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Gweon, Tae-Geun,Kim, Jinsu,Lim, Chul-Hyun,Park, Jae Myung,Lee, Dong-Gun,Lee, In Seok,Cho, Young-Seok,Kim, Sang Woo,Choi, Myung-Gyu Hindawi Publishing Corporation 2016 Gastroenterology Research and Practice Vol.2016 No.-
<P><I>Background and Aims</I>. Fecal microbiota transplantation (FMT) is a highly effective treatment option for refractory<I> Clostridium difficile</I> infection (CDI). FMT may be challenging in patients with a low performance status, because of their poor medical condition. The aims of this study were to describe our experience treating patients in poor medical condition with refractory or severe complicated CDI using FMT via the upper GI tract route.<I> Methods</I>. This study was a retrospective review of seven elderly patients with refractory or severe complicated CDI and a poor medical condition who were treated with FMT through the upper GI tract route from May 2012 through August 2013. The outcomes studied included the cure rate of CDI and adverse events.<I> Results</I>. Of these seven patients who received FMT via the upper GI tract route, all patients were cured. During the 11-month follow-up period, CDI recurrence was observed in two patients; rescue FMT was performed in these patients, which led to a full cure. Vomiting was observed in two patients.<I> Conclusions</I>. FMT via the upper gastrointestinal tract route may be effective for the treatment of refractory or severe complicated CDI in patients with a low performance status. Physicians should be aware of adverse events, especially vomiting.</P>
Gweon, Tae-Geun,Kim, Sang Woo,Noh, Yong-Sun,Hwang, Seawon,Kim, Na-Young,Lee, Yoonbum,Lee, Soon-Wook,Lee, Sung Won,Lee, Jong Yul,Lim, Chul-Hyun,Hun Kim, Hyung,Kim, Jin Su,Kyung Cho, Yu,Myung Park, Jae Wolters Kluwer Health 2015 Medicine Vol.94 No.13
<P><B>Abstract</B></P><P>For afternoon colonoscopy, same-day administration of sodium picosulfate, magnesium oxide, and citric acid (PM/Ca) is recommended. However, few studies have evaluated the bowel-cleansing efficacy and safety of this regimen. The aim of this study was to compare the bowel-cleansing efficacy, side effects, and patient's tolerability of a same-day split administration of PM/Ca with polyethylene glycol (PEG) for afternoon colonoscopy.</P><P>Patients were randomly assigned to a PM/Ca group or a PEG group. The PM/Ca group consumed 1 sachet of PM/Ca at 06:00 and 1 sachet of PM/Ca 4 hours before the colonoscopy. They also took 2 tablets of bisacodyl before sleep on the night before. The PEG group consumed 2 L of PEG at 06:00 and 2 L of PEG 4 hours before the colonoscopy. All subjects were instructed to finish the bowel cleanser or fluid at least 2 hours before colonoscopy. All colonoscopic examinations were performed in the afternoon on the same day. The bowel-cleansing efficacy was scored using 2 scales: the Ottawa Bowel Preparation Scale (OBPS) and the Aronchick scale. Ease of using the bowel cleanser was rated from 1 (very easy) to 5 (very difficult).</P><P>Two hundred nine patients underwent colonoscopy. The bowel-cleansing scores by OBPS did not differ between groups (5.0 vs 4.9, <I>P</I> = 0.63). Ease of using the bowel cleanser was superior in the PM/Ca group (<I>P</I> < 0.01).</P><P>The cleansing efficacy of PM/Ca administered on the day of colonoscopy is comparable to that of PEG. Patients prefer PM/Ca.</P>
Gweon-Young Ryu,Jung-Hyu Shin Korean Chemical Society 1993 Bulletin of the Korean Chemical Society Vol.14 No.5
The discrete structure of substituted 9-benzonorbornenyl cation 3a and 3c was studied using the empirical ${\Delta}$J equation which was developed by Kelly and coworker$^5$. The ${\Delta}$J values of substituted 9-benzonorbornenyl cations were obtained from p-methyl-6,7-dimethyl benzonorbornen-9-yl (3a) and 9-methyl-6,7-dimethyl benzonorbonen-9-yl (3c) cations under stable ion conditions, and were compared with those of the corresponding ketone analog; these cations were generated by dissolving the corresponding carbinols in superacid at -120$^{\circ}$C and the nmr spectra taken at -60$^{\circ}$C~-90$^{\circ}$C. The ${\Delta}$J values are 8.7 Hz for the bridgehead carbons in cation 3c and 3.1 Hz for cation 3b. The ${\Delta}$J values at C5,8 in fused benzene ring are 14.3 Hz for cation 3c and 8.7 Hz for cation 3a. The excellent correlation of the ${\Delta}$J values with 1$^9F$ chemical shifts of p-fluorophenyl-6,7-dimethylbenzonorbornenyl cation (3d) indicate that ${\Delta}$J value is a reliable probe to charge density at adjacent cationic carbon. These NMR parameters strongly support that the symmetrically ${\pi}$-bridged nonclassical structure (type 2) of substituted 9-benzonorbornenyl cations in stable ion conditions.
