Multiconsensus of Second Order Multiagent Systems with Directed Topologies

Guang-Song Han,Zhi-Hong Guan,Xin-Ming Cheng,Yonghong Wu,Feng Liu 제어·로봇·시스템학회 2013 International Journal of Control, Automation, and Vol.11 No.6

A novel multiconsensus problem is introduced in multiagent systems. The states of multiple agents in each subnetwork asymptotically converge to a consistent value with information exchanges among subnetworks. The multiconsensus problem of second order multiagent systems with directed topologies is studied. Three linear protocols are proposed to solve the multiconsensus problem. Necessary and sufficient conditions are derived based on matrix theory. Simulations are provided to demonstrate the effectiveness of the theoretical results.

Hyaline Cartilage Regeneration Using Mixed Human Chondrocytes and Transforming Growth Factor-β₁- Producing Chondrocytes

Song, Sun U.,Cha, Young-Deog,Han, Jeoung-Uk,Oh, In-Suk,Choi, Kyoung Baek,Yi, Youngsuk,Hyun, Jong-Pil,Lee, Hyeon-Youl,Chi, Guang Fan,Lim, Chae-Lyul,Ganjei, J. Kelly,Noh, Moon-Jong,Kim, Seong-Jin,Lee, D Mary Ann Liebert, Inc 2005 Tissue engineering Vol.11 No.9-10

<P>The purpose of this study was to investigate the efficacy of cartilage regeneration when using a mixture of transforming growth factor-beta1 (TGF-beta1)-producing human chondrocytes (hChon-TGF-beta1) and primary human chondrocytes (hChon) ('mixed cells'), compared with either hChon-TGF-beta1 or hChon cells alone. Specifically, mixed cells or hChon cells were first injected intradermally into the backs of immune-deficient nude mice to test the feasibility of cartilage formation in vivo. Both the mixed cells and the hChon-TGF-beta1 cells alone induced cartilage formation in nude mice, whereas hChon cells alone did not. To further test the efficacy of the cells in generating cartilage, an artificially induced partial thickness defect of the femoral condyle of a rabbit knee joint was loaded with hChon-TGF-beta1 cells with or without mixing additional untransduced hChon cells, and hyaline cartilage regeneration was observed at 4 or 6 weeks. The efficiency of complete filling of the defect and the quality of tissue generated after implanting were evaluated on the basis of a histological grading system modified from O'Driscoll et al. (J. Bone Joint Surg. 70A, 595, 1988). Significantly, mixed cells (14.2 +/- 0.9) produced significantly better results than hChon-TGF-beta1 (9.0 +/- 1.7) or hChon (8.0 +/- 1.8) cells alone. Histological and immunohistochemical staining of the newly repaired tissues produced after treatment with either mixed cells or hChon-TGF-beta1 cells alone showed hyaline cartilage- like characteristics. These results suggest that the implantation of mixed cells may be a clinically efficient method of regenerating hyaline articular cartilage.</P>

Nomogram for predicting overall survival in children with neuroblastoma based on SEER database

Song-Wu Liang,Gang Chen,Yi-Ge Luo,Peng Chen,Jin-Han Gu,Qiong-Qian Xu,Yi-Wu Dang,Li-Ting Qin,Hui-Ping Lu,Wen-Ting Huang,Zhi-Guang Huang,Li Gao,Jia-Bo Chen 대한외과학회 2020 Annals of Surgical Treatment and Research(ASRT) Vol.99 No.2

