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Needle Deflection during Insertion into Soft Tissue Based on Virtual Spring Model
Haiyan Du,Yongde Zhang,Jingang Jiang,Yanjiang Zhao 보안공학연구지원센터 2015 International Journal of Multimedia and Ubiquitous Vol.10 No.1
Needle insertion is the most common procedure of minimally invasive interventions. During insertion into a soft tissue, the needle with bevel tip can deflect due to the asymmetric forces acting on the tip of the needle. In this paper, a mechanics-based model is developed to predict the needle deflection. In the model, the needle is considered as a cantilever beam supported by a series of nonlinear springs each of which has stiffness different from each other. The value of stiffness can be calculated by cutting force acting on the needle tip. Based on the model and the analysis of cutting force and friction force, Rayleigh-Ritz method is used to estimate the amount of needle deflection. Experiment shows that the simulation model can accurately predict the deflection of the bevel-tipped needle.
The Value of Tumor Treating Fields in Glioblastoma
Zhang, Chaochao,Du, Jianyang,Xu, Weidong,Huang, Haiyan,Gao, Li The Korean Neurosurgical Society 2020 Journal of Korean neurosurgical society Vol.63 No.6
Glioblastoma (GBM) is one of the most common tumors of the central nervous system, which is the most lethal brain cancer. GBM treatment is based primarily on surgical resection, combined with radiotherapy and chemotherapy. Despite the positive treatment, progression free survival and overall survival were not significantly prolonged because GBM almost always recurs. We are always looking forward to some new and effective treatments. In recent years, a novel treatment method called tumor treating fields (TTFields) for cancer treatment has been proposed. TTFields devices were approved by the Food and Drug Administration (FDA) for adjuvant treatment of recurrent and newly diagnosed GBMs in 2011 and 2015, respectively. This became the first breakthrough treatment for GBM in the past 10 years after the FDA approved bevacizumab for patients with relapsed GBM in 2009. This paper summarized the research results of TTFields in recent years and elaborated the mechanism of action of TTFields on GBM, including cell and animal experimental research, clinical application and social benefits.
Protein Binding Study of S-Ibuprofen Using High-Performance Frontal Analysis
Longmei Jin,Du Young Choi,Haiyan Liu,Kyung Ho Row* 대한화학회 2005 Bulletin of the Korean Chemical Society Vol.26 No.1
High-performance frontal analysis (HPFA) was used for the determination of the binding constant of Sibuprofen to human serum albumin (HSA). This experiment was based on an Inertsil 100 Diol 5 column and sodium phosphate buffer (pH 7.4 and ionic strength of 0.17) as the mobile phase. The mixture of S-ibuprofen and HSA (70 μM) solution were directly injected into the HPFA column. An injection volume of 200 μL and a “restricted injection” method were applied to ensure the drug to be eluted as a zonal peak with a plateau. The unbound drug concentration was calculated from the peak height of the zonal peak. Scatchard analysis was used for evaluation of the binding constant (K) and binding affinity (nK) of S-ibuprofen to HSA, and the results were K = 2.833 × 104 [L mol−1], nK = 4.935 × 104 [L mol−1], respectively.
Protein Binding Study of S-Ibuprofen Using High-Performance Frontal Analysis
Jin, Longmei,Choi, Du-Young,Liu, Haiyan,Row, Kyung-Ho Korean Chemical Society 2005 Bulletin of the Korean Chemical Society Vol.26 No.1
High-performance frontal analysis (HPFA) was used for the determination of the binding constant of Sibuprofen to human serum albumin (HSA). This experiment was based on an Inertsil 100 Diol 5 column and sodium phosphate buffer (pH 7.4 and ionic strength of 0.17) as the mobile phase. The mixture of S-ibuprofen and HSA (70 $\mu$M) solution were directly injected into the HPFA column. An injection volume of 200 $\mu$L and a “estricted injection”method were applied to ensure the drug to be eluted as a zonal peak with a plateau. The unbound drug concentration was calculated from the peak height of the zonal peak. Scatchard analysis was used for evaluation of the binding constant (K) and binding affinity (nK) of S-ibuprofen to HSA, and the results were K = 2.833 ${\times}$ 10$^4$ [L mol$^{-1}$], nK = 4.935 ${\times}$ 10$^4$ [L mol$^{-1}$], respectively.
Jing Wang,Long Liu,Haiyan Zhou,Jianghua Li,Guocheng Du,Jian Chen 한국생물공학회 2011 Biotechnology and Bioprocess Engineering Vol.16 No.5
High cell density cultivation was investigated for L-phenylalanine (L-Phe) production by an L-tyrosine (L-Tyr) auxotrophic Escherichia coli WSH-BR165 (pAPB03). Dual exponential feeding of L-Tyr and glucose was adopted to achieve high cell density cultivation. The control was completed without dual feeding. The processes where dual feeding and induction were commenced together and those where induction began after dual feeding were studied and compared. The results indicated that the former dual feeding mode was most favorable for enhanced L-Phe production. With an optimal specific growth rate of 0.09/h during the dual exponential feeding period, the maximum dry cell weight reached 43.16 g/L (3.04 times that of the control) with a final L-Phe titer of 44.53 g/L (1.06 times that of the control) and an L-Phe productivity of 1.484 g/L/h (1.69 times that of the control). High cell density cultivation via the feeding of L-Tyr and glucose exponentially after the induction point proved to be an efficient approach to enhance L-Phe production.