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      • Fire performance of edge and interior circular steel-reinforced concrete-filled steel tubular stub columns

        Fan-Qin Meng,Mei-Chun Zhu,G. Charles Clifton,Kingsley U. Ukanwa,James B.P. Lim 국제구조공학회 2021 Steel and Composite Structures, An International J Vol.41 No.1

        The steel-reinforced concrete-filled steel tubular column (SRCFT) is a new form of composite columns. Before widely accepted in engineering practice, its fire behaviour shall be fully understood. Four representative circular SRCFT stub columns were built and tested to failure under ISO fire herein. The tests explored the effect of reinforced steel, the internal or external heating condition and load ratios. The experimental results indicated that the inserted section steel significantly improved the fire resistance of circular SRCFT columns. The non-uniform fire condition did not produce a detrimental effect on the fire response of the specimen. The numerical model was developed and validated against the experimental results. Then a parametric study was present to evaluate the effect of load level, eccentricity and heating conditions. A comparison was made to check the accuracy of a widely accepted design method. The comparison indicated the design method was generally 36% conservative for axially loaded condition and 25% un-conservative for eccentrically loaded condition.

      • Research of Acoustic Emission Testing Method with Application to Monitored for Wind Turbines

        Qin Hongwu,Zhang Chao,Zhang Xian,Fan Qinyin 보안공학연구지원센터 2015 International Journal of Multimedia and Ubiquitous Vol.10 No.1

        Acoustic Emission method of nondestructive check is based on exertion wave radiation and their registration during fast local material structure reorganization. It is used as a means of analysis of materials, constructions, productions control and diagnosis during operating time. In the article, it is applied to structural health monitoring of Wind Turbines. Acoustic emission testing is based condition monitoring system uses data already collected at the wind turbine controller. It is an effective way to monitor wind turbines for early warning of failures and performance issues. We used a number of measurements to develop anomaly detection algorithms and investigated classification techniques using clustering algorithms and principal components analysis for capturing fault signatures. When registering signal amplitude it is required to consider its frequency distribution connecting each amplitude rate with the corresponding vibration rate. The correlation and signal to noise ratio were evaluated by the algorithm based on frequency spectrum. Classical method of frequency distortion influence exclusion consists of FRF calculation with subsequent adjustment of received signals spectral characteristics.

      • KCI등재

        Comparative kinetic study of coal gasification with steam and CO2 in molten blast furnace slags

        Fan Yang,Qingbo Yu,Huaqing Xie,Zongliang Zuo,Limin Hou,Qin Qin 한국화학공학회 2018 Korean Journal of Chemical Engineering Vol.35 No.8

        To make a comparison between coal gasification in molten blast furnace slag (MBFS) in different ambience and choose an appropriate agent to recover BF slag’s waste heat entirely, coal gasification with steam and CO2 in molten blast furnace slags was studied by isothermal thermo-gravimetric analysis. The effects of temperature and addition of MBFS were studied. Carbon conversion and reaction rate increased with increasing temperature and MBFS. Volumetric model (VM), shrinking core model (SCM), and diffusion model (DM) were applied to describe the coal gasification behavior of FX coal. The most appropriate model describing the coal gasification was SCM in steam ambience and VM in CO2 ambience, respectively. The reaction rate constant k(T) in CO2 ambience is greater than that in steam ambience, which means the gasification reactivity of coal in CO2 ambience is better than that in steam ambience. BF slag can effectively reduce the activation energy EA of coal gasification reaction in different ambiences. But, the difference of activation energies is not large in different ambiences. Based on the results of kinetic analysis including k(T) and EA calculated by the established model, CO2 was chosen to be the most appropriate agent.

      • Resveratrol Inhibits Oesophageal Adenocarcinoma Cell Proliferation via AMP-activated Protein Kinase Signaling

        Fan, Guang-Hua,Wang, Zhong-Ming,Yang, Xi,Xu, Li-Ping,Qin, Qin,Zhang, Chi,Ma, Jian-Xin,Cheng, Hong-Yan,Sun, Xin-Chen Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.2

        Resveratrol has been examined in several model systems for potential effects against cancer. Adenosine monophosphate-activated protein kinase (AMPK) is reported to suppress proliferation in most eukaryocyte cells. Whether resveratrol via AMPK inhibits proliferation of oesophageal adenocarcinoma cells (OAC) is unknown. The aim of this study was to determine the roles of AMPK in the protective effects of resveratrol in OAC proliferation and to elucidate the underlying mechanisms. Treatment of cultured OAC derived from human subjects or cell lines with resveratrol resulted in decreased cell proliferation. Further, inhibition of AMPK by pharmacological reagent or genetical approach abolished resveratrol-suppressed OAC proliferation, reduced the level of $p27^{Kip1}$, a cyclin-dependent kinase inhibitor, and increased the levels of S-phase kinase-associated protein 2 (Skp2) of $p27^{Kip1}$-E3 ubiquitin ligase and 26S proteasome activity reduced by resveratrol. Furthermore, gene silencing of $p27^{Kip1}$ reversed resveratrol-suppressed OAC proliferation. In conclusion, these findings indicate that resveratrol inhibits Skp2-mediated ubiquitylation and 26S proteasome-dependent degradation of $p27^{Kip1}$ via AMPK activation to suppress OAC proliferation.