Purpose: This study was performed to establish and validate a nomogram for predicting the overall survival in children with neuroblastoma. Methods: The latest clinical data of neuroblastoma in Surveillance, Epidemiology, and End Results (SEER) database was extracted from 2000 to 2016. The cases included were randomly divided into training and validation cohorts. The survival curves were drawn with a Kaplan-Meier estimator to investigate the influences of certain single factors on overall survival. Also, least absolute shrinkage and selection operator regression was applied to further select the prognostic variables for neuroblastoma. Additionally, receiver operating characteristic (ROC) curves and calibration curves were used to evaluate the accuracy of the nomogram. Results: In total, 1,262 patients were collected and 8 independent prognostic factors were achieved, including patients’ age, sex, race, tumor grade, radiotherapy, chemotherapy, tumor site, and tumor size. Then we constructed a nomogram by using the data of the training cohort with 886 cases. Subsequently, the nomogram was validated internally and externally with 886 and 376 cases, respectively. The internal validation revealed that the area under the curves (AUC) of ROC curves of 1-, 3-, and 5-year overall survival were 0.69, 0.78, and 0.81, respectively. Accordingly, the external validation also showed that the AUC of 1-, 3-, and 5-year overall survival were all ≥0.69. Both methods of validation demonstrated that the predictive calibration curves were consistent with standard curves. Conclusion: The nomogram possess the potential to be a new tool in predicting the survival rate of neuroblastoma patients.

The effect of the oxidation conditions on the surface microdomains of ZrB2-YAG ultra-high temperature ceramics

Jie-Guang Song,Min-Han Xu,Da-Ming Du,Fang Wang,Shi-Bin Li,Gang-Chang Ji 한양대학교 세라믹연구소 2013 Journal of Ceramic Processing Research Vol.14 No.4

Zirconium diboride is widely applied because of some excellent properties. The effect of the oxidation temperature on the surface microdomain of ZrB2-YAG multi-phase ceramics was studied, it helps to improve the performance of ultra-hightemperature ceramics. The results show the oxidation layer thickness is increased with an increase in the oxidation temperature, the oxidation layer thickness is decreased by increasing the density of multi-phase ceramics at the same oxidation temperature. The ceramic surface shows the (m)ZrO2, YAG, B2O3 and ZrB2 phases below the the oxidation temperature at 1300 ο C, but the ceramic surface do not show the ZrB2 phase above the oxidation temperature at 1300 ο C that is to say, the ZrB2 phase of the ceramic suface is entirely oxidized. The oxidation layer thickness is increased with an increase in the oxidation time, however, the ratio of increasing thickness is less and less. The oxidation layer shows a loose structure during the initial stage of the oxidation, which lacks a barriers for the diffusion of the oxygen.

The effect of a reinforcement phase on the oxidation mechanism of ZrB2-YAG-Al2O3 ceramcis

Jie-Guang Song,Fang Wang,Ming-Han Xu,Shi-Bin Li,Gang-Chang Ji 한양대학교 세라믹연구소 2012 Journal of Ceramic Processing Research Vol.13 No.3

