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        Lactobacillus rhamnosus CCFM1107 treatment ameliorates alcohol -induced liver injury in a mouse model of chronic alcohol feeding

        Fengwei Tian,Feifei Chi,Gang Wang,Xiaoming Liu,Qiuxiang Zhang,Yongquan Chen,Hao Zhang,Wei Chen 한국미생물학회 2015 The journal of microbiology Vol.53 No.12

        Lactobacillus rhamnosus CCFM1107 was screened for high antioxidative activity from 55 lactobacilli. The present study attempted to explore the protective properties of L. rhamnosus CCFM1107 in alcoholic liver injury. A mouse model was induced by orally feeding alcohol when simultaneously treated with L. rhamnosus CCFM1107, the drug Hu-Gan- Pian (HGP), L. rhamnosus GG (LGG), and L. plantarum CCFM1112 for 3 months. Biochemical analysis was performed for both serum and liver homogenate. Detailed intestinal flora and histological analyses were also carried out. Our results indicated that the administration of L. rhamnosus CCFM1107 significantly inhibited the increase in the levels of serum aminotransferase and endotoxin, as well as the levels of triglyceride (TG) and cholesterol (CHO) in the serum and in the liver. Glutathione (GSH), glutathione peroxidase (GSH-Px) and superoxide dismutase (SOD) were elevated while the levels of malondialdehyde (MDA) were decreased. The enteric dysbiosis caused by alcohol was restored by increasing the numbers of both lactobacilli and bifidobacteria and decreasing the numbers of both enterococci and enterobacter. Histological analysis confirmed the protective effect of L. rhamnosus CCFM1107. Compared with the other lactobacilli and to the drug Hu-Gan-Pian, there is a high chance that L. rhamnosus CCFM1107 provides protective effects on alcoholic liver injury by reducing oxidative stress and restoring the intestinal flora.

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        Vibration control for serviceability enhancement of offshore platforms against environmental loadings

        Chih-Shiuan Lin,Feifei Liu,Jigang Zhang,Jer-Fu Wang,Chi-Chang Lin 국제구조공학회 2019 Smart Structures and Systems, An International Jou Vol.24 No.3

        Offshore drilling has become a key process for obtaining oil. Offshore platforms have many applications, including oil exploration and production, navigation, ship loading and unloading, and bridge and causeway support. However, vibration problems caused by severe environmental loads, such as ice, wave, wind, and seismic loads, threaten the functionality of platform facilities and the comfort of workers. These concerns may result in piping failures, unsatisfactory equipment reliability, and safety concerns. Therefore, the vibration control of offshore platforms is essential for assuring structural safety, equipment functionality, and human comfort. In this study, an optimal multiple tuned mass damper (MTMD) system was proposed to mitigate the excessive vibration of a three-dimensional offshore platform under ice and earthquake loadings. The MTMD system was designed to control the first few dominant coupled modes. The optimal placement and system parameters of the MTMD are determined based on controlled modal properties. Numerical simulation results show that the proposed MTMD system can effectively reduce the displacement and acceleration responses of the offshore platform, thus improving safety and serviceability. Moreover, this study proposes an optimal design procedure for the MTMD system to determine the optimal location, moving direction, and system parameters of each unit of the tuned mass damper.

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