현대와 전통의 교착(交錯)과 융합 : 漫說: 조선족 작곡가 權吉浩의 음악창작

가오, 웨이 지 漢陽大學校 音樂硏究所 1993 音樂論壇 Vol.7 No.-

7년 전, 내가 제4차 전국음악작품 콩쿨 평심위원으로 있었을 때, 처음으로 조선족 청년작곡가 권길호(권길호)의 작품을 듣게 되었다. 그때 상해음악학원의 이름없는 작곡과 학생이었던 권길호가 보내온 작품은 피아노 조곡 「장단의 조합」이었다. 「장단의 조합」,(중국인들에겐 "장단"이란 단어가 길고 짧음으로 밖에 이해되지 않는다-번역자)이 괴상한 표제의 곡을 받아 보면서 처음엔 모두들 "선봉파"식의 추상적인 작품이 아닌가고 생각하였다. 사실 이 작품은 농후한 조선족 음악쟝르와 민속적인 정감이 차 넘친 아름다운 곡이었다. 그 당시 이 작품은 청년 피아노연주가 리건의 현장연주 후 강렬한 반응을 일으켰는데, 전체 평심위원들과 관람자들을 번쩍 놀래웠다고 보도되었다. 하여 이 작품은 그번 콩클에서 제일 첫자리로 수석 1등상을 타게 되었고, 그때로부터 권길호(권길호)라는 이 이름을 기억하게 되었다.

Dynamic simulation and control of a triple column process for dimethyl carbonate- methanol separation

Hong-Mei Wei,Qiang Gao,Wei-zhou Jiao,Wei Wei 한국화학공학회 2022 Korean Journal of Chemical Engineering Vol.39 No.12

Separation of dimethyl carbonate/methanol azeotropic mixture by using pressure-swing distillation processhas been a hot-point in the study of the synthesis process of dimethyl carbonate by urea methanolysis method. Thisstudy updates the work of the writers (Ind.Eng.Chem.Res,2013,52,11463-11478), which explores the dynamic controlstructure of the three-column separation dimethyl carbonate (DMC)/methanol (MeOH) process from an actual pilotplant. At first, the conventional DMC/MeOH separation process in the pilot test of the DMC synthesis process throughalcoholysis of urea was described in detail. Then an optimized control structure for the entire DMC/MeOH separationunit was obtained by implementing a general heuristic design procedure. An economic analysis was performed to evaluatethe optimized process. Finally, three dynamic control schemes were proposed and evaluated with several large disturbances,an improved control scheme CS3, using the multiplier blocks “QR1/F1” and “RR1” in T1, “QR1/F1” and “R/F”in both T2 and T3, outperformed CS1 and CS2 by maintaining the product specification in each column.

Metabolomes and transcriptomes revealed the saponin distribution in root tissues of Panax quinquefolius and Panax notoginseng

Wei, Guangfei,Yang, Feng,Wei, Fugang,Zhang, Lianjuan,Gao, Ying,Qian, Jun,Chen, Zhongjian,Jia, Zhengwei,Wang, Yong,Su, He,Dong, Linlin,Xu, Jiang,Chen, Shilin The Korean Society of Ginseng 2020 Journal of Ginseng Research Vol.44 No.6

Background: Panax quinquefolius and Panax notoginseng are widely used and well known for their pharmacological effects. As main pharmacological components, saponins have different distribution patterns in the root tissues of Panax plants. Methods: In this study, the representative ginsenosides were detected and quantified by desorption electrospray ionization mass spectrometry and high-performance liquid chromatography analysis to demonstrate saponin distribution in the root tissues of P. quinquefolius and P. notoginseng, and saponin metabolite profiles were analyzed by metabolomes to obtain the biomarkers of different root tissues. Finally, the transcriptome analysis was performed to demonstrate the molecular mechanisms of saponin distribution by gene profiles. Results: There was saponin distribution in the root tissues differed between P. quinquefolius and P. notoginseng. Eight-eight and 24 potential biomarkers were detected by metabolome analysis, and a total of 340 and 122 transcripts involved in saponin synthesis that were positively correlated with the saponin contents (R > 0.6, P < 0.05) in the root tissues of P. quinquefolius and P. notoginseng, respectively. Among them, GDPS1, CYP51, CYP64, and UGT11 were significantly correlated with the contents of Rg1, Re, Rc, Rb2, and Rd in P. quinquefolius. UGT255 was markedly related to the content of R1; CYP74, CYP89, CYP100, CYP103, CYP109, and UGT190 were markedly correlated with the Rd content in P. notoginseng.

