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- 저자 : Fan Yajie (검색결과 4 건)
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Primordial Drivers of Diabetes Heart Disease: Comprehensive Insights into Insulin Resistance
Yajie Fan,Zhipeng Yan,Tingting Li,Aolin Li,Xinbiao Fan,Zhongwen Qi,Junping Zhang 대한당뇨병학회 2024 Diabetes and Metabolism Journal Vol.48 No.1
Insulin resistance has been regarded as a hallmark of diabetes heart disease (DHD). Numerous studies have shown that insulin resistance can affect blood circulation and myocardium, which indirectly cause cardiac hypertrophy and ventricular remodeling, participating in the pathogenesis of DHD. Meanwhile, hyperinsulinemia, hyperglycemia, and hyperlipidemia associated with insulin resistance can directly impair the metabolism and function of the heart. Targeting insulin resistance is a potential therapeutic strategy for the prevention of DHD. Currently, the role of insulin resistance in the pathogenic development of DHD is still under active research, as the pathological roles involved are complex and not yet fully understood, and the related therapeutic approaches are not well developed. In this review, we describe insulin resistance and add recent advances in the major pathological and physiological changes and underlying mechanisms by which insulin resistance leads to myocardial remodeling and dysfunction in the diabetic heart, including exosomal dysfunction, ferroptosis, and epigenetic factors. In addition, we discuss potential therapeutic approaches to improve insulin resistance and accelerate the development of cardiovascular protection drugs.
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Analysis on Pulse Shaping in Faster-than-Nyquist System
Yajie Ren,Jiancun Fan,Xinmin Luo,Xi Chen 대한전자공학회 2017 대한전자공학회 학술대회 Vol.2017 No.1
In faster-than-Nyquist (FTN) signaling, information symbols are transmitted at a rate higher than that suggested by the Nyquist criterion, which causes unavoidable inter-symbol interference (ISI). As one of the most important part in FTN systems, the selection of shaping pulses draws a lot of attention. Pulse shaping filters are necessary in wireless communication systems to generate band-limited signals and reduce ISI in transmission, and help to decrease the detection complexity as well. For sinc pulses, it has been established that with a small increase in the signaling rate beyond the Nyquist rate, there is no reduction in the minimum Euclidean distance for binary signaling. In this paper, we compare the waveforms of different shaping pulses, and present the ISI with different symbol accelerating factor. Furthermore, we do simulations with different shaping pulses and give the selection of pulses in FTN systems.
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Hu Yanchao,Zhang Chunyan,Fan Yajie,Zhang Yan,Wang Yiwen,Wang Congxia 대한약리학회 2022 The Korean Journal of Physiology & Pharmacology Vol.26 No.6
Recent research indicates that lactate promotes the switching of vascular smooth muscle cells (VSMCs) to a synthetic phenotype, which has been implicated in various vascular diseases. This study aimed to investigate the effects of lactate on the VSMC phenotype switch and the underlying mechanism. The CCK-8 method was used to assess cell viability. The microRNAs and mRNAs levels were evaluated using quantitative PCR. Targets of microRNA were predicted using online tools and confirmed using a luciferase reporter assay. We found that lactate promoted the switch of VSMCs to a synthetic phenotype, as evidenced by an increase in VSMC proliferation, mitochondrial activity, migration, and synthesis but a decrease in VSMC apoptosis. Lactate inhibited miR-23b expression in VSMCs, and miR-23b inhibited VSMC's switch to the synthetic phenotype. Lactate modulated the VSMC phenotype through downregulation of miR-23b expression, suggesting that overexpression of miR-23b using a miR-23b mimic attenuated the effects of lactate on VSMC phenotype modulation. Moreover, we discovered that SMAD family member 3 (SMAD3) was the target of miR-23b in regulating VSMC phenotype. Further findings suggested that lactate promotes VSMC switch to synthetic phenotype by targeting SMAD3 and downregulating miR-23b. These findings suggest that correcting the dysregulation of miR-23b/ SMAD3 or lactate metabolism is a potential treatment for vascular diseases.
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Experimental and theoretical analysis of element mercury adsorption on Fe3O4/Ag composites
Lu Dong,Jiangkun Xie,Guangping Fan,Yaji Huang,Jun Zhou,Qingke Sun,LiangWang,Zhengwen Guan,Di Jiang,Ye Wang 한국화학공학회 2017 Korean Journal of Chemical Engineering Vol.34 No.11
A novel magnetic nano-sorbent Fe3O4/Ag was synthesized and applied to capture the elemental mercury from the simulated flue gas. The morphology, components and crystal phase of the sorbents were characterized by transmission electron microscope (TEM), energy dispersive spectrometry (EDS) and X-ray diffraction (XRD), respectively. The mercury removal performance of the sorbents was investigated through the fixed-bed tests. The results indicated that silver was successfully loaded on the surface of Fe3O4 particles, which could significantly enhance the Hg0 removal performance of the sorbents. Flue gas components, including CO2, SO2, and NO, have little impact on the Hg0 removal performance of Fe3O4/Ag sorbents, while O2 has a slightly positive effect. The Hg0 removal efficiency decreased with the increasing of temperature, Hg0 inlet concentration and gas hourly space velocity. Only one broad mercury desorption peak at approximately 210 oC could be observed during the temperature-programmed desorption (TPD) process, which indicated that mercury species existing on the surface of Fe3O4/Ag sorbents might be elemental mercury instead of oxidized mercury. Furthermore, the reusability tests showed that the Fe3O4/Ag sorbents could be efficiently regenerated and reused. Finally, the theoretical analysis based on the DFT method showed that a weak chemisorption of Hg0 on Fe3O4 sorbents changed to a strong chemisorption when silver was loaded. The results of theoretical analysis conformed to the experiments results well.
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