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Fanfan Lin,Xin Zhang,Fan Feng 전력전자학회 2019 ICPE(ISPE)논문집 Vol.2019 No.5
The dual active bridge (DAB) converter is attracting more and more attention nowadays for its advantages like higher power density and soft switching properties. However, the LC input filter which is often cascaded with DAB to improve input current quality sometimes leads to instability of the whole cascaded system. To analyze stability of this cascaded system with an LC input filter, this paper builds the full-order DAB closed-loop impedance model impedance with generalized state-space averaging method. The derived model is used in the minor loop gain of the cascaded system for stability assessment with Nyquist Criteria. And the effects of different PI controller parameters are analyzed. Experimental results validate the theoretical analysis.
Fan Feng,Xin Zhang,Peiyi Gao,Fanfan Lin,Bohui Zhao,Hoay Beng Gooi 전력전자학회 2019 ICPE(ISPE)논문집 Vol.2019 No.5
The emerging triple-phase-shift (TPS) modulation method has been successfully applied to the dual active bridge (DAB) converters, eliminating the circulating current and thus improving the efficiency. Hence the TPS-based DAB converter has been receiving greater attention in recent years. However, the interaction between the TPS-DAB converter and its LC filter may cause instable problems. This paper develops the impedance model of the TPS-DAB converter. With the developed input impedance model, the stability of the TPS-DAB converter and its LC filter is analyzed. The effects of the LC filter parameters on the stability of the TPS-DAB converter and the LC filter are clarified. Finally, the experimental results are provided for validating the impedance model and stability analysis.
Du Fu,Qi Xin,Zhang Aotong,Sui Fanfan,Wang Xuemin,Proud Christopher G.,Lin Cunzhi,Fan Xinglong,Li Jing 생화학분자생물학회 2021 Experimental and molecular medicine Vol.53 No.-
PD-L1 is abnormally regulated in many cancers and is critical for immune escape. Fully understanding the regulation of PD-L1 expression is vital for improving the clinical efficacy of relevant anticancer agents. TGF-β plays an important role in the low reactivity of PD-1/PD-L1 antibody immunotherapy. However, it is not very clear whether and how TGF-β affects PD-L1 expression. In the present study, we show that TGF-β upregulates the expression of the transcriptional coactivator MRTF-A in non-small-cell lung cancer cells, which subsequently interacts with NF-κB/p65 rather than SRF to facilitate the binding of NF-κB/p65 to the PDL1 promoter, thereby activating the transcription and expression of PD-L1. This leads to the immune escape of NSCLC cells. This process is dependent on the activation of the TGF-β signaling pathway. In vivo, inhibition of MRTF-A effectively suppresses the growth of lung tumor s y ngrafts with enrichment of NK and T cells in tumor tissue. Our study defines a new signaling pathway that regulates the transcription and expression of PD-L1 upon TGF-β treatment, which may have a significant impact on research into the application of immunotherapy in treating lung cancer.