Clinicopathologic and Prognostic Significance of the Zinc Finger of the Cerebellum Family in Invasive Breast Cancer

Wei Han,Cong Zhang,Xiao-jiao Gao,Hua-bing Wang,Fang Chen,Fang Cao,Yong-wei Hu,Jun Ma,Xing Gu,Hou-zhong Ding 한국유방암학회 2018 Journal of breast cancer Vol.21 No.1

Purpose: Five members of the zinc finger of the cerebellum (ZIC) family—ZIC1, ZIC2, ZIC3, ZIC4, and ZIC5—have been shown to be involved in various carcinomas. Here, we aimed to explore the clinicopathologic and prognostic roles of ZIC family members in invasive breast cancer patients using immunohistochemical analysis, western blotting analysis, and real-time quantitative polymerase chain reaction (RT-qPCR). Methods: A total of 241 female invasive breast cancer patients who underwent radical mastectomy between 2009 and 2011 were enrolled. ZIC proteins in 241 pairs of breast tumors and corresponding normal tissues were investigated using immunohistochemistry and the clinicopathologic roles of proteins were analyzed using Pearson’s chi-square test. Kaplan-Meier curves and Cox regression analysis were also used to analyze the prognostic value of the ZIC proteins. In addition, 12 pairs of fresh-frozen breast tumors and matched normal tissues were used in the western blotting analysis and RT-qPCR. Results: Only ZIC1 expression in normal tissues was obviously higher than that in tumors (p<0.001). On multivariate analysis, ZIC1 expression (in overall survival analysis: hazard ratio [HR], 0.405, 95% confidence interval [CI], 0.233–0.702, p=0.001; in disease-free survival analysis: HR, 0.395, 95% CI, 0.234–0.669, p=0.001) was identified as a prognostic indicator of invasive breast cancer. Conclusion: ZIC1, but not the other proteins, was obviously decreased in breast tumors and associated with clinicopathologic factors. Thus, ZIC1 might be a novel indicator to predict the overall and disease-free survival of invasive breast cancer patients.

Biomimetic Surface Modification of Polycarbonateurethane Film via Phosphorylcholine-Graft for Resisting Platelet Adhesion

Wei Gao,Jintang Guo,Yakai Feng,Jian Lu,Musammir Khan 한국고분자학회 2012 Macromolecular Research Vol.20 No.10

Phosphorylcholine groups were covalently introduced onto a polycarbonateurethane (PCU) surface in order to create a biomimetic structure on the polymer surfaces. After introducing primary amine groups onto the polymer surface by 1,6-hexanediamine, phosphorylcholine groups were covalently linked onto the surface by the reductive amination between the amino group and the aldehyde group of phosphorylcholine glyceraldehyde (PCGA). The results of water contact angle test, X-ray photoelectron spectroscopy (XPS), and X-ray fluorescence spectrometer (XRF) analysis of the modified films indicated that PCGA had already been covalently linked to the PCU surface. The topographies and surface roughnesses were both imaged and measured by atomic force microscopy (AFM). Scanning electron microscopy (SEM)observation of the PCU films after treatment with platelet-rich plasma demonstrated that platelets had rarely adhered to the surface of the PCGA-grafted PCU films but had mainly adhered to the surface of the blank PCU films. The platelet adhesion result indicated that the PC modified PCU films could resist platelet adhesion after grafting with PCGA, and that these PCGA-grafted PCU materials, potentially, might be applied as blood-contacting materials.

TIGHT TOUGHNESS CONDITION FOR FRACTIONAL (g, f, n)-CRITICAL GRAPHS

Gao, Wei,Liang, Li,Xu, Tianwei,Zhou, Juxiang Korean Mathematical Society 2014 대한수학회지 Vol.51 No.1

A graph G is called a fractional (g, f, n)-critical graph if any n vertices are removed from G, then the resulting graph admits a fractional (g, f)-factor. In this paper, we determine the new toughness condition for fractional (g, f, n)-critical graphs. It is proved that G is fractional (g, f, n)-critical if $t(G){\geq}\frac{b^2-1+bn}{a}$. This bound is sharp in some sense. Furthermore, the best toughness condition for fractional (a, b, n)-critical graphs is given.

