Rheinic acid ameliorates radiation‑induced acute enteritis in rats through PPAR‑γ/NF‑κB

Haixia Sha,Yu Gu,Weixing Shen,Li Zhang,Fei Qian,Yudong Zhao,Haixiao Li,Ting Zhang,Weimin Lu 한국유전학회 2019 Genes & Genomics Vol.41 No.8

Background Acute radiation enteritis (ARE), a common complication of intestinal caused by abdominal and pelvic radiation therapy. Rheinic acid is a major active ingredient derived from Rhubarb. Rhubarb could suppress inflammation, tumor, fibrosis oxidative damage. However, RA as the main active component and extract monomer of Rhubarb, the pharmacological activity and the underlying molecular mechanism on various diseases has not yet been revealed. Objective To determine the potential role of rheinic acid (RA) in ameliorating inflammation of rats with acute radiation enteritis (ARE), and explore the underlying mechanism. Methods ARE rat model was established by irradiated with single-dose 10 Gy X-rays at a rate of 0.62 Gy/min to the abdomen. The rats were executed after orally administered with Rheinic acid 7 days and used in the subsequent experiments. Body weight, fecal characteristics and bloody of rats were used to assess the disease activity index. Histological analysis of the jejunum and colon were evaluated using H&E staining. The pro-inflammatory cytokines levels were measured by immunohistochemistry and ELISA. The levels of nitric oxide (NO), malondialdehyde (MDA), superoxide dismutase (SOD) and glutathione (GSH) were also determined. The mRNA and protein expression were examined by real-time polymerase chain reaction (qRT-PCR) and western blot, respectively. Results Rheinic acid promoted intestinal functional recovery, and ameliorated intestinal damage and bloody stool in ARE rats. Rheinic acid strongly decreased the levels of tumor necrosis factor-α, interleukin-1, interleukin-6, NO, and MDA, whereas increased levels of anti-oxidants, SOD and GSH. Moreover, the expression of apoptosis-related proteins, cleaved caspase-3 and cleaved poly (ADP-ribose) polymerase (PARP), were decreased with RA treatment. Further study indicated that PPAR-γ was activated and thereby NF-κB and p38 MAPK signaling pathway were suppressed after rheinic acid treatment. Conclusion Rheinic acid could ameliorate acute radiation enteritis and the underlying molecular mechanism is, at least partially, through PPAR-γ/NF-κB and p38 MAPK/JNK pathways.

Further Study on Networked Control Systems with Unreliable Communication Channels

Xiao Lu,Na Wang,Qingyuan Qi,Xiao Liang,Haixia Wang 제어·로봇·시스템학회 2021 International Journal of Control, Automation, and Vol.19 No.1

This paper focuses on the fundamental problems of linear quadratic gaussian (LQG) control and stabilization problems for networked control systems (NCSs) with unreliable communication channels (UCCs) wherepacket dropout, input delay and observation delay occur. These basic issues have attracted extensive attentions dueto broad applications. Our contributions are as follows. For the finite horizon case, without time-stamping technique, the optimal estimator is derived by using the novelty method of innovation sequences based on the delayedintermittent observations; A necessary and sufficient condition for the optimal control problem is presented on thebasis of the solution to the forward and backward difference equations (FBDEs) and two coupled Riccati equations. For the infinite horizon case, it is shown that under certain assumption, the system can stay bounded in the meansquare sense if and only if the algebraic Riccati equation admits the unique positive solution.

Necessary and Sufficient Condition of Optimal Control for Networked Control Systems with Markovian Packet Dropouts

Xiao Lu,Yuanyu Cai,Guilin Zhang,Hongxia Wang,Haixia Wang,Xiao Liang 제어·로봇·시스템학회 2023 International Journal of Control, Automation, and Vol.21 No.5

This paper considers optimal control problem for networked control systems (NCSs) with Markovian packet dropouts. Since previous literatures generally consider the one-way Markovian packet dropouts, i.e., from the sensor to the estimator or from the controller to the actuator. To make a further study of this issue, we aim to give the complete solution to the control problem of the two-way Markovian packet dropouts, i.e., from the sensor to the estimator and from the controller to the actuator. Firstly, by applying the Pontryagin’s maximum principle and mathematical induction method, a solution to the forward and backward stochastic difference equations (FBSDEs) is derived. Secondly, in virtue of the solution to the FBSDEs, we obtain the necessary and sufficient condition for the optimal control problem. Thirdly, the optimal controller is given based on the complete square method. Finally, numerical examples are proposed to illustrate the effectiveness of the theoretical results.

Influence of Coastal Wind on Surface Ozone and Nitrogen Oxides in Suburban Shanghai

Wenpo Shan,Peng Yang,Haixia Lu,Kefeng Ma,Zhixin Huang 한국기상학회 2016 Asia-Pacific Journal of Atmospheric Sciences Vol.52 No.5

Surface ozone, NO, NO2, and NOx were measured at a coastal site (Shihua) and a nearby inland site (Zhujing) in suburban Shanghai for the whole year of 2009. More days with ozone pollution in a longer time range were observed at the coastal site than the inland site. The diurnal variations of NOx concentrations were obviously higher at Zhujing station, while those of ozone concentrations were higher at Shihua station, indicating their different air pollution conditions. Coastal wind has significant influence on the levels and characteristics of the air pollutants. The ozone concentrations during maritime winds (MW) were much higher than those during continental winds (CW) at each of the site, while the NO and NO2 concentrations were both opposite. The ozone concentrations at Shihua station were much higher than those at Zhujing station, while the NO and NO2 concentrations were both opposite. The ozone concentrations at both of the two sites showed a distinct “weekend effects” and “weekdays effects” patterns during CW and MW, respectively. Correlation analysis of the pollutants showed that, the compounds during MW were more age than those during CW, and the compounds at Shihua were more age than those at Zhujing. The air pollutions at both of the two sites are mainly associated with the pollutants emitted in this region instead of long range transport.