Prolongation of Neuromuscular Block of Succinylcholine Chloride by Ketamine in Rabbits
Gweon, Kyeong Deog,Chung, Woon Hyok CATHOLIC MEDICAL CENTER 1980 Bulletin of the Clinical Research Institute Vol.8 No.1
The effect of ketamine on the muscle relaxation produced by succinylcholine chloride was studied. The cause of prolongation of neuromuscular block of succinylcholine chloride by ketamine was discussed. The clinical dose of S.C.C. should be carefully adjusted, if ketamine would be administered.
Gweon, Hyung Keun,Lim, Sang Ho Institute of Pure and Applied Physics 2018 Japanese Journal of Applied Physics Vol. No.
<P>In Pt/Co/MgO trilayers, the contribution to the total perpendicular magnetic anisotropy from the bottom Pt/Co interface is significantly greater than that from the top Co/MgO interface at intermediate annealing temperatures. However, the relative contribution is reversed at the highest annealing temperature examined in this study, 400 degrees C. These results indicate that as the annealing temperature increases, the quality of the Pt/Co interface deteriorates owing to the intermixing of Pt and Co, whereas the quality of the Co/MgO interface improves as oxygen atoms, which are interpenetrated into the Co layer during the deposition of MgO, are diffused toward the Co/MgO interface. (C) 2018 The Japan Society of Applied Physics</P>
Hematologic diseases: high risk of Clostridium difficile associated diarrhea.
Gweon, Tae-Geun,Choi, Myung-Gyu,Baeg, Myong Ki,Lim, Chul-Hyun,Park, Jae Myung,Lee, In Seok,Kim, Sang Woo,Lee, Dong-Gun,Park, Yeon Joon,Lee, Jong Wook WJG Press 2014 WORLD JOURNAL OF GASTROENTEROLOGY Vol.20 No.21
<P>To investigate the incidence and clinical outcome of Clostridium difficile (C. difficile) associated diarrhea (CDAD) in patients with hematologic disease.</P>
Gweon Bomi,Jang Tae-Kyu,Thuy Pham Xuan,Moon Eun-Yi 한국응용약물학회 2022 Biomolecules & Therapeutics(구 응용약물학회지) Vol.30 No.2
The airway epithelium is equipped with the ability to resist respiratory disease development and airway damage, including the migration of airway epithelial cells and the activation of TLR3, which recognizes double-stranded (ds) RNA. Primary cilia on airway epithelial cells are involved in the cell cycle and cell differentiation and repair. In this study, we used Beas-2B human bronchial epithelial cells to investigate the effects of the TLR3 agonist polyinosinic:polycytidylic acid [Poly(I:C)] on airway cell migration and primary cilia (PC) formation. PC formation increased in cells incubated under serum deprivation. Migration was faster in Beas-2B cells pretreated with Poly(I:C) than in control cells, as judged by a wound healing assay, single-cell path tracking, and a Transwell migration assay. No changes in cell migration were observed when the cells were incubated in conditioned medium from Poly(I:C)-treated cells. PC formation was enhanced by Poly(I:C) treatment, but was reduced when the cells were exposed to the ciliogenesis inhibitor ciliobrevin A (CilioA). The inhibition of Beas-2B cell migration by CilioA was also assessed and a slight decrease in ciliogenesis was detected in SARS-CoV-2 spike protein (SP)-treated Beas-2B cells overexpressing ACE2 compared to control cells. Cell migration was decreased by SP but restored by Poly(I:C) treatment. Taken together, our results demonstrate that impaired migration by SP-treated cells can be attenuated by Poly(I:C) treatment, thus increasing airway cell migration through the regulation of ciliogenesis.
Gweon-Young Ryu,Jung-Hyu Shin Korean Chemical Society 1991 Bulletin of the Korean Chemical Society Vol.12 No.2
The $^{13}C-NMR$ shifts of a series of para-substituted $8-aryl-tricyclo[3.2.1.0^{2,7}]oct-8-yl$ and $9-aryl-tricyclo[3.3.1.0^{2,8}]-non-9-yl$ cations were measured in $FSO_3H/SO_2ClF\ at\-90^{\circ}$ in order to examine whether the ${\rho}^{C^+}$ values can be used as a measure of the geometric influence on the charge delocalization resulting from ${\rho}$ conjugation in rigid tricyclopropylcarbinyl cations. Plot of the ${\Delta}{\delta}^{C+} shifts against the ${\sigma}^{C+}$ constants revealed excellent linear correlation. The 8-aryl tricyclooctyl systems yielded a ${\rho}^{C+}$ value of -5.00 with r = 0.9962. Previous investigation of the 9-aryl-tricyclononyl systems gave a correlation coefficient of r = 0.9948 with a slope of ${\rho}^{C+}$ = -4.95. A fair parallelism exists between the results of $^{19}F-NMR $ studies and the change of ${\rho}^{C+}$ value in these cations. Consequently, it is established that the ${\rho}^{C+}$ value can be used to explain the mechanism of charge stabilization of the rigid cyclopropylcarbinyl cation such as tricyclo $[3.2.1.0^{2,7}]oct-8-yl$ cation.