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RISS 인기검색어
- 검색키워드
- 저자 : Haidong Zhao (검색결과 4 건)
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- 유료
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Wang, Haidong,Li, Deyuan,Hu, Zhongze,Zhao, Siming,Zheng, Zhejun,Li, Wei Korean Society for Molecular and Cellular Biology 2016 Molecules and cells Vol.39 No.6
To investigate the potential therapeutic effects of polyphenols in treating Pb induced renal dysfunction and intoxication and to explore the detailed underlying mechanisms. Wistar rats were divided into four groups: control groups (CT), Pb exposure groups (Pb), Pb plus Polyphenols groups (Pb+PP) and Polyphenols groups (PP). Animals were kept for 60 days and sacrificed for tests of urea, serum blood urea nitrogen (BUN) and creatinine. Histological evaluations were then performed. In vitro studies were performed using primary kidney mesangial cells to reveal detailed mechanisms. Cell counting kit-8 (CCK-8) was used to evaluate cell viability. Pb induced cell apoptosis was measured by flow cytometry. Reactive oxygen species (ROS) generation and scavenging were tested by DCFH-DA. Expression level of tumor necrosis factor-${\alpha}$ (TNF-${\alpha}$), interleukin-1-${\beta}$ (IL-1-${\beta}$) and IL-6 were assayed by ELISA. Western blot and qPCR were used to measure the expression of ERK1/2, JNK1/2 and p38. Polyphenols have obvious protective effects on Pb induced renal dysfunction and intoxication both in vivo and in vitro. Polyphenols reduced Pb concentration and accumulation in kidney. Polyphenols also protected kidney mesangial cells from Pb induced apoptosis. Polyphenols scavenged Pb induced ROS generation and suppressed ROS-mediated ERK/JNK/p38 pathway. Downstream pro-inflammatory cytokines were inhibited in consistency. Polyphenol is protective in Pb induced renal intoxication and inflammatory responses. The underlying mechanisms lie on the antioxidant activity and ROS scavenging activity of polyphenols.
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A Sample-Reducing Approach for Training Support Vector Machines (SVMs)
Shipin Lv,Haidong Zhao,Xiukun Wang 한국멀티미디어학회 2006 한국멀티미디어학회 국제학술대회 Vol.2006 No.-
The paper presents a novel approach to cut down the number of samples before training SVMs. It proves, among those samples that are collinear in the reproduced kernel feature space, only the two end points are useful for solving the SVM QP classification problem. By using 'kernel trick', those useless data points could be found out in the original space and removed from training samples. It brings twofold benefits: decrease in the number of samples and increase in the sparseness.
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Under-Oil Superhydrophilic and Flame-Retardant Fabrics for Water Removal from Oil
Sida Fu,Haidong Li,Yue Jiang,Yan Zhao,Zhiguang Xu 한국섬유공학회 2023 Fibers and polymers Vol.24 No.8
In this study, superamphiphilic fabrics with under-oil superhydrophilic property have been prepared using trimesoyl chloride (TMC), tetrakis(hydroxymethyl) phosphonium chloride (THPC), and urea as coating materials. Owing to the unique under-oil superhydrophilicity, the coated fabric is able to absorb water droplets dispersed in oil, and oil stains on the coated fabric (dry) can be easily cleaned off just by rinsing with water (without the use of detergent), showing strong anti-oil-fouling ability. The coating is durable enough to withstand at least 50 cycles of home laundering, 1000 cycles of Martindale abrasions, as well as acid/base etching for 12 h without losing its under-oil superhydrophilic property. Meanwhile, the coated fabric exhibits excellent flame-retardant properties, with an oxygen limiting index (LOI) of 39.5% and a char length of 8.5 cm in vertical flame test. This multi-functional coating may find wide applications in functional textiles, water recovery, and flame-retardant field.
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Wei Li,Haidong Wang,Deyuan Li,Zhongze Hu,Siming Zhao,Zhejun Zheng 한국분자세포생물학회 2016 Molecules and cells Vol.39 No.6
To investigate the potential therapeutic effects of polyphenols in treating Pb induced renal dysfunction and intoxication and to explore the detailed underlying mechanisms. Wistar rats were divided into four groups: control groups (CT), Pb exposure groups (Pb), Pb plus Polyphenols groups (Pb+PP) and Polyphenols groups (PP). Animals were kept for 60 days and sacrificed for tests of urea, serum blood urea nitrogen (BUN) and creatinine. Histological evaluations were then performed. In vitro studies were performed using primary kidney mesangial cells to reveal detailed mechanisms. Cell counting kit-8 (CCK-8) was used to evaluate cell viability. Pb induced cell apoptosis was measured by flow cytometry. Reactive oxygen species (ROS) generation and scavenging were tested by DCFH-DA. Expression level of tumor necrosis factor- (TNF-), interleukin-1- (IL-1-) and IL-6 were assayed by ELISA. Western blot and qPCR were used to measure the expression of ERK1/2, JNK1/2 and p38. Polyphenols have obvious protective effects on Pb induced renal dysfunction and intoxication both in vivo and in vitro. Polyphenols reduced Pb concentration and accumulation in kidney. Polyphenols also protected kidney mesangial cells from Pb induced apoptosis. Polyphenols scavenged Pb in-duced ROS generation and suppressed ROS-mediated ERK/JNK/p38 pathway. Downstream pro-inflammatory cytokines were inhibited in consistency. Polyphenol is protective in Pb induced renal intoxication and inflammatory responses. The underlying mechanisms lie on the antioxidant activity and ROS scavenging activity of polyphenols.
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