      • KCI등재

        Isolation and phylogenetic analysis of hemagglutinin gene of H9N2 influenza viruses from chickens in South China from 2012 to 2013

        Han-Qin Shen,Zhuan-Qiang Yan,Fan-Gui Zeng,Chang-Tao Liao,Qing-Feng Zhou,Jian-Ping Qin,Qingmei Xie,Yingzuo Bi,Feng Chen 대한수의학회 2015 Journal of Veterinary Science Vol.16 No.3

        As part of our ongoing influenza surveillance program in South China, 19 field strains of H9N2 subtype avian influenza viruses (AIVs) wereisolated from dead or diseased chicken flocks in Guangdong province, South China, between 2012 and 2013. Hemagglutinin (HA) genes ofthese strains were sequenced and analyzed and phylogenic analysis showed that 12 of the 19 isolates belonged to the lineage h9.4.2.5, whilethe other seven belonged to h9.4.2.6. Specifically, we found that all of the viruses isolated in 2013 belonged to lineage h9.4.2.5. The lineageh9.4.2.5 viruses contained a PSRSSR↓GLF motif at HA cleavage site, while the lineage h9.4.2.6 viruses contained a PARSSR↓GLF at thesame position. Most of the isolates in lineage h9.4.2.5 lost one potential glycosylation site at residues 200–202, and had an additional oneat residues 295–297 in HA1. Notably, 19 isolates had an amino acid exchange (Q226L) in the receptor binding site, which indicated that theviruses had potential affinity of binding to human like receptor. The present study shows the importance of continuing surveillance of newH9N2 strains to better prepare for the next epidemic or pandemic outbreak of H9N2 AIV infections in chicken flocks.

      • An Efficient Blind Detection Algorithm of Median Filtered Image

        Yongzhen Ke,Fan Qin,Weidong Min,Qiang Zhang 보안공학연구지원센터 2015 International Journal of Hybrid Information Techno Vol.8 No.1

        Due to the significant advances of digital photography and the availability of many powerful photo editing tools, it becomes easier to create forgery images by non-professional users. Median filtering that is usually applied to erase the forensically significant fingerprints has recently received increased attention. In this paper, we present an effective blind forensic algorithm to detect the median filtering manipulation. First, the median filtered residual (MFR) is generated by computing the difference between a testing image and a median filtered version of itself. Then, three feature sets including histogram, autocorrelation and gradient are extracted from the median filter residual. Last, those features are fetched into support vector machine (SVM) for training and classification. Our experimental results demonstrate that our proposed forensic method achieves not only better detection rate but also lower computational complexity compared with other existing median filtering detection methods. Our proposed forensic method also can locate local median filtering of image effectively.

      • Effect of original layer thicknesses on the interface bonding and mechanical properties of TiAl laminate composites

        Fan, Minyu,Domblesky, Joseph,Jin, Kai,Qin, Liang,Cui, Shengqiang,Guo, Xunzhong,Kim, Naksoo,Tao, Jie Elsevier 2016 Materials & Design Vol.99 No.-

        <P><B>Abstract</B></P> <P>It is of great significance in high-temperature aeroengine applications for large-surface-area TiAl laminate composites to be fabricated into Ti-Al<SUB>3</SUB>Ti parts by plastic forming and subsequent vacuum hot pressing. Then the original layer thicknesses have an important influence on the interface bonding and mechanical properties of TiAl laminate composites, but only few reports about it have been published so far. In the present study, vacuum hot pressing was employed to fabricate TiAl laminate composites using Ti and Al foils of different thickness. The resulting interface bond and mechanical properties of TiAl laminate composites were then studied to determine the optimum sheet configuration and thickness. To further assess their formability and develop a forming limit diagram (FLD), 0.1/0.15 TiAl laminate composites were operated on bending and forming tests to provide guidance for subsequent plastic forming of complex geometries. The results indicated that hot pressed laminates composed of alternating 0.1 (Al) and 0.15 (Ti) mm thick sheets exhibited enhanced superior interface bonding and mechanical properties compared with 0.2/0.25 and 0.4/0.4 sheets. The 0.1/0.15 TiAl laminate composites had excellent bending characteristics and reasonable formability. Fabrication of a drawn cup further confirms the potential for hot pressed TiAl laminate composites to be fabricated into complex shapes.</P> <P><B>Highlights</B></P> <P> <UL> <LI> The large-surface-area TiAl laminate composites were prepared by vacuum hot pressing. </LI> <LI> The effect of original layer thicknesses on the interface bonding and mechanical properties was investigated. </LI> <LI> Bending and forming tests proved the excellent bending characteristics and reasonable formability </LI> <LI> Fabrication of a drawn cup further confirmed the potential for complex shapes. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>

