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RISS 인기검색어
- 검색키워드
- 저자 : Ezequiel Uribe (검색결과 3 건)
- 무료
- 기관 내 무료
- 유료
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Memantine Reverses Social Withdrawal Induced by Ketamine in Rats
Ezequiel Uribe,José Landaeta,Richard Wix,Antonio Eblen 한국뇌신경과학회 2013 Experimental Neurobiology Vol.22 No.1
The objective of this study was to determine the effect of memantine on schizophrenia-like symptoms in a ketamine-induced social withdrawal model in rats. We examined therapeutic effects of memantine, an NMDA antagonist, and haloperidol, a classic antipsychotic drug, on this behavioral model. Administration of memantine (10 or 15 mgㆍkg-1) significantly reduced ketamine-induced social withdrawal, and this effect was more effective than that of haloperidol (0.25 mgㆍkg-1) by restoring the social interaction between rats with no modification in general motor activity. These results suggest that memantine could have a therapeutic potential for schizophrenia.
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Eduardo Sánchez-Mendoza,Nayadoleni Nieves,Gustavo Merchor,Ezequiel Uribe 한국뇌신경과학회 2016 Experimental Neurobiology Vol.25 No.6
Schizophrenia is considered a neurodevelopmental disorder; however, all the available treatment options are used when the disease becomes clinically significant in adolescence or early adulthood. Using a developmental rat model of schizophrenia, we examined whether neonatal treatment with memantine, an NMDA receptor modulator, can improve schizophrenic-like symptoms in adulthood. Early maternal deprivation in rats produces deficits in social interaction behaviors in adulthood. In contrast, memantine administrated in neonatal rats subjected to early maternal deprivation significantly reduces deficits in social interaction behaviors in adulthood. These results raise the possibility that pharmacological treatment with memantine at the early developmental stage helps people with a risk to develop schizophrenic-like symptoms.
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Richard Wix-Ramos,Antonio Eblen-Zajjur,Xiomara Moreno,Eduardo Capote,Gilbert González,Ezequiel Uribe 대한정신약물학회 2014 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.12 No.1
Objective: Research of electroencephalograph (EEG) power spectrum and mean frequency has shown inconsistent results inpatients with schizophrenic, schizoaffective and bipolar disorders during medication when compared to normal subjects thus;the characterization of these parameters is an important task. Methods: We applied quantitative EEG (qEEG) to investigate 38 control, 15 schizophrenic, 7 schizoaffective and 11 bipolar disordersubjects which remained under the administration of psychotropic drugs (except control group). Absolute spectral power (ASP),mean frequency and hemispheric electrical asymmetry were measured by 19 derivation qEEG. Group mean values were comparedwith non parametrical Mann-Whithney test and spectral EEG maps with z-score method at p<0.05. Results: Most frequent drug treatments for schizophrenic patients were neuroleptic+antiepileptic (40% of cases) or 2 neuroleptics(33.3%). Schizoaffective patients received neuroleptic+benzodiazepine (71.4%) and for bipolar disorder patients neuroleptic+antiepileptic (81.8%). Schizophrenic (at all derivations except for Fp1, Fp2, F8 and T6) and schizoaffective (only at C3)show higher values of ASP (+57.7% and +86.1% respectively) compared to control group. ASP of bipolar disorder patients didnot show differences against control group. The mean frequency was higher at Fp1 (+14.2%) and Fp2 (+17.4%) in bipolar disorderpatients than control group, but no differences were found in frequencies between schizophrenic or schizoaffective patientsagainst the control group. Majority of spectral differences were found at the left hemisphere in schizophrenic and schizoaffectivebut not in bipolar disorder subjects. Conclusion: The present report contributes to characterize quantitatively the qEEG in drug treated schizophrenic, schizoaffectiveor bipolar disorder patients.
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