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Byun, Eui-Hong,Kim, Woo Sik,Shin, A-Rum,Kim, Jong-Seok,Whang, Jake,Won, Choul-Jae,Choi, Yohan,Kim, Su-Young,Koh, Won Jung,Kim, Hwa-Jung,Shin, Sung Jae Springer 2012 Journal of molecular medicine Vol.90 No.3
<P>Tuberculosis (TB) caused by Mycobacterium tuberculosis (Mtb) is one of the most deadly infectious diseases, with approximately two million people dying of TB annually. An effective therapeutic method for activating dendritic cells (DCs) and driving Th1 immune responses would improve host defenses and further the development of a TB vaccine. Given the importance of DC maturation in eliciting protective immunity against TB, we investigated whether Rv0315, a newly identified Mtb antigen, can prompt DC maturation. We found that Rv0315 functionally activated DCs by augmenting the expression of the co-stimulatory molecules CD80 and CD86 as well as MHC class I/II molecules. Moreover, it increased DC secretion of the pro-inflammatory cytokines IL-6, IL-1 beta, and TNF-alpha. Unlike LPS, however, Rv0315 induced the secretion of IL-12p70, but not IL-10. In addition, Rv0315-treated DCs accelerated the proliferation of CD4(+) and CD8(+) splenic T cells from Mtb-infected mice, with increased levels of IFN-gamma, in syngeneic and allogeneic mixed lymphocyte reactions, indicating that Rv0315 contributes to Th1 polarization of the immune response. Importantly, both mitogen-activated protein kinases and nuclear factor kappa B signaling mediated the expression of DC surface markers and cytokines. Taken together, our results indicate that Rv0315 is a novel DC maturation-inducing antigen that drives T cell immune responses toward Th1 polarization, suggesting that Rv0315 plays a key role in determining the nature of the immune response to TB.</P>
Byun, Eui‐,Baek,Park, Sang‐,Hyun,Jang, Beom‐,Su,Sung, Nak‐,Yun,Byun, Eui‐,Hong John Wiley Sons, Ltd 2016 Journal of the Science of Food and Agriculture Vol.96 No.2
<P>BACKGROUNDThis study was designed to evaluate the antitumor activity of low-molecular-weight beta-glucan (LMBG) produced by gamma irradiation (50 kGy), using in vivo and in vitro models. RESULTSThe results indicate that treatment with LMBG increased the proliferation of murine peritoneal macrophages, and their production of tumor necrosis factor alpha and nitric oxide, to a greater extent than treatment with high-molecular-weight beta-glucan (HMBG). The activation of peritoneal macrophages by LMBG was mediated by both mitogen-activated protein kinases and nuclear factor-kappa B signaling. Interestingly, when administered prophylactically, LMBG significantly inhibited tumor growth and lung metastasis in mice injected with B16BL6 melanoma cells compared with the HMBG-treated group. In comparison with HMBG treatment, LMBG treatment also elevated cell proliferation, cytokine (interferon-gamma and interleukin-2) production, and CD8(+) T cell populations in splenocytes from tumor-bearing mice. CONCLUSIONThese data indicate that LMBG is important in eliciting antitumor activity through a non-specific immune response and may play a major role as a value-added product in the medical industry. (c) 2015 Society of Chemical Industry</P>