http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
권강범,Eun-KyungKim,신병철,Eun-ASeo,Jeong-YehYang,Do-GonRyu 생화학분자생물학회 2003 Experimental and molecular medicine Vol.35 No.2
Herba houttuyniae has been used as a constituent of herval medicine prescriptions for the treatment present study, we investigated the celular efects of herba houttuyniae extract (HE) and the signal pathways of HHE-induced apoptosis in HL-60 hu-man promyelocytic leukemia cell line. HHE treat-ment caused apoptosis of cels as evidenced by discontinuous fragmentation of DNA, the los of mitochondrial membrane potential, release of mi-tochondrial cytochrome c into the cytosol, activa-tion of procaspase-9 and caspase-3, and proteo-lytic cleavage of poly(ADP-ribose) polymerase. inhibitor, or cyclosporin A, a mitochondrial per-meability transition inhibitor, completely abolished HHE-induced DNA fragmentation. Together, these results suggest that HE possibly causes mito-chondrial damage leading to cytochrome c release into cytosol and activation of caspases resulting in PARP cleavage and execution of apoptotic cel death in HL-60 cells.