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Guoli Wang,Tianyue An,Cong Lei,Xiaofeng Zhu,Li Yang,Lianxue Zhang,Ronghua Zhang 고려인삼학회 2022 Journal of Ginseng Research Vol.46 No.3
Brain-derived neurotrophic factor (BDNF)etropomyosin-related kinase B (TrkB) plays acritical role in the pathogenesis of depression by modulating synaptic structural remodeling and functional transmission. Previously, we have demonstrated that the ginsenoside Rb1 (Rb1) presents a novelantidepressant-like effect via BDNFeTrkB signaling in the hippocampus of chronic unpredictable mildstress (CUMS)-exposed mice. However, the underlying mechanism through which Rb1 counteractsstress-induced aberrant hippocampal synaptic plasticity via BDNFeTrkB signaling remains elusive. Methods: We focused on hippocampal microRNAs (miRNAs) that could directly bind to BDNF and areregulated by Rb1 to explore the possible synaptic plasticity-dependent mechanism of Rb1, which affordsprotection against CUMS-induced depression-like effects. Results: Herein, we observed that brain-specific miRNA-134 (miR-134) could directly bind to BDNF 30UTRand was markedly downregulated by Rb1 in the hippocampus of CUMS-exposed mice. Furthermore, thehippocampusetargeted miR-134 overexpression substantially blocked the antidepressant-like effects ofRb1 during behavioral tests, attenuating the effects on neuronal nuclei-immunoreactive neurons, thedensity of dendritic spines, synaptic ultrastructure, long-term potentiation, and expression of synapseassociated proteins and BDNFeTrkB signaling proteins in the hippocampus of CUMS-exposed mice. Conclusion: These data provide strong evidence that Rb1 rescued CUMS-induced depression-like effectsby modulating hippocampal synaptic plasticity via the miR-134-mediated BDNF signaling pathway.
Lingfeng Wang,Guoli Lei,Chong Yan,Hongliang Ge 한국자기학회 2019 Journal of Magnetics Vol.24 No.4
With the development of switching power supplies, miniaturization and high efficiency become hot research issues, and decreasing high-frequency losses is an effective method to achieve it. In this article, the effect of different calcination temperature on the power losses of MnZn ferrites at high frequency (500 kHz) over a broad temperature range is reported. The MnZn ferrites samples were prepared by ceramic process and the effect of calcination temperature was analyzed. The raw materials were calcined at 775 ℃, 800 ℃, 825 ℃, 850 ℃, 875℃, 900 ℃, 925 ℃ and 950 ℃, and the regular fluctuations of particle size (as-calcined), density (as-sintered) and magnetic properties are presented in this work. It is shown that the samples calcined at 850 ℃ exhibit optimal microstructure and magnetic properties. The newly developed MnZn ferrites are characterized by sintered density of 4.61 g/cm³, initial permeability of 1223 (10 kHz/0.1 mT/25 ℃), saturation magnetic flux density of 488 mT (10 kHz/1200 A/m/25 ℃) and power losses of 68 mW/cm³ (500 kHz/50 mT/100 ℃).