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Improving the Performance of OFDM-Based Vehicular Systems through Diversity Coding
Arrobo, Gabriel E.,Gitlin, Richard D. The Korea Institute of Information and Commucation 2013 Journal of communications and networks Vol.15 No.2
In this paper, we present diversity coded orthogonal frequency division multiplexing (DC-OFDM), an approach to maximize the probability of successful reception and increase the reliability of OFDM-based systems through diversity coding. We focus on the application of DC-OFDM to vehicular networks based on IEEE 802.11p technology and analyze the performance improvement using this new technology. It is shown that DC-OFDM significantly improves the performance of vehicular ad hoc networks in terms of throughput and the expected number of correctly received symbols.
L-Asparaginase encapsulated intact erythrocytes for treatment of acute lymphoblastic leukemia (ALL)
Kwon, Y.M.,Chung, H.S.,Moon, C.,Yockman, J.,Park, Y.J.,Gitlin, S.D.,David, A.E.,Yang, V.C. Elsevier Science Publishers 2009 Journal of controlled release Vol.139 No.3
As a primary drug for the treatment of acute lymphoblastic leukemia (ALL), encapsulation of L-asparaginase (ASNase) into red blood cells (RBC) has been popular to circumvent immunogenicity from the exogenous protein. Unlike existing methods that perturbs RBC membranes, we introduce a novel method of RBC-incorporation of proteins using the membrane-translocating low molecular weight protamine (LMWP). Confocal study of fluorescence-labeled LMWP-ovalbumin, as a model protein conjugate, has shown significant fluorescence inside RBCs. Surface morphology by scanning electron microscopy of the RBCs loaded with LMWP-ASNase was indistinguishable with normal RBCs. These drug loaded RBCs also closely resembled the profile of the native erythrocytes in terms of osmotic fragility, oxygen dissociation and hematological parameters. The in vivo half-life of enzyme activity after administering 8 units of RBC/LMWP-ASNase in DBA/2 mice was prolonged to 4.5+/-0.5 days whereas that of RBCs loaded with ASNase via a hypotonic method was 2.4+/-0.7 days. Furthermore, the mean survival time of DBA/2 mice bearing mouse lymphoma cell L5178Y was improved by ∼44% compared to the saline control group after treatment with the RBC loaded enzymes. From these data, an innovative, novel method for encapsulating proteins into intact and fully functional erythrocytes was established for potential treatment of ALL.