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Anti-Fatigue Effects of Fermented Rhodiola rosea Extract in Mice
Dong-Zhou Kang,Hee-Do Hong,Kyung-Im Kim,Sang Yoon Choi 한국식품영양과학회 2015 Preventive Nutrition and Food Science Vol.20 No.1
Rhodiola rosea is a perennial plant which grows in the alpine regions of Europe and Asia. Although the protective effects of R. rosea extract from fatigue due to exercise stress have been reported, studies on fermented R. rosea extract remain insufficient to date. Therefore, this study was conducted to examine the protective effects of fermented R. rosea extract against fatigue and exercise stress. As a result, fermented R. rosea extract was found to significantly increase swimming time, hepatic superoxide dismutase content, and serum lactate dehydrogenase in mice, while decreasing serum blood urea nitrogen content compared to R. rosea extract. Given the above results, it is considered that fermented R. rosea extract effectively protects against fatigue caused by strenuous exercise.
Effects of Fermented Ginseng Extracts on Tumor Metastasis in Mice
Dong Zhou Kang,Dan Liu,Seon Yoong Jo,강태봉,Jin Moo Lee,서형주,Ae-jung Kim,윤택준 한국식품과학회 2010 Food Science and Biotechnology Vol.19 No.6
This study was demonstrated that the fermentation of gingseng increases its biological activities,by comparing the anti-tumor and immunostimulating activities of fermented gingseng extracts (FginE) with those of non-fermented ginseng (GinE). In the experimental lung metastasis of colon26-M3.1 carcinoma, the intraperitoneal (i.p.) or peroral (p.o.) administration of FginE showed stronger anti-tumor metastatic activities than those of GinE. When stimulating 2 kinds of extract on macrophages,FginE was shown to have a higher production of interleukin (IL)-12 than GinE. In addition, treatment with FginE induced tumoricidal activity of peritoneal macrophages against colon26-M3.1 cells. When Peyer's patch was cocultured with FginE, the proliferation of these cells and granulocyte macrophage-colony stimulating factor (GMCSF)production were induced. In an assay for natural killer (NK) cell activity, an i.p. administration of FginE significantly augmented NK cytotoxicity against Yac-1tumor cells. Fermented ginseng extracts promotes antitumor activities to inhibit tumor metastasis, and its antitumor effects are associated with the enhancement of systemic as well as mucosal immune systems.
Anti-Fatigue Effects of Fermented Rhodiola rosea Extract in Mice
Kang, Dong-Zhou,Hong, Hee-Do,Kim, Kyung-Im,Choi, Sang Yoon The Korean Society of Food Science and Nutrition 2015 Preventive Nutrition and Food Science Vol.20 No.1
Rhodiola rosea is a perennial plant which grows in the alpine regions of Europe and Asia. Although the protective effects of R. rosea extract from fatigue due to exercise stress have been reported, studies on fermented R. rosea extract remain insufficient to date. Therefore, this study was conducted to examine the protective effects of fermented R. rosea extract against fatigue and exercise stress. As a result, fermented R. rosea extract was found to significantly increase swimming time, hepatic superoxide dismutase content, and serum lactate dehydrogenase in mice, while decreasing serum blood urea nitrogen content compared to R. rosea extract. Given the above results, it is considered that fermented R. rosea extract effectively protects against fatigue caused by strenuous exercise.