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Anti-collision Device for the One-Dimensional Scanning Probe Fitted to a Measuring Machine
Huihui Tian,Hongxi Wang,Guanwei Wang,Wenhong Liang 한국정밀공학회 2022 International Journal of Precision Engineering and Vol.23 No.11
The probe is at the heart of the measuring machine operation. A variety of probe types and designs are available today. However, many users continue to use the conventional one-dimensional scanning ones because of their low cost, adequate level of accuracy and performance. During the measurement process, impact phenomena between the probe ball and the part surface occur frequently due to inaccurate programming of the software and improper measurement operation, as well as the one-dimensional scanning probe is infinitely stiff in the motion direction along the machine axis, resulting in plastic deformation of the probe stylus and damage of the probe sensor. It is therefore desirable to protect the scanning probe against collision with a workpiece which is to be measured. A new anti-collision device incorporating a compliant mechanism and permanent magnets is designed in this paper. The analysis of dynamic performance for anti-collision system regarding contact force, magnetic force, velocity, position, has been performed and the maximum contact force in the event of collision is available. Numerical results and prototype experiments show the validity of the designed anti-collision device for the one-dimensional scanning probe.
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Jingyu Ni,Zhihao Liu,Miaomiao Jiang,Lan Li,Jie Deng,Xiaodan Wang,Jing Su,Yan Zhu,Feng He,Jingyuan Mao,Xiumei Gao,Guanwei Fan 고려인삼학회 2022 Journal of Ginseng Research Vol.46 No.2
Background: Ginsenoside Rg3 is one of the main active ingredients in ginseng. Here, we aimed to confirm its protective effect on the heart function in transverse aortic coarctation (TAC)-induced heart failure mice and explore the potential molecular mechanisms involved. Methods: The effects of ginsenoside Rg3 on heart and mitochondrial function were investigated by treating TAC-induced heart failure in mice. The mechanism of ginsenoside Rg3 for improving heart and mitochondrial function in mice with heart failure was predicted through integrative analysis of the proteome and plasma metabolome. Glucose uptake and myocardial insulin sensitivity were evaluated using micro-positron emission tomography. The effect of ginsenoside Rg3 on myocardial insulin sensitivity was clarified by combining in vivo animal experiments and in vitro cell experiments. Results: Treatment of TAC-induced mouse models with ginsenoside Rg3 significantly improved heart function and protected mitochondrial structure and function. Fusion of metabolomics, proteomics, and targeted metabolomics data showed that Rg3 regulated the glycolysis process, and Rg3 not only regulated glucose uptake but also improve myocardial insulin resistance. The molecular mechanism of ginsenoside Rg3 regulation of glucose metabolism was determined by exploring the interaction pathways of AMPK, insulin resistance, and glucose metabolism. The effect of ginsenoside Rg3 on the promotion of glucose uptake in IR-H9c2 cells by AMPK activation was dependent on the insulin signaling pathway. Conclusions: Ginsenoside Rg3 modulates glucose metabolism and significantly ameliorates insulin resistance through activation of the AMPK pathway.
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Guan, Wei,Liao, Haiqing,Guo, Li,Wang, Changning,Cao, Zhengguo Korean Academy of Periodontology 2016 Journal of Periodontal & Implant Science Vol.46 No.1
Purpose: Gingival recession is a major esthetic concern and may lead to root sensitivity during periodontal treatment. Coronally advanced flaps (CAFs) with and without acellular dermal matrix (ADM) are widely used in root coverage procedures. The aim of this study was to analyze the efficacy of CAF in combination with ADM in the treatment of gingival recession. Methods: PubMed, The Cochrane Library, and Embase were used to identify relevant articles. The articles were screened, data were extracted, and the quality of the studies was assessed by three reviewers with expertise in clinical practice, trials, statistics, and biomedical editing. The clinical endpoints of interest included changes in recession, probing depth (PD), clinical attachment level (CAL), and keratinized tissue (KT). Results: Ten randomized controlled trials were identified, including six studies that compared CAFs with ADM and CAFs using connective tissue grafting (CTG) and four studies that compared CAFs with or without ADM. No statistically significant differences were found between the use of ADM and CTG, whereas statistically significant differences were found between groups in which ADM and CAF were combined and groups that underwent CAF alone with regard to recession coverage, CAL, and KT. The combination of CAF with an ADM allograft achieved more favorable recession coverage and recovery of CAL and KT than CAF alone. Conclusions: The results from the ADM and CTG groups suggest that both procedures may be equally effective in clinical practice. Given the limitations of this study, further investigation is needed to clarify the effectiveness of ADM and CAF in clinical practice.
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