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H. Han(한호현),Y. Park(박예진),Y. Choi(최유미),U. Yong(용의중),B. Kang(강병민),W. Shin(신우정),S. Min(민소연),H. J. Kim(김현중),J. Jang(장진아) Korean Society for Precision Engineering 2021 한국정밀공학회 학술발표대회 논문집 Vol.2021 No.11월
Intestinal disease is a global health problem affecting millions of people. To investigate therapeutic compounds and unveil the mechanisms of the diseases, numerous in vitro intestine models have been developed as alternatives to animal surrogates. Intestinal organoids have shown that they can emulate major human physiology, but it is difficult to control their growth and maturation. On the other hand, microphysiological systems (MPSs) have been enabled to recapitulate intestinal tissues in vitro and its ecosystem with commensal microbiomes, their geometrical complexity is limited to 2D or 2.5D architectures. For this reason, 3D bioprinting has gained growing interest since it can be used to mimic 3D complex physiology such as cell-cell or cell-matrix interaction. Here, we bioprinted a tubular intestine model using a colon-derived decellularized extracellular matrix (Colon dECM). We observed that Colon dECM promotes spontaneous maturation of intestinal epithelial cells, especially its enteroendocrine functions. Furthermore, the 3D bioprinted tubular model with a hollow lumen showed cellular maturation and self-organization demonstrating distinctive tissue morphogenesis. We envisage this advanced in vitro intestine model as a platform to study intestinal morphogenesis, disease, and treatments.
X-선 회절 분석법을 이용한 Li₂O-SiO₂ 결정화유리계에서의 결정상의 정량적 고찰
한호현,이성한,류봉기 부산대학교 1995 生産技術硏究所論文集 Vol.48 No.-
Determination of crystallinity of glass-ceramic or estimation of the amount of residual glass in sintered body is important for understanding of characteristic of materials. Cristallinity measure by XRD method has been successfully used to determine the exact and effective quantitative values and is able to catch very small change of compositions. In this study, precedent XRD methods was reveiwed and effects of variable factors were investigated in 30Li₂O·70SiO₂ glass-ceramic. Olberg's method was useful in samples which have crystal orientation or wide particle distribution. In the case of considering of mass absorption coefficient, the difference of crystallinity was less than 4wt%. 결정화유리에서 소정의 결정질의 양을 측정하거나, 소결체 내에서 잔류 유리의 양을 측정하는 것은 그 물성을 이해하는데 매우 중요하다. XRD법에 의한 결정화도 측정은 정확하고 유효한 정량치 및 미세한 조성 변화도 측정 가능하다. 본 연구에서는 30Li₂O·70SiO₂의 결정화 유리를 대상으로, 기존의 XRD 법을 재검토하고 여러 factor 들의 영향을 조사하였다. 방향성과 입도분포차가 큰 시료에서는 Ohlberg법이 더 용이 하며, 흡수계수를 고려한 경우 4wt% 내의 적은 오차를 보였다.