http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Byun, Eui-Baek,Kim, Hye-Min,Song, Ha-Yeon,Kim, Woo Sik Elsevier 2019 Food and chemical toxicology Vol.127 No.-
<P><B>Abstract</B></P> <P>Hesperidin is a flavonoid which occurs in citrus fruits. Hesperidin was gamma-irradiated at doses of 0, 30, 70, and 150 kGy. Gamma irradiation induced a decreased hesperidin peak, and a new radiolytic peak that gradually increased up to 150 kGy. The new radiolytic peak was fractionated, and the fractionated hesperidin derivative was used for subsequent experiments. Hesperidin gamma-irradiated at 150 kGy was toxic toward B16BL6 cells, but not toward bone marrow-derived macrophages. This cytotoxicity was exerted via induction of apoptosis, as reflected by the high population of double-positive cells, increased sub-G1 phase cells, depolarization of matrix metalloproteinase, production of reactive oxygen species, weakness of cell adhesion, changes in cell morphology, and inhibition of B16BL6 cell migration. Furthermore, 150 kGy gamma-irradiated hesperidin decreased the expression of Bcl-2 and pro-caspases-3 and -9, increased the expression of Bax and cytosolic cytochrome <I>c</I>, and increased the cleavage of poly ADP ribose polymerase. <I>In vitro</I> mechanistic study revealed that 150 kGy gamma-irradiated hesperidin achieved significantly greater inhibition of lung metastasis and growth of melanoma B16BL6 cells in C57BL/6 mice than non-irradiated intact hesperidin did. These results suggest that the structural modification of hesperidin induced by gamma irradiation could facilitate the development of anti-cancer drugs.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Gamma irradiation induced structural transformation of hesperidin. </LI> <LI> Gamma-irradiated hesperidin effectively induced apoptosis than unirradiated-hesperidin in B16BL6 melanoma cells through mitochondrial pathway. </LI> <LI> Gamma-irradiated hesperidin exhibited preventive and therapeutic effects in lung metastasis and tumor growth mice model. </LI> <LI> Gamma-irradiated hesperidin might be a candidate for cancer therapy. </LI> </UL> </P>