ZrB2 and YAG are widely applied because of some excellent properties, but ZrB2 is easily oxidized in high-temperature air. To make ZrB2 ceramics have a better oxidation resistance, high-density ZrB2-YAG-Al2O3 ceramics were prepared. The effect of a reinforcement phase on the oxidation mechanism of ZrB2-YAG-Al2O3 ceramics is investigated at different high temperature ranges. The results show that the overall tendency of the weight gain of ZrB2-YAG ceramics and ZrB2 ceramics are similar, but the weight gain of ZrB2-YAG ceramics is less than that of ZrB2 ceramics. The weight gain tendency of three types of ceramics are similar below 1000, the weight gain of ZrB2-YAG and ZrB2-YAG-Al2O3 ceramics have a mild tendency between 1000 and 1300, the weight gain tendency of ZrB2-YAG ceramics and ZrB2 ceramics are similar at 1300, however, the weight gain tendency of ZrB2-YAG-Al2O3 ceramics became mild at 1300 due to the Al18B4O33 coating on the ceramic surface. The weight gain rapidly increased for 1h, then the weight gain tendency became mild after 1 h. The weight gain tendency of ZrB2-YAG-Al2O3 ceramics is similar by contrast with ZrB2-YAG ceramics and ZrB2 ceramics for 1 h, the weight gain tendency of ZrB2-YAG-Al2O3 ceramics is extremely mild at a higher oxidation temperature after 1 h. ZrB2 and YAG are widely applied because of some excellent properties, but ZrB2 is easily oxidized in high-temperature air. To make ZrB2 ceramics have a better oxidation resistance, high-density ZrB2-YAG-Al2O3 ceramics were prepared. The effect of a reinforcement phase on the oxidation mechanism of ZrB2-YAG-Al2O3 ceramics is investigated at different high temperature ranges. The results show that the overall tendency of the weight gain of ZrB2-YAG ceramics and ZrB2 ceramics are similar, but the weight gain of ZrB2-YAG ceramics is less than that of ZrB2 ceramics. The weight gain tendency of three types of ceramics are similar below 1000, the weight gain of ZrB2-YAG and ZrB2-YAG-Al2O3 ceramics have a mild tendency between 1000 and 1300, the weight gain tendency of ZrB2-YAG ceramics and ZrB2 ceramics are similar at 1300, however, the weight gain tendency of ZrB2-YAG-Al2O3 ceramics became mild at 1300 due to the Al18B4O33 coating on the ceramic surface. The weight gain rapidly increased for 1h, then the weight gain tendency became mild after 1 h. The weight gain tendency of ZrB2-YAG-Al2O3 ceramics is similar by contrast with ZrB2-YAG ceramics and ZrB2 ceramics for 1 h, the weight gain tendency of ZrB2-YAG-Al2O3 ceramics is extremely mild at a higher oxidation temperature after 1 h.

A novel panel of serum miR-21/miR-155/miR-365 as a potential diagnostic biomarker for breast cancer

Ji-Guang Han,Yong-Dong Jiang,Chun-Hui Zhang,Yan-Mei Yang,Da Pang,Yan-Ni Song,Guo-Qiang Zhang 대한외과학회 2017 Annals of Surgical Treatment and Research(ASRT) Vol.92 No.2

Purpose: Insufficient sensitivity and specificity prevent the use of most existing biomarkers for early detection of breast cancer. Recently, it was reported that serum microRNAs (miRNAs) may be potential biomarkers in many cancer diseases. In this study, we investigated whether serum levels of 5 miRNAs including miR-21, miR-125b, miR-145, miR-155, and miR-365 could discriminate breast cancer patients and healthy controls. Methods: Serum levels of miRNAs were measured by using quantitative real-time polymerase chain reaction in 99 breast cancer patients and 21 healthy controls. The abundance change of serum miRNAs were also evaluated following surgical resection in 20 breast cancer patients. Receiver operating characteristic (ROC) curve analysis was performed to assess the sensitivity and specificity of miRNAs as diagnostic biomarkers. Results: Serum levels of miR-21 and miR-155 was significantly higher, while miR-365 was significantly lower in breast cancer as compared with healthy controls. The serum levels of miR-21 and miR-155 significantly decreased following surgical resection. Additionally, the serum level of miR-155 at stages I and II was significantly higher compared to stage III. The serum miR-145 level was remarkably higher in progesterone receptor (PR)-positive patients than PR-negative. The positivity of miR-21, miR-155, and miR-365 was high compared to CA 153 and CEA in breast cancer. ROC curve analyses of a combination of miR-21, miR-155, and miR-365 yielded much higher area under curve and enhanced sensitivity and specificity in comparison to each miRNA alone. Conclusion: The combination of serum miR-21/miR-155/miR-365 may potentially serve as a sensitive and specific biomarker that enables differentiation of breast cancer from healthy controls.

