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RISS 인기검색어
- 검색키워드
- 저자 : Duby, Marie-Hé (검색결과 6 건)
- 무료
- 기관 내 무료
- 유료
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Stabilization of monodisperse electrosprays in the multi-jet mode via electric field enhancement
Duby, Marie-Hé,lè,ne,Deng, Weiwei,Kim, Kyoungtae,Gomez, Tommaso,Gomez, Alessandro Elsevier 2006 Journal of aerosol science Vol.37 No.3
<P><B>Abstract</B></P><P>The electrospray of conducting liquids operated in the cone-jet mode is well known to have the unique ability of generating droplets uniform in size over a phenomenal range of sizes depending primarily on the liquid flow rate and physical properties. Since there is a monotonic dependence of size on flow rate, the liquid flow rates that can be dispersed are modest if the goal is to produce very small (below a few micrometers in diameter) droplets. Yet, this is precisely the application niche for which few, if any, atomization alternatives are available. Multiplexing the spray source is indispensable for the electrospray capabilities to have an impact in high-value-added applications. We report here on a novel approach to multiplexing based on a well-known, but hitherto unexploited, regime of operation, the multi-jet mode. Ordinarily, such a mode is rather unsteady and the range of flow rates at which appreciable multiplexing is achieved is small. However, if the multi-jet mode is anchored by some sharp features (e.g., grooves, ridges, etc.) machined at the outlet of the atomizer, to intensify the electric field at discrete points around its perimeter, then the cone-jets are simultaneously anchored at these features and a stable mode of operation is identified over several hundreds of volts and a broad range of flow rates. Most importantly, so long as the machining is accurately reproduced from point to point, droplets generated do not vary significantly in size from spray to spray. As a result, a compact, inexpensive and versatile multiplexing system is realized without sacrificing droplet monodispersity.</P>
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김경태(Kyoungtae Kim),Marie-Helene Duby,Weiwei Deng,Tommaso Gomez,Alessandro Gomez,김상수(Sangsoo Kim) 대한기계학회 2006 대한기계학회 춘추학술대회 Vol.2006 No.6
The multiplexing system which can retain the characteristics of the cone-jet mode is indispensable for the<br/> electrospray capabilities to have an impact in high-value-added application. This experiment reports a novel<br/> approach to multiplexing based on a well-known, but hitherto unexploited, the multi-jet mode. Ordinarily,<br/> such a mode is rather unsteady and the range of flow rates at which appreciable multiplexing is achieved is<br/> small. However, if the multi-jet mode is anchored by grooves machined at the outlet of the atomizer, to<br/> intensify the electric field at discrete points around its perimeter, then the cone-jets are simultaneously<br/> anchored at these grooves and a stable mode of operation is identified over several hundreds of volts and<br/> abroad range of flow rates. So long as the machining is accurately reproduced, droplets generated uniformly at<br/> each spray. As a result, a compact, inexpensive and versatile multiplexing system is realized without<br/> sacrificing droplet monodispersity.
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Eom, Gwang Hyeon,Nam, Yoon Seok,Oh, Jae Gyun,Choe, Nakwon,Min, Hyun-Ki,Yoo, Eun-Kyung,Kang, Gaeun,Nguyen, Vu Hong,Min, Jung-Joon,Kim, Jong-Keun,Lee, In-Kyu,Bassel-Duby, Rhonda,Olson, Eric N.,Park, Woo Grune & Stratton 2014 Circulation research Vol.114 No.7
<P><B><U>Rationale:</U></B></P><P>Histone deacetylases (HDACs) are closely involved in cardiac reprogramming. Although the functional roles of class I and class IIa HDACs are well established, the significance of interclass crosstalk in the development of cardiac hypertrophy remains unclear.</P><P><B><U>Objective:</U></B></P><P>Recently, we suggested that casein kinase 2α1–dependent phosphorylation of HDAC2 leads to enzymatic activation, which in turn induces cardiac hypertrophy. Here we report an alternative post-translational activation mechanism of HDAC2 that involves acetylation of HDAC2 mediated by p300/CBP-associated factor/HDAC5.</P><P><B><U>Methods and Results:</U></B></P><P>Hdac2 was acetylated in response to hypertrophic stresses in both cardiomyocytes and a mouse model. Acetylation was reduced by a histone acetyltransferase inhibitor but was increased by a nonspecific HDAC inhibitor. The enzymatic activity of Hdac2 was positively correlated with its acetylation status. p300/CBP-associated factor bound to Hdac2 and induced acetylation. The HDAC2 K75 residue was responsible for hypertrophic stress–induced acetylation. The acetylation-resistant Hdac2 K75R showed a significant decrease in phosphorylation on S394, which led to the loss of intrinsic activity. Hdac5, one of class IIa HDACs, directly deacetylated Hdac2. Acetylation of Hdac2 was increased in Hdac5-null mice. When an acetylation-mimicking mutant of Hdac2 was infected into cardiomyocytes, the antihypertrophic effect of either nuclear tethering of Hdac5 with leptomycin B or Hdac5 overexpression was reduced.</P><P><B><U>Conclusions:</U></B></P><P>Taken together, our results suggest a novel mechanism by which the balance of HDAC2 acetylation is regulated by p300/CBP-associated factor and HDAC5 in the development of cardiac hypertrophy.</P>
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High rate diffusion-scale approximation for counters with extendable dead time
Chen Dubi,Rami Atar 한국원자력학회 2019 Nuclear Engineering and Technology Vol.51 No.6
Measuring occurrence times of random events, aimed to determine the statistical properties of thegoverning stochastic process, is a basic topic in science and engineering, and has been the subject ofnumerous mathematical modeling approaches. Often, true statistical properties deviate from measuredproperties due to the so called dead time phenomenon, where for a certain time period followingdetection, the detection system is not operational. Understanding the dead time effect is especiallyimportant in radiation measurements, often characterized by high count rates and a non-reducibledetector dead time (originating in the physics of particle detection). The effect of dead time can beinterpreted as a suitable rarefied sequence of the original time sequence. This paper provides a limit theorem for a high rate (diffusion-scale) counter with extendable (Type II)dead time, where the underlying counting process is a renewal process with finite second moment forthe inter-event distribution. The results are very general, in the sense that they refer to a general interarrival time and a random dead time with general distribution. Following the theoretical results, we will demonstrate the applicability of the results in three applications:serially connected components, multiplicity counting and measurements of aerosol spatialdistribution.
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