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( Ekta Yadav ) 대한간학회 2020 춘·추계 학술대회 (KASL) Vol.2020 No.1
Aims: Over the recent years, nanoparticle approach for targeted drug delivery is considered as a promising therapeutic method to improve the potential of antitumor agents. Since Trianthema portulacastrum (TP) leaves have been utilized as a strong hepatoprotective in Indian traditional medicinal system. Thus current study was designed to biofabricate, characterize and evaluate protective effect of TP extract mediated silver nanoparticles (AgTPNPs) against diethylnitrosamine (DEN) induced hepatocarcinoma in rat model. Methods: AgTPNPs were synthesized by co-precipitation method and different characterization techniques confirmed the formation of spherical crystalline nanoparticles with size range of 50-80 nm. Liver damage in rats was induced with a single dose of DEN (200 mg/kg) as well as double dose of phenobarbital. Simultaneously, animals were administered with AgTPNPs at two dose levels (10 and 20 mg/kg p.o.) for 16 weeks. At the end of study, serum biomarkers, hematological status, antioxidants enzymes and proinflammatory cytokines were examined to assess the protective effect of AgTPNPs along with histopathological studies. Results: DEN significantly induced the hepatocellular carcinoma in each group, which was significantly reversed (P<0.001) by AgTPNPs in a concentration dependent manner. A significant reduction in level of serum hepatic and non-hepatic marker enzymes, oxidative stress and different inflammatory markers via direct and indirect inhibition of NF-kB expression were observed in rats administered with AgTPNPs. Conclusions: Collectively, results demonstrated that AgTPNPs potentially ameliorated the damaging effects of DEN induced hepatocellular carcinoma and it can be utilized as an effective nano technology based anticancer approach.
Pankajkumar Yadav,Ekta Yadav,Amita Verma,Saima Amin 한국약제학회 2014 Journal of Pharmaceutical Investigation Vol.44 No.6
Poor water solubility is one of the reasons forerratic absorption after oral administration of furosemide(FSM), an antihypertensive loop diuretic. Self nano emulsifyingdrug delivery system (SNEDDS) is a novel drugdelivery system utilized to improve the water solubility,permeability and ultimately bioavailability. FSM solubilitywas determined in various vehicles oils, surfactants and cosurfactants. Self emulsification region for the rationaldesign of SNEDDS formulations were identified bypseudoternary diagrams. Developed formulations werecharacterized by zeta potential determination, droplet sizeanalysis, dilution test, viscosity determination, in vitrodissolution studies and in vivo pharmacodynamic evaluation. A remarkable increase in dissolution was observed forthe optimized SNEDDS when compared with the plainFSM and marketed formulation by in vitro dissolutionstudies. The pharmacological effect of FSM was improvedby SNEDDS formulation as compared to plain FSM. Thestudy confirmed that the SNEDDS formulation can be usedas a possible alternative to traditional oral formulations ofFSM to improve its bioavailability.
Catalytic growth of MWCNT using CVD and its application as opto-electronic humidity sensor
Singh Ekta,Kumar Utkarsh,Srivastava Richa,Yadav B. C 한국탄소학회 2020 Carbon Letters Vol.30 No.2
The present paper describes the efect of co-catalyst on the growth of multiwall carbon nanotube (MWCNT) by chemical vapor deposition (CVD) technique. The fascinating properties of CNT make them a suitable material for optoelectronic devices such as sensors, LED, solar cell, and feld emission displays. MWCNTs were fabricated using CVD, by decomposing ethanol over fnely dispersed Co metal as a catalyst at 750 °C. The efects of growth condition on the quality and morphology of MWCNTs were investigated by SEM, FTIR and XRD. SEM photographs show that the nanotubes are densely packed having a diameter of 10–15 nm. The bandgap was calculated by UV–visible spectroscopy and it was found varying from 3.08 to 3.5 eV by changing the substrates. The average size of tubes (length) was found to be 250 nm. FTIR exhibited that the synthesized MWCNTs were semiconducting in nature with the oxygen vacancies causing the variations in refractive index with the exposure of moisture.