Inhibitory Effects of <i>Houttuynia cordata</i> Water Extracts on Anaphylactic Reaction and Mast Cell Activation

Li, Guang Zhao,Chai, Ok Hee,Lee, Moo Sam,Han, Eui-Hyeog,Kim, Hyoung Tae,Song, Chang Ho Pharmaceutical Society of Japan 2005 Biological & pharmaceutical bulletin Vol.28 No.10

<P>The present study was investigated the effect of <I>Houttuynia cordata</I> T<SMALL>HUNB</SMALL> water extract (HCWE) on mast cell-mediated anaphylactic reactions. The mast cell-mediated anaphylactic reaction is involved in many allergic diseases such as asthma and allergic rhinitis. HCWE has been used as a traditional medicine in Korea and is known to have an antioxidant and anti-cancer activities. However, its specific effect of mast cell-mediated anaphylactic reactions is still unknown. We examined whether HCWE could inhibit compound 48/80-induced systemic anaphylaxis, IgE-mediated passive cutaneous anaphylaxis (PCA), and mast cell activation. The oral administration of HCWE inhibited compound 48/80-induced systemic anaphylaxis in mice. HCWE also inhibited the local allergic reaction, PCA, activated by anti-dinitrophenyl (DNP) IgE antibody in rats. HCWE reduced the compound 48/80-induced mast cell degranulation and colchicine-induced deformation of rat peritoneal mast cells (RPMC). Moreover, HCWE dose-dependently inhibited histamine release and calcium uptake of RPMC induced by compound 48/80 or anti-DNP IgE. HCWE increased the level of intracellular cAMP and inhibited significantly the compound 48/80-induced cAMP reduction in RPMC. These results suggest that HCWE may be beneficial in the treatment of mast cell-mediated anaphylactic responses.</P>

Effect of the sintering technology on the properties of fired brick from quartz sands

Jie-Guang Song,Fang Wang,Xiao-Bo Bai,Da-Ming Du,Yin-Yan Ju,Ming-Han Xu,Gang-Chang Ji 한양대학교 세라믹연구소 2011 Journal of Ceramic Processing Research Vol.12 No.4

River sands as low grade natural raw materials are used to prepare the fired brick to replace clay fired bricks, which aims to save land resources and use low grade natural resources to realize high cost performance. In this paper, the effect of sintering technology of bricks on their performance is discussed. The compressive strength of fired bricks is first increased and then decreased with an increase in the sintering temperature, the compressive strength of bricks prepared by the isostatic compaction shaping is higher than that of bricks prepared by the plastic shaping under the same conditions. The compressive strength of bricks reaches 28 MPa when sintered at 1150 oC by using a 20MPa isostatic compaction shaping method. The compressive strength of bricks is first increased and then decreased by prolonging the holding time, the compressive strength of bricks reaches 28.9MPa when sintered at 1150 oC for 2 h.

Effect of synthesis conditions on the particle size and morphology of YAG powder

Jie-Guang Song,Fang Wang,Ming-Han Xu,Yin-Yan Ju,Yang-Liang Li,Shi-Bin Li,Gang-Chang Ji 한양대학교 세라믹연구소 2012 Journal of Ceramic Processing Research Vol.13 No.2

Yttrium aluminum garnet (YAG) is currently a widely applied structural and functional material. To prepare highperformance YAG ceramics we prepared pure YAG powder, after calcining the precursor at 1100 ºC, by co-precipitation with ammonia as the precipitant and aluminum nitrate as well as yttrium nitrate as raw materials. The preparation conditions for the YAG precursor were a pH of 9, a titration rate of 10 ml/ minute and a reaction time of 60 minutes. The mean paricle size of the YAG powder was 11ìm. The mean particle size for the YAG powder increased with an increase in the pH and at a higher pH the YAG particles were more irregular in shape. The mean particle size and particle size distribution range of the YAG powder increased with an increase in the titration rate. For the YAG powder with a higher mean particle size, the particle size distribution range was wider but the size of most YAG particles was still small and the YAG particles were nearly spherical.

Chalcones from the Flowers of Rosa Rugosa and Their Anti-tobacco Mosaic Virus Activities

Du, Gang,Han, Jing-Mei,Kong, Wei-Song,Zhao, Wei,Yang, Hai-Ying,Yang, Guang-Yu,Gao, Xue-Mei,Hu, Qiu-Fen Korean Chemical Society 2013 Bulletin of the Korean Chemical Society Vol.34 No.4