Statistical Optimization of Medium Components for Milk-Clotting Enzyme Production by Bacillus amyloliquefaciens D4 Using Wheat Bran-an Agro-Industry Waste

( Wei Bing Zhang ),( Xiao Ling He ),( Hong Na Liu ),( Hui Yuan Guo ),( Fa Zheng Ren ),( Wei Dong Gao ),( Peng Cheng Wen ) 한국미생물 · 생명공학회 2013 Journal of microbiology and biotechnology Vol.23 No.8

In this paper, two statistical methods were applied to optimize medium components to improve the production of the milk-clotting enzyme by Bacillus amyloliquefaciens D4. First, wheat bran juice, skim milk powder, and Na2HPO4 were shown to have significant effects on D4 enzyme production using the Plackett?Burman experimental design. Subsequently, an optimal medium was obtained using the Box?Behnken method, which consisted of 3.31 g/l of skim milk powder, 5.0 g/l of sucrose, 0.1 g/l of FeSO4?7H2O, 0.1 g/l of MgSO4?7H2O, 0.1 g/l of MnSO4?2H2O, 0.1 g/l of ZnSO4?7H2O, 1.52 g/l of Na2HPO4, and 172.45 g/l of wheat bran juice. With this optimal medium, the milk-clotting enzyme production was remarkably enhanced. The milk-clotting enzyme activity reached 3,326.7 SU/ml after incubation of 48 h, which was 1.76-fold higher than that of the basic medium, showing that the Plackett?Burman design and Box?Behnken response surface method are effective to optimize medium components, and B. amyloliquefaciens D4 possessed a high rennet-producing capacity in the optimal medium.

<i>Orobanche cernua</i> Loefling Attenuates Ultraviolet B-mediated Photoaging in Human Dermal Fibroblasts

Gao, Wei,Wang, Yu-shuai,Qu, Zheng-yi,Hwang, Eunson,Ngo, Hien T. T.,Wang, Ying-ping,Bae, Jahyun,Yi, Tae-hoo Wiley (Blackwell Publishing) 2018 Photochemistry and photobiology Vol.94 No.4

<P>UV radiation is the primary cause of skin photoaging, which results in an increase in matrix metalloproteinases and degradation of collagen. Developing new natural antioxidant as photoprotective agents has become a popular area of research. Orobanche cernua Loefling is a parasitic plant that is rich in phenylethanoid glycosides (PhGs). This study investigated the photoprotective effects of the ethanolic extract of Orobanche cernua Loefling (OC) and its principal component acteoside on UVB-induced photoaging as well as their underlying molecular mechanisms in normal human dermal fibroblasts (NHDFs). Biological testing demonstrated that OC and acteoside possessed significant photoprotective activities, reducing MMP and IL-6 levels while improving type-I procollagen synthesis in UVB-irradiated NHDFs. Further study showed that the protective mechanisms were the improvement of transcription factor Nrf2-mediated antioxidant defensive system, suppression of MAPK/AP-1 and activation of the TGF-/Smad pathway. Together, our results suggested that OC might be a promising antiphotoaging agent against UV radiation-induced skin damage.</P>

Risk Factors of Hepatocellular Carcinoma - Current Status and Perspectives

Gao, Jing,Xie, Li,Yang, Wan-Shui,Zhang, Wei,Gao, Shan,Wang, Jing,Xiang, Yong-Bing Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.3

Hepatocellular carcinoma is a common disorder worldwide which ranks 5th and 7th most common cancer among men and women. In recent years, different incidence trends have been observed in various regions, but the reasons are not completely understood. However, due to the great public efforts in HCC prevention and alternation of lifestyle, the roles of some well documented risk factors played in hepatocarcinogenesis might have changed. This paper summarizes both the environmental and host related risk factors of hepatocellular carcinoma including well established risk factors such as hepatitis virus infection, aflatoxin and alcohol, as well as possible risk factors such as coffee drinking and other dietary agents.

Precision Nanometrology and its Applications to Precision Nanosystems

Wei Gao 한국정밀공학회 2005 International Journal of Precision Engineering and Vol.6 No.4

In this paper, a new field of metrology called "precision nanometrology" is presented. The "precision nanometrology" is the result of evolutions of the traditional "precision metrology" and the new "nanometrology". "Precision nanometrology" is defined here as the science of dimensional measurement and motion measurement with 100 ㎚ to 0.1 ㎚ resolution/uncertainty within a range of micrometer to meter. The definition is based on the fact that nanometrology in nanoengineering and the precision industries, such as semiconductor industry, precision machine tool industry, precision instrument industry, is not only concerned with the measurement resolution and/or uncertainty but also the range of measurement. It should also be pointed out that most of the measurement objects in nanoengineering have dimensions larger than I micrometer. After explaining the definition of precision nanometrology, the paper provides several examples showing the critical roles of precision nanometrologv in precision nanosystems, including nanometrology system, nanofabrication system, and nanomechatronics system.