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千在植,鄭世賢 단국대학교 1994 論文集 Vol.28 No.-
Sound is the sensation produced when longitudinal variations of molecules in the external environment. ie, altenate phases of condensation and rarefaction of the molecules, strike the tympanic membrane. The purpose of speaking is communication between humans. It is very important for social life to speak and hear exactly. It there were problems to speak, it is very unconvenient for social life psychologically. The purpose of this experiment was to analyse the frequency and duration of pronunciation. Each 20 male and female who were living in Seoul and speaking standard Korean, had participated in this experiment. Each 10 male and female, who were wearing dentures and adapted at least over 1 years, had participated in this experiment also. The data were taken and analysed by Philips PM 3350A Storage Oscilloscope which had 68008 up microprocessor IEEE-488 interface. The results were as follows 1. High pitches were appeared in early stage of pronunciation in plosive sounds(ㅂ, ㅋ, ㅌ, ㅍ)and Y system vowel diphthorgs. 2. Condensation waves were seen in later stage of pronunciation in frictional sounds(ㅅ,ㅎ) and nasal sound(ㄴ, ㅁ). 3. the average data of frequency and duration were as follows ◁ 표 삽입 ▷ (원문을 참조하세요) 4. There were special pitches such as 111, 181, 200, 250, 333, 400, 500, 1000, 2000 Hz in all subjects
정상인 악골내 삽입된 I.M.Z. 매식체의 골융합에 관한 주사전자현미경적 연구
주경환,천재식,이종헌 단국대학교 치의학연구소 1993 논문집 Vol.5 No.-
The purpose of this study was to observe morphologically osseointegration and change about bone and peripheral tissue in IMZ implants on 3 and 9 month in normal human mandible. 4 IMZ implants with 3.3mm in diameter and 10mm in length were implanted in normal human mandible. For scanning electron microscopic study in 3 and 9 month, IMZs were explanted by trephine bur, washed with normal saline, fixed with 2.5% glutaraldehyde for 3 days, postifixed with 1% OsO_4, dehydrated gradually with ethyl alchol, changed with isoamyl acetate, and dried with CO_2 critical point dryer. The specimens were gold-plated and examined with scanning electronmicroscope. The obtained results were as follows. 1. There were moderately mineralized trabecular in vent of IMZ, irregular directions of collagen fibers, fibroblasts, osteocytes with prominent process surrounded by moderately mineralized bone in scanning electron microscopic study after 3month of post operation tissues. 2. Scanning electron microscopic study of 3 month showed rarely inflammatory cell infiltration among IMZ, bone tissue, and collagen fiber, disclosing many blood vessels in less mineralized osteoid containing RBCs, fibrin, and rare leukocytes. 3. Scanning electron microscopic study of 9 month showed mainly mineralized, irregular trabecular attached to vent of IMZ, and osteocytes with promint processes in lacuna surrounded by mineralized bone. 4. Scanning electronmicroscopic study of 9 month showed rarely inflammatory cell infiltration between bone and IMZ, and more decreased number of blood vessel than that of 3 month.
P2X7 Receptor-mediated Membrane Blebbing in Salivary Epithelial Cells
황성민,구나연,최세영,Gae-Sig Chun,김중수,박경표 대한약리학회 2009 The Korean Journal of Physiology & Pharmacology Vol.13 No.3
High concentrations of ATP induce membrane blebbing. However, the underlying mechanism involved in epithelial cells remains unclear. In this study, we investigated the role of the P2X7 receptor (P2X7R) in membrane blebbing using Par C5 cells. We stimulated the cells with 5 mM of ATP for 1∼2 hrs and found the characteristics of membrane blebbing, a hallmark of apoptotic cell death. In addition, 500μM Bz-ATP, a specific P2X7R agonist, induced membrane blebbing. However, 300μM of Ox-ATP, a P2X7R antagonist, inhibited ATP-induced membrane blebbing, suggesting that ATP- induced membrane blebbing is mediated by P2X7R. We found that ATP-induced membrane blebbing was mediated by ROCK I activation and MLC phosphorylation, but not by caspase-3. Five mM of ATP evoked a biphasic [Ca2+]i response; a transient [Ca2+]i peak and sustained [Ca2+]i increase secondary to ATP-stimulated Ca2+ influx. These results suggest that P2X7R plays a role in membrane blebbing of the salivary gland epithelial cells.
Capsaicinoids가 삼차신경감각핵의 신경전달물질 유리에 미치는 영향
안명석,이일규,천재식 단국대학교 치의학연구소 1994 논문집 Vol.6 No.2
Excitatory amino acids(EAA) neurotransmitters, glutamate and aspartate, play a role in transmission of primary afferents of orofacial pain in trigeminal spinal sensory nucleus. This experiment was performed to study the role of capsaicin, its derivative and analogue on release of glutamate and aspartate from trigeminal spinal sensory nucleus in slice of brainstem. Horizontal slice of caudal brainstem of rat was prepared and perfused with modified Krebs-Ringer solution in brain slice chamber. Release of EAAs was induced by capsaicin(10μM), KR-25018(10μM) and shogaol(10μM), which was added to perfusion solution to observe the changes in EAAs release and effect of ruthenium red and capsazepine on the capsaicinoids. And then EAAs being determined by HPLC. Release of glutamate and aspartate from horizontal slice of caudal brainstem was increased by capsaicin and KR-25018. But shogaol had not affected on release of EAA. Effect of capsaicin and KR-25018 was partially blocked by capsaicin antagonists, ruthenium red and capsazepine in vitro.
Diode Laser 조사가 가토경골의 골재형성에 미치는 영향에 관한 연구
강봉기(Bong Ki Kang),천재식(Gae Sig Chun) 대한구강악안면병리학회 2010 대한구강악안면병리학회지 Vol.34 No.6
Currently, Low-level laser therapy (LLLT) is widely used in medicine and dentistry. It has been suggested that LLLT may be beneficial in management of many different medical conditions, including pain, wound healing and nerve injury. Stimulation with LLLT can enhance bone repair as reported in experimental studies on bone defects and fracture healing also. As far as hard tissue is concerned, the biostimulating effect of laser has been demonstrated more rapid healing of tibial bone fracture in mice. This study was performed to compare new bone formation between with LLLT and without LLLT. Two cylinder implants(5mm diameter, 5mm length) were implanted on rabbit's tibia. LLLT was done to one implant with 632mm diode laser. And than Rabbit's were sacrificed after 2nd, 4th, 6th, 8th weeks after implantation. Bone with implant were removed and fixed with 10% formaline. Undecalfied sample were prepared after spurr low resin embedding. Sample were grind and polished to 100㎛. The results were as follows. The amount of trabeclue of experimental group were superior to that of control group from 2 weeks to 8 weeks. There were no difference in arrangement of trabecule between two groups. Bone implant contact were significantly increased at 4th weeks in experimental group. The number of ostecytes in trabecule were different at 4th weeks experimental group. Osteone were appeared dominantly at 6th weeks experimental group, while at 8th weeks experimental group were superior than control group. LLLT group showed increased amount of trabecule, bone implant contact, number of osteocytes & osteone. It suggested that LLLT might be increase the bone formation rate and accelerate the bone formation time.