      • Internet Immunization Strategy based on Relations of Nodes

        Fan Tongrang,Qin Wanting,Zhao Wenbin,Wang Qian,Yu Tao 보안공학연구지원센터 2016 International Journal of Security and Its Applicat Vol.10 No.11

        Inspired by the biological immune system against outside invasion in nature, this paper propose a network security strategy using Agent technology. The Agents with independent behavior capacity are set for resisting network intrusion using their spontaneous coordinate organization. Based on the comparisons of existing immunization strategies, such as target immune, acquaintance immune and random immunity, it is found that the importance of nodes in network are influenced by interaction between nodes, degree of nodes, information flow, and other factors. If the nodes are more important, they have a greater influence over the whole network. When important nodes are infected by virus, there will be a higher probability of spreading of hazard information. Therefore, this paper proposes a network security model using Agent technology, where important nodes are implanted with relationship immunization strategy. Experimental results show when the network suffered from random or malicious attacks, relationship immunization strategy is more effective than others existing methods.

      • Multicentre Hospital-based Case-control Study of Diffuse Large B-cell Lymphoma in Shanghai, China

        Fan, Rong,Zhang, Lu-Yao,Wang, Hong,Yang, Bo,Han, Tao,Zhao, Xiao-Li,Wang, Wei,Wang, Xiao-Qin,Lin, Guo-Wei Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.7

        Background: Several potential risk factors have been identified for diffuse large B-cell lymphoma (DLBCL); however, epidemiological studies investigating the association between these risk factors and DLBCL have yielded inconsistent results. Objectives: To investigate potential medical, lifestyle, and environmental risk factors of DLBCL in Shanghai, China through a hospital-based case-control study. Method: One-hundred-and-forty-seven newly diagnosed DLBCL patients and 294 sex- and age-matched controls were recruited from 11 hospitals in Shanghai between 2003 and 2007. A standardized structured questionnaire was used to obtain patient data on demographics, medical history, family history, lifestyle, and environmental exposures. Conditional logistic regression models were used to estimate odds ratios (ORs), with 95% confidence intervals (CIs), for risk associated with each data category. Results: History of tuberculosis (TB) infection and "living on a farm" were positively associated with DLBCL (TB: OR=3.05, 95% CI: 1.19-7.80; farm: OR=1.82, 95% CI: 1.21-2.73). In contrast, taking traditional Chinese medicine was negatively associated with DLBCL (OR=0.36, 95% CI: 0.14-0.89). No significant correlation with DLBCL risk was found for any of the other potential risk factors (p>0.05), including but not limited to hair dyes, alcohol drinking, smoking, and home/workplace renovation within one year. Conclusions: Consistent with results from previous studies in other DLBCL case populations, traditional Chinese medicine appeared to have a direct or indirect protective effect against DLBCL. However, this study also identified a possible predisposition for DLBCL in TB sufferers and farmers.

      • SCOPUSSCIEKCI등재

        Morphological and Hemodynamic Parameters for Middle Cerebral Artery Bifurcation Aneurysm Rupture Risk Assessment

        Qin, Hao,Yang, Qixia,Zhuang, Qiang,Long, Jianwu,Yang, Fan,Zhang, Hongqi The Korean Neurosurgical Society 2017 Journal of Korean neurosurgical society Vol.60 No.5

        Objective : To investigate the morphological and hemodynamic parameters associated with middle cerebral artery (MCA) bifurcation aneurysm rupture. Methods : A retrospective study of 67 consecutive patients was carried out based on 3D digital subtraction angiography data. Morphological and hemodynamic parameters including aneurysm size parameters (dome width, height, and perpendicular height), longest dimension from the aneurysm neck to the dome tip, neck width, aneurysm area, aspect ratio, Longest dimension from the aneurysm neck to the dome tip (Dmax) to dome width, and height-width, Bottleneck factor, as well as wall shear stress (WSS), low WSS area (LSA), percentage of LSA (LSA%) and energy loss (EL) were estimated. Parameters between ruptured and un-ruptured groups were analyzed. Receiver operating characteristics were generated to check prediction performance of all significant variables. Results : Sixty-seven patients with MCA bifurcation aneurysm were included (31 unruptured, 36 ruptured). Dmax (p=0.008) was greater in ruptured group than that in un-ruptured group. D/W (p<0.001) and the percentage of the low WSS area ($0.09{\pm}0.13$ vs. $0.01{\pm}0.03$, p<0.001) were also greater in the ruptured group. Moreover, the EL in ruptured group was higher than that in unruptured group ($6.39{\pm}5.04$ vs. $1.53{\pm}0.86$, p<0.001). Multivariate regression analysis suggested D/W and EL were significant predictors of rupture of MCA bifurcation aneurysms. Correlation analyses revealed the D/W value was positively associated with the EL (R=0.442, p<0.01). Conclusion : D/W and EL might be the most two favorable factors to predict rupture risk of MCA bifurcation aneurysms.

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