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Guru Karthikeyan Thirunavukkarasu,G.R. Nirmal,이황재,이민규,박인규,이재영 한국공업화학회 2019 Journal of Industrial and Engineering Chemistry Vol.69 No.-
Dual cancer therapy is an attractive strategy that can generate synergistic effects and also reduce drug-related side effects. Here, we developed multifunctional nanocomplexes capable of remote on-demand production of hyperthermia and free radicals in response to near infrared (NIR) light irradiation To this end, thermal initiator and gold nanorods were embedded in nano-sized temperature-responsive poly(lactic acid-co-glycolic acid). In vitro studies demonstrated controllable heat and radical production from the nanocomplexes with NIR and effective eradication of CT26 colon cancer cells with our nanocomplexes. Hence, our smart nanomaterial will potentially contribute precise and effective dual cancer treatment.
Magnetic field-inducible drug-eluting nanoparticles for image-guided thermo-chemotherapy
Thirunavukkarasu, Guru Karthikeyan,Cherukula, Kondareddy,Lee, Hwangjae,Jeong, Yong Yeon,Park, In-Kyu,Lee, Jae Young Elsevier 2018 Biomaterials Vol.180 No.-
<P><B>Abstract</B></P> <P>Multifunctional nanoparticles integrating cancer cell imaging and treatment modalities into a single platform are recognized as a promising approach; however, their development currently remains a challenge. In this study, we synthesized magnetic field-inducible drug-eluting nanoparticles (MIDENs) by embedding superparamagnetic iron oxide nanoparticles (Fe<SUB>3</SUB>O<SUB>4</SUB>; SPIONs) and cancer therapeutic drugs (doxorubicin; DOX) in a temperature-responsive poly (lactic-co-glycolic acid) (PLGA) nanomatrix. Application of an external alternating magnetic field (AMF) generated heat above 42 °C and subsequent transition of the PLGA polymer matrix (T<SUB>g</SUB> = 42–45 °C) from the glassy to the rubbery state, facilitating the controlled release of the loaded DOX, ultimately allowing for simultaneous hyperthermia and local heat-triggered chemotherapy for efficient dual cancer treatment. The average size of the synthesized MIDENs was 172.1 ± 3.20 nm in diameter. <I>In vitro</I> studies showed that the MIDENs were cytocompatible and especially effective in destroying CT26 colon cancer cells with AMF application. <I>In vivo</I> studies revealed that the MIDENs enabled enhanced T<SUB>2</SUB> contrast magnetic resonance imaging and a significant suppression of malignant tumor growth under an AMF. Our multifunctional MIDENs, composed of biocompatible substances and therapeutic/imaging modalities, will be greatly beneficial for cancer image-guided thermo-chemotherapy applications.</P>
Rajendrakumar, Santhosh Kalash,Venu, Akhil,Revuri, Vishnu,George Thomas, Reju,Thirunavukkarasu, Guru Karthikeyan,Zhang, Jun,Vijayan, Veena,Choi, Seok-Yong,Lee, Jae Young,Lee, Yong-Kyu,Jeong, Yong Yeon American Chemical Society 2019 MOLECULAR PHARMACEUTICS Vol.16 No.5
<P>Tailoring combinatorial therapies along with real-time monitoring strategies has been the major focus of overcoming multidrug resistance in cancer. However, attempting to develop a multifunctional nanoplatform in a single construct leads to compromising therapeutic outcomes. Herein, we developed a simple, theranostic nanoassembly containing a hyaluronic acid-stabilized redox-sensitive (HART) polyethylenimine polyplex composed of a doxorubicin (DOX) intercalated Bcl-2 shRNA encoded plasmid along with a green-synthesized hausmannite (Mn<SUB>3</SUB>O<SUB>4</SUB>) and hematite (Fe<SUB>3</SUB>O<SUB>4</SUB>) nanoparticle (GMF). The highly stable HART nanoassembly has enhanced CD44-mediated intracellular uptake along with hyaluronidase (hylase) and redox-responsive drug-gene release. With Bcl-2 gene silencing induced by the successful delivery of HART in multidrug-resistant MCF7 breast cancer cells, the synergistic cytotoxic effect of Bcl-2 silencing and DOX was achieved. In addition, the HART nanoassembly containing GMF exhibited excellent dual MRI contrast (T1/T2) by reducing artifact signals. Overall, the HART nanoassembly with its enhanced theranostic properties has the potential to improve the therapeutic efficacy in future preclinical and clinical trials.</P> [FIG OMISSION]</BR>