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- 저자 : Fengshan Zhang (검색결과 6 건)
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Chengshuo Zhang,Dazhi Fu,Fengshan Wang,Xinping Zhong,Lei Yang,Gang Wu,Baifeng Li,Jialin Zhang 대한외과학회 2021 Annals of Surgical Treatment and Research(ASRT) Vol.100 No.4
Purpose: Oxidized cellulose is available in many forms, but manufactured using either a regenerated or non-regenerated process. In this study, we evaluated the effects of 2 different hemostatic agents for the treatment of local bleeding in patients undergoing hepatic resection. Methods: This was a monocentric, parallel-group, randomized, and controlled clinical trial to compare oxidized regenerated cellulose gauze (ORCG) with oxidized non-regenerated cellulose gauze (ONRCG) in patients undergoing hepatectomy. The primary endpoint was the time to hemostasis at the target bleeding site. The secondary endpoints were the postoperative drainage volume on the first 2 days after surgery and the hospital stay. Results: There was no significant difference between the ORCG and ONRCG groups in time to hemostasis from column analysis (238.8 ± 121.6 seconds vs. 193.7 ± 85.3 seconds, P = 0.068), and there were no differences in the rates of hemostatic success between the 2 groups at 120 seconds (18.4% vs. 24.3%; odds ratio [OR], 0.703; 95% confidence interval [CI], 0.231–2.136) and 300 seconds (71.1% vs. 89.2%; OR, 0.298; 95% CI, 0.085–1.041). However, the ONRCG group was superior to the ORCG group in hemostasis according to the survival analysis (log-rank test, P = 0.044). Moreover, there were also no significant differences between the 2 groups in postoperative drainage volume on the first 2 days (P = 0.436, P = 0.381) and hospital stay (P = 0.537, P = 0.200). Conclusion: ONRCG was not inferior to ORCG as a hemostatic agent in patients undergoing liver resection.
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SPA Model on Repair Priority for Earthquake-damaged Transport Infrastructures
Fengshan Wang,Hongjun Zhang,Wanhong Zhu 보안공학연구지원센터 2016 International Journal of Database Theory and Appli Vol.9 No.9
Sequence is an important mission and performance in such repair decision-making operation for the earthquake-damaged transport infrastructures. Through introducing Set Pair Analysis ideology, the decision-making model was established for earthquake repair sequence of transport infrastructures. Then, the SPA comparing space was built, the association identity, contrary and difference degree parameters were calculated for repair projects, the relative SPA proximity was determined for each repair project, as well as the repair sequence was given. Meanwhile, the integration of Efficiency Coefficient method and Information Entropy to determine the index weights, improved the reliability of repair sequence. Finally, Case showed a typical evaluation index system and model application, which provided a scientific, simple and suitable method on the repair priority decision-making operation for the earthquake-damaged transport infrastructures.
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Gao, Demin,Zhang, Xulong,Zhang, Jian,Cao, Jichao,Wang, Fengshan 대한약학회 2008 Archives of Pharmacal Research Vol.31 No.11
Thymopentin plays an important role in improving imbalanced immune systems of patients, however, it has a limited half-life in plasma. To get more stable and active thymopentin analogs, a fusion thymosin ${\alpha}1$-thymopentin ($T{\alpha}1$-TP5) gene was synthesized and cloned into vector $pGAPZ{\alpha}A$. $T{\alpha}1$-TP5 fusion peptide was expressed in pichia pastoris and purified by metal chelating chromatography and gel filtration chromatography. The circular dichroism spectra (CD) indicated that the secondary structure of $T{\alpha}1$-TP5 fusion peptide is dominated by a-helix and random coil. In vitro analysis showed that the plasma half-life of $T{\alpha}1$-TP5 fusion peptide is $140{\pm}14\;min$, which is longer than that of TP5 ($5.6{\pm}0.7\;min$) and $T{\alpha}1$ ($127{\pm}11\;min$). The in vitro activity assay presented that $T{\alpha}1$-TP5 fusion peptide has greater activity in promoting proliferation of Kunming mouse splenocytes, and in vivo experiment it showed better activity in promoting the phagocytosis of macrophages and secretion of IL-2 than both $T{\alpha}1$ and TP5. Our findings suggest that $T{\alpha}1$-TP5 fusion peptide might be a potential therapeutic agent.
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Expression of Thymosin α1-thymopentin Fusion Peptide in Pichia pastoris and its Characterization
Demin Gao,Xulong Zhang,Jian Zhang,Jichao Cao,Fengshan Wang 대한약학회 2008 Archives of Pharmacal Research Vol.31 No.11
Thymopentin plays an important role in improving imbalanced immune systems of patients, however, it has a limited half-life in plasma. To get more stable and active thymopentin analogs, a fusion thymosin α1-thymopentin (Tα1-TP5) gene was synthesized and cloned into vector pGAPZαA. Tα1-TP5 fusion peptide was expressed in pichia pastoris and purified by metal chelating chromatography and gel filtration chromatography. The circular dichroism spectra (CD) indicated that the secondary structure of Tα1-TP5 fusion peptide is dominated by a-helix and random coil. In vitro analysis showed that the plasma half-life of Tα1-TP5 fusion peptide is 140 ±14 min, which is longer than that of TP5 (5.6±0.7 min) and Tα1 (127±11 min). The in vitro activity assay presented that Tα1-TP5 fusion peptide has greater activity in promoting proliferation of Kunming mouse splenocytes, and in vivo experiment it showed better activity in promoting the phagocytosis of macrophages and secretion of IL-2 than both Tα1 and TP5. Our findings suggest that Tα1-TP5 fusion peptide might be a potential therapeutic agent.
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Qiuyue Du,Song Chen,Shuo Cheng,Fengshan Du,Liang Li,Quantong Li,Limei Zhang 대한기계학회 2022 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.36 No.6
The integrated electric wheel module (IEWM) with large-angle steering capability is blooming which greatly alters the conventional chassis structure over recent years. The IEWM brings challenges to the suspension system due to higher requirements, which includes 360 degrees steering, active adjustment of chassis height and posture, superior ride comfort, and compact mechanical structure. Hence, a novel double trailing arm suspension mechanical system for the aforementioned IEWM and its control strategy are studied to get better driving maneuverability, ride comfort, driving safety, and posture stability of automobiles in this paper. The 6 degree of freedom (DOF) roll model of active suspension vibration with seats and multiobjective optimization controller are constructed for vehicle posture active control to solve the difficult trade-off between suspension dynamic deflection, roll angle, and seat vertical acceleration. The controller weight coefficients are optimized by an improved genetic algorithm (IGA) method, and the fitness function in piecewise form is adopted to reduce the search range. The simulation analysis shows that the combination of IGA and a multi-objective controller can defuse the conflict of goals between different suspension performance evaluation indexes, which also improves the overall suspension performances compared with the experience adjustment method and passive suspension system. In detail, this simple optimization control strategy can reduce the vertical acceleration root mean square value (RMSV) of the left and right seat by 45 % and 11 %, respectively; the left and right tire dynamic load decreased by 13 % and 2 %, respectively; and 25 % reduction in roll angle. These performance improvements only sacrifice part of suspension dynamic deflection RMSV increase, but do not affect driving safety.
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