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Eugenol Inhibits Calcium Currents in Dental Afferent Neurons
Lee, M. H.,Yeon, K.-Y.,Park, C.-K.,Li, H.-Y.,Fang, Z.,Kim, M. S.,Choi, S.-Y.,Lee, S. J.,Lee, S.,Park, K.,Lee, J.-H.,Kim, J. S.,Oh, S. B. SAGE Publications 2005 Journal of dental research Vol.84 No.9
<P>Eugenol is a topical analgesic agent widely used in the dental clinic. To elucidate the molecular mechanism underlying its analgesic action, we investigated the effect of eugenol on high-voltage-activated calcium channel (HVACC) currents in dental primary afferent neurons, and with a heterologous expression system. Dental primary afferent neurons were identified by retrograde labeling with a fluorescent dye, DiI. Eugenol inhibited HVACC currents in both capsaicin-sensitive and capsaicin-insensitive dental primary afferent neurons. The HVACC inhibition by eugenol was not blocked by capsazepine, a competitive transient receptor potential vanilloid 1 (TRPV1) antagonist. Eugenol inhibited N-type calcium currents in the cell line C2D7, stably expressing the human N-type calcium channels, where TRPV1 was not endogenously expressed. Our results suggest that the HVACC inhibition by eugenol in dental primary afferent neurons, which is not mediated by TRPV1 activation, might contribute to eugenol's analgesic effect. Abbreviations: high-voltage-activated calcium channel, HVACC; transient receptor potential vanilloid 1, TRPV1; trigeminal ganglion, TG; dorsal root ganglion, DRG; capsazepine, CZP.</P>
( Do Seung Lee ),( Kyung Hwan Boo ),( Jin Kyu Woo ),( Fang Meng Duan ),( Keun Hwa Lee ),( Taeg Kyu Kwon ),( Hyo Yeon Lee ),( Key Zung Riu ),( Dong Sun Lee ) 한국응용생명화학회(구 한국농화학회) 2011 Applied Biological Chemistry (Appl Biol Chem) Vol.54 No.2
Effects of methanol extract of Terminalia chebula on antibacterial activity and the generation of superoxide radical in Bacillus subtilis, as well as on syncytium formation and cytopathic activity in virus-infected baby hamster kidney cells were examined. The extract effectively inhibited syncytium formation in a concentration-dependent manner, and infectious virus production was markedly reduced. However, glycoprotein synthesis was not affected. These results collectively indicate that methanol extract of T. chebula potentially inhibit glycosylation by acting as a suppressor of intracellular glycosylation trafficking.
Stereo-epitaxial growth of single-crystal Ni nanowires and nanoplates from aligned seed crystals
Lee, H.,Yoo, Y.,Kang, T.,Lee, J.,Kim, E.,Fang, X.,Lee, S.,Kim, B. Royal Society of Chemistry 2016 Nanoscale Vol.8 No.19
<P>Epitaxially grown anisotropic Ni nanostructures are promising building blocks for the development of miniaturized and stereo-integrated data storage kits because they can store multiple magnetic domain walls (DWs). Here, we report stereo-epitaxially grown single-crystalline Ni nanowires (NWs) and nanoplates, and their magnetic properties. Vertical and inclined Ni NWs were grown at the center and edge regions of c-cut sapphire substrates, respectively. Vertical Ni nanoplates were grown on r-cut sapphire substrates. The morphology and growth direction of Ni nanostructures can be steered by seed crystals. Cubic Ni seeds grow into vertical Ni NWs, tetrahedral Ni seeds grow into inclined Ni NWs, and triangular Ni seeds grow into vertical Ni nanoplates. The shapes of the Ni seeds are determined by the interfacial energy between the bottom plane of the seeds and the substrates. The as-synthesized Ni NWs and nanoplates have blocking temperature values greater than 300 K at 500 Oe, verifying that these Ni nanostructures can form large magnetic DWs with high magnetic anisotropy properties. We anticipate that epitaxially grown Ni NWs and nanoplates will be used in various types of 3-dimensional magnetic devices.</P>
Mosquitocidal activity of penfluridol as juvenile hormone antagonist
Lee, Seok-Hee,Lim, Hee Nam,Choi, Jae Young,Park, Dong Hwan,Ahn, Byung Hoon,Fang, Ying,Kim, Jong Hoon,Park, Min Gu,Woo, Ra Mi,Lee, Bo Ram,Kim, Woo Jin,Ko, Young Kwan,Lee, Ill Young,Je, Yeon Ho 한국응용곤충학회 2018 Journal of Asia-Pacific Entomology Vol. No.
<P><B>Abstract</B></P> <P>Juvenile hormone antagonists (JHANs) are known to interfere with the formation of juvenile hormone (JH) receptor complex. JHANs might be effective for control of target pests in larval stages at which stages high level of endogenous JH titer is maintained. In order to identify novel insecticidal compounds, 2352 compounds were surveyed on their JHAN activities using the yeast-two hybrid system. Among 53 compounds with JHAN activities, penfluridol showed high level of insecticidal activity against larvae of <I>Aedes albopictus</I>. JHAN activity was increased in proportion to the concentration of penfluridol. Larvicidal activity of penfluridol was 1.3–2.0 folds higher than that of pyriproxyfen. These results suggested that penfluridol could be useful for control of mosquito larvae.</P> <P><B>Highlights</B></P> <P> <UL> <LI> 53 compounds have high level of JHAN activity. </LI> <LI> Among 53 compounds, penfluridol showed the highest mosquitocidal activity. </LI> <LI> Penfluridol showed a significant mosquitocidal activity compared with pyriproxyfen. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>