 6/8 bicyclic ring system(9)을 Key intermediate (10)를 aliphatic claisen rearrangement 반응을 이용하여 만들려고 시도하였다. 3-isobutoxy -5.6-dim-ethylcyclohex-2-en-1-one (13)과 여러 가지 alkylating reagentes(methyl acrylate, 3-[(Trimethylsily) oxy]-1-bromopropane, allye bromide, 3-butenyl chloride, and cis-3-chloroacrylate) 반응에서 합성된 물질들을 이용하여 Key intermediate (10)의 합성을 시도하였다. 위의 반응들의 반응성, 반응 조건 등을 상세히 서술하였다.
A Formal Total Synthesis of(±)-Ferruginine by Pd-catalyzed Intramolecular Aminocarbonylation
Ham, Won-Hun,Jung, Young Hoon,Lee, Kyunghae,Oh, Chang-Young,Lee, Kee-Young 성균관대학교 약학연구소 1997 成均藥硏論文集 Vol.9 No.1
A practical and efficient synthetic route to the neuroactive alkaloid ferruginine has been developed. 8-Azabicyclo[3. 2. 1]octane skeleton 4 was prepared in one step by intramolecular aminocarbonylation of 3 catalyzed by palladium.