Recognizing and Predicting the Non-Performing Loans of Commercial Banks

Zhang Yu,Guan Yongsheng,Yu Gang,Lu Haixia 보안공학연구지원센터 2016 International Journal of Signal Processing, Image Vol.9 No.11

As the reform and opening up going into depth over the past three decades and more, the market economic system has been gradually established. The banking industry grows steadily in the process of the reform. It supports economic development, reduces and defends many financial risks in the processof the reform. However, there are many kinds of risks inside of banks, one of which is that the non-performing loans (NPLs) ratio is too high. Therefore, people should focus on how to accurately classify the banking loans into performing and non-performing ones and how to control and prevent the resulting crisis. This paper deeply analyses China’s NPLs problem for the current period, recognizes and classifies loans types by adopting decision trees, Naïve Bayes and support vector machine (SVM) methods. The experiment result found that the decision trees method can well identify the performing loans and non-performing loans; its accuracy is as high as 94%.

Optimal LQG Control for Networked Control Systems with Remote and Local Controllers

Xiao Liang,Juanjuan Xu,Xiao Lu,Qingyuan Qi,Haixia Wang,Rong Gao 제어·로봇·시스템학회 2020 International Journal of Control, Automation, and Vol.18 No.1

We consider the finite horizon optimal LQG control problem for networked control systems with a remote controller, a local controller and communication channels with packet dropouts and transmission delays. The local controller can directly observe state signals and send them to the remote controller via a packet-dropout channel. Then the remote controller sends the received measurement signals to the local controller. Afterwards, the two controllers operate the plant through a delayed channel. The contributions of this paper are as follows: Firstly, at the side of the remote controller, we develop an optimal estimator to show that the separation principle holds. Secondly, we derive a non- homogeneous relationship between the state and the costate of systems in virtue of the maximum principle. Finally, a necessary and sufficient condition for the optimal control problem is derived in terms of the two coupled Riccati equations. Numerical examples are employed to illustrate the theoretical results.

Optimal Control and Stabilization for Networked Control Systems Subject to Intermittent Observations and One-step Delayed Measurement

Na Wang,Chuanzhi Lv,Xiao Liang,Haixia Wang,Xiao Lu 제어·로봇·시스템학회 2023 International Journal of Control, Automation, and Vol.21 No.4

This paper concerns the control problem for networked control systems (NCSs) with local and remote controllers (LRC) subject to one-step delay and intermittent observations. The main contributions lie in two aspects. Firstly, for the finite-horizon case, applying the maximum principle and the completing square, a necessary and sufficient condition is derived for the solvability of the optimal control problem. Meanwhile, we obtain the explicit controller which is a linear function of the optimal state estimator, with the feedback gain based on the coupled Riccati equations. Secondly, for the infinite-horizon case, a necessary and sufficient condition of the stabilization in the mean square sense for the system without additive noise is derived and a sufficient condition is developed for the boundedness in the mean square sense of the system with the additive noise. Numerical examples are given to show that the proposed algorithms are valid.

The influence of high-temperature nitridation process on the crystalline quality of semipolar (1122) GaN epitaxial films

Li Wenlong,Wang Lianshan,Chai Ruohao,Wen Ling,Lu Haixia,Wang Huanhua,Yang Shaoyan,Sun Wenhong 한국물리학회 2022 Current Applied Physics Vol.39 No.-

Semipolar (1122) GaN epitaxial films were grown on m-plane sapphire substrates by metal-organic chemical vapor deposition and additional high-temperature nitridation was introduced during the growth. The growth mechanism, surface microtopography, and the full width at half maximum (FWHM) of X-ray rocking curves (XRCs) of on-axis and off-axis (1122) GaN planes were investigated. The results demonstrate that additional high-temperature nitridation process could reduce surface roughness and anisotropy, and suppress the other orientations, and partially improve the crystalline quality of (1122) GaN epitaxial films. The XRCs FWHM of the off-axis (1122) GaN planes decrease and show a different varying tendency after additional high-temperature nitridation process associated with the partial dislocations and basal plane stacking faults (BSFs). The results of the modified Williamson-Hall (W–H) analysis and photoluminescence spectrum show the BSFs increased while the partial dislocations decreased after an additional high-temperature nitridation process. The improvement of crystalline quality was mainly correlated to the reduction of partial dislocations.

Neuroprotective effect of green tea extractives against oxidative stress by enhancing the survival and proliferation of PC12 cells

Zhenlu Cai,Xiaoxuan Hu,Ruolan Tan,Yunran Feng,Meiqi Sun,Ning Ma,Xingxing Li,Li Huang,Jing An,Qian Ge,Haixia Lu 대한독성 유전단백체 학회 2019 Molecular & cellular toxicology Vol.15 No.4

Backgrounds: Previous studies were mainly focused on the effect of catechins and caffeine, the main pharmacological ingredients of green tea. However, the ordinary way of taking green tea is by drinking the tea water. Hence the benefits of water extractives of green tea were investigated in the current study. Methods: H2O2 was applied to induce the oxidative stress on PC12 cells. The neuroprotective effects of green tea against oxidative stress were determined by observing the biological behaviors of PC12 cells. Results: With the pre-treatment of light green tea, the survival and proliferation of oxidative stressed PC12 cells were significantly enhanced. H2O2 induced PC12 cell apoptosis was completely reversed. Consistently, the expression of JNK was up-regulated while the caspase-3 was down-regulated. Conclusion: These results suggested that drinking green tea, particularly the light green tea, performed neuroprotective effects against oxidative stress.