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RISS 인기검색어
- 검색키워드
- 저자 : Gasser, J. (검색결과 17 건)
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T. Christian Gasser 한국계산역학회 2007 Computers and Concrete, An International Journal Vol.4 No.1
The discrete crack-concept is applied to study the 3D propagation of tensile-dominated failure in plain concrete. To this end the Partition of Unity Finite Element Method (PUFEM) is utilized and the strong discontinuity approach is followed. A consistent linearized implementation of the PUFEM is combined with a predictor-corrector algorithm to track the crack path, which leads to a robust numerical description of concrete cracking. The proposed concept is applied to study concrete failure during the PCT3D test and the predicted numerical results are compared to experimental data. The proposed numerical concept provides a clear interface for constitutive models and allows an investigation of their impact on concrete cracking under 3D conditions, which is of significant scientific interests to interpret results from 3D experiments.
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CCL2 Chemokine as a Potential Biomarker for Prostate Cancer: A Pilot Study
Igor Tsaur,Anika Noack,Jasmina Makarevic,Elsie Oppermann,Ana Maria Waaga-Gasser,Martin Gasser,Hendrik Borgmann,Tanja Huesch,Kilian M. Gust,Michael Reiter,David Schilling,Georg Bartsch,Axel Haferkamp,R 대한암학회 2015 Cancer Research and Treatment Vol.47 No.2
Purpose Prostate specific antigen is not reliable in diagnosing prostate cancer (PCa), making theidentification of novel, precise diagnostic biomarkers important. Since chemokines areassociated with more aggressive disease and poor prognosis in diverse malignancies, weaimed to investigate the diagnostic relevance of chemokines in PCa. Materials and MethodsPreoperative and early postoperative serum samples were obtained from 39 consecutivePCa patients undergoing radical prostatectomy. Serum from 15 healthy volunteers servedas controls. Concentrations of CXCL12, CXCL13, CX3CL1, CCL2, CCL5, and CCL20 weremeasured in serum by Luminex. The expression activity of CXCR3, CXCR4, CXCR5, CXCR7,CXCL12, CXCL13, CX3CR1, CXCL1, CCR2, CCR5, CCR6, CCR7, CCL2, and CCL5 mRNA wasassessed in tumor and adjacent normal tissue of prostatectomy specimens by quantitativereal-time polymerase chain reaction. The associations of these chemokines with clinicaland histological parameters were tested. ResultsThe gene expression activity of CCL2 and CCR6 was significantly higher in tumor tissuecompared to adjacent normal tissue. CCL2 was also significantly higher in the blood samplesof PCa patients, compared to controls. CCL5, CCL20, and CX3CL1 were lower in patientserum, compared to controls. CCR2 tissue mRNA was negatively correlated with the Gleasonscore and grading. ConclusionChemokines are significantly modified during tumorigenesis of PCa, and CCL2 is a promisingdiagnostic biomarker.
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Learning Morphophonemic Processes without Underlying Representations and Explicit Rules
Lee, Chan-Do,Michael Gasser 서울대학교 어학연구소 1991 語學硏究 Vol.27 No.2
Traditional phonology presupposes abstract underlying representations (UR) and a set of rules to explain the phonological phenomena. There are, however, a number of questions that have been raised regarding this approach : Where do URs come from? How are rules found and related to each other? In the current study, a connectionist network was trained without the benefit of any UR and explicit rules. We hypothesized that rules would emerge as the generalizations the network abstracts in the process of learning to associate forms (sequences of phonological segments comprising words) with meanings (of the words) and URs as a pattern on the hidden layer. Employing a simple recurrent network we ran a series of simulations on different types of morphophonemic processes. The results of the simulations show that this network is capable of learning morphophonemic processes without any URs and explicit rules.
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Manning, A.,Highland, H. M.,Gasser, J.,Sim, X.,Tukiainen, T.,Fontanillas, P. AMERICAN DIABETES ASSOCIATION INC 2017 Diabetes Vol.66 No.7
<P>To identify novel coding association signals and facilitate characterization of mechanisms influencing glycemic traits and type 2 diabetes risk, we analyzed 109,215 variants derived from exome array genotyping together with an additional 390,225 variants from exome sequence in up to 39,339 normoglycemic individuals from five ancestry groups. We identified a novel association between the coding variant (p.Pro50Thr) in AKT2 and fasting plasma insulin (FI), a gene in which rare fully penetrant mutations are causal for monogenic glycemic disorders. The low-frequency allele is associated with a 12% increase in FI levels. This variant is present at 1.1% frequency in Finns but virtually absent in individuals from other ancestries. Carriers of the FI-increasing allele had increased 2-h insulin values, decreased insulin sensitivity, and increased risk of type 2 diabetes (odds ratio 1.05). In cellular studies, the AKT2-Thr50 protein exhibited a partial loss of function. We extend the allelic spectrum for coding variants in AKT2 associated with disorders of glucose homeostasis and demonstrate bidirectional effects of variants within the pleckstrin homology domain of AKT2.</P>
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