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Darwish Badran,Ayman El-Baz El-Agroudy,Amira Adly Kassab,Khaled Saad El-Bayoumi,Zienab Helmy Eldken,Noha Ramadan Mohammed Elswaidy 대한해부학회 2024 Anatomy & Cell Biology Vol.57 No.1
The world has witnessed tremendous advancements in nano-base applications. Zinc oxide nanoparticles (ZON) are widely used in food industry and medicine. Although their application is of important value, they may cause toxicity to body tissues. Peripheral blood mononuclear cells (PBMCs) proved its efficacy in tissue regeneration especially when it is preconditioned by activated platelet supernatant (APS). The aim of this study is to evaluate the effect of ZON on the gastric mucosa and the therapeutic role of the PBMCs preconditioned by APS in rats. Ten rats were donors and fifty rats were recipients. The recipients were divided into; control group, ZON group (10 mg/kg/day orally for five days) and preconditioned PBMCs group (1×107 once intravenously 24 hours after ZON). Gastric specimens were processed for histological, immunohistochemical, biochemical and quantitative real-time polymerase chain reaction studies. ZON group showed marked structural changes in the gastric mucosa. There was desquamation or deep ulceration of the epithelium. Cytoplasmic vacuoles and pyknotic nuclei were in glandular cells. Reduced proliferating cell nuclear antigen and increased tumor necrosis factor-α were in epithelial cells. There were significant elevation in malondialdahyde and reduction in glutathione, superoxide dismutase, and catalase. Enhancement in mRNA expression of nuclear factor kappa-B and cyclooxygenase-2 was detected. The preconditioned PBMCs group showed significant improvement of all parameters. So, ZON had cytotoxic effects on the gastric mucosa and the preconditioned PBMCs had a therapeutic effect on gastric mucosal damage after ZON.
Yacoub, Haitham Ahmed,Mahmoud, Wael Mahmoud,El-Baz, Hatim Alaa-Eldeen El-Din,Eid, Ola Mohamed,El-Fayoumi, Refaat Ibrahim,Mahmoud, Maged Mostafa,Harakeh, Steve,Abuzinadah, Osama H.A. Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.23
Background: Acute lymphoblastic leukemia (ALL) is the most common cancer diagnosed in children and represents approximately 25% of cancer diagnoses among those younger than 15 years of age. Aim and Objectives: This study investigated substitutions in the ATP synthase subunit 6 gene of mitochondrial DNA (mtDNA) as a potential diagnostic biomarker for early detection and diagnosis of acute lymphoblastic leukemia. Based on mtDNA from 23 subjects diagnosed with acute lymphoblastic leukemia, approximately 465 bp of the ATP synthase subunit 6 gene were amplified and sequenced. Results: The sequencing revealed thirty-one mutations at 14 locations in ATP synthase subunit 6 of mtDNA in the ALL subjects. All were identified as single nucleotide polymorphisms (SNPs) with a homoplasmic pattern. The mutations were distributed between males and females. Novel haplotypes were identified in this investigation: haplotype (G) was recorded in 34% in diagnosed subjects; the second haplotype was (C) with frequency of 13% in ALL subjects. Neither of these were observed in control samples. Conclusions: These haplotypes were identified for the first time in acute lymphoblastic leukemia patients. Five mutations able to change amino acid synthesis for the ATP synthase subunit 6 were associated with acute lymphoblastic leukemia. This investigation could be used to provide an overview of incidence frequency of acute lyphoblastic leukemia (ALL) in Saudi patients based on molecular events.
Yacoub, Haitham Ahmed,Mahmoud, Wael Mahmoud,El-Baz, Hatim Alaa El-Din,Eid, Ola Mohamed,ELfayoumi, Refaat Ibrahim,Elhamidy, Salem Mohamed,Mahmoud, Maged M. Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.21
Background: Acute lymphoblastic leukemia (ALL) is the most common cancer diagnosed in children and represents approximately 25% of cancer diagnoses among those younger than 15 years of age. Materials and Methods: This study investigated alterations in the displacement loop (d-loop) region of mitochondrial DNA (mtDNA) as a risk factor and diagnostic biomarker for early detection and diagnosis of acute lymphoblastic leukemia. Using mtDNA from 23 subjects diagnosed with acute lymphoblastic leukemia, the first 450 bp of the d-loop region were amplified and successfully sequenced. Results: This revealed 132 mutations at 25 positions in this region, with a mean of 6 alterations per subject. The d-loop alterations in mtDNA in subjects were all identified as single nucleotide polymorphisms in a homoplasmic distribution pattern. Mutant alleles were observed in all subjects with individual frequency rates of up to 95%. Thirteen mutant alleles in the d-loop region of mtDNA occurred with a high frequency. Novel alleles and locations were also identified in the d-loop of mtDNA as follows: 89 G insertions (40%), 95 G insertions (13%), 182 C/T substitutions (5%), 308 C insertions (19%), and 311 C insertions (80%). The findings of this study need to be replicated to be confirmed. Conclusions: Further investigation of the relationship between mutations in mitochondrial d-loop genes and incidence of acute lymphoblastic leukemia is recommended.
Cryptanalysis on a Scheme to Share Information via Employing a Discrete Algorithm to Quantum States
H. Amellal,A. Meslouhi,M. El Baz,Y. Hassouni,A. El Allati 한국물리학회 2017 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.70 No.5
Recently, Yang and Hwang [Int. J. Theor. Phys. 53, 224 (2014)] demonstrated that the scheme to share information via employing discrete algorithm to quantum states presented by Kang and Fang [Commun. Theor. Phys. 55, 239 (2011)] suffers from a major vulnerability allowing an eavesdropper to perform a measurement and resend attack. By introducing an additional checking state framework, the authors have proposed an improved protocol to overcome this weakness. This work calls into question the invoked vulnerability in order to clarify a misinterpretation in the same protocol stages also introduce a possible leakage information strategy, known as a faked state attack, despite the proposed improvement, which means that the same security problem may persist. Finally, an upgrading technic was introduced in order to enhance the security transmission.
Super Quantum Discord and Other Correlations For Tripartite GHZ-type Squeezed States
S. Rfifi,F. Siyouri,M. El Baz,Y. Hassouni 한국물리학회 2015 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.67 No.2
A comparison is made between normal discord, super quantum discord, and entanglement for the tripartite Greenberger-Horne-Zeilinger (GHZ)-type squeezed states. For this aim, we start by studying the behavior of quantum discord for tripartite GHZ-type squeezed states. Also, we verify the monotonicity of the super quantum discord according to weaker quantum measurements. This was done by manipulating the amount of quantum information lost during the disruption of our quantum system and by controlling the measurement strength. Furthermore, we calculate the entanglement for our system.