α-Calcium sulfate hemihydrate bioceramic prepared via salt solution method to enhance bone regenerative efficiency

Dieu Linh Tran,Anh Phuong Nguyen Hong,Ngoc Hoi Nguyen,Ngoc Trinh Huynh,Bao Ha Le Tran,Cam Tu Tran,Minh Dung Truong,Quan Dang Nguyen,박기동,Dai Hai Nguyen 한국공업화학회 2023 Journal of Industrial and Engineering Chemistry Vol.120 No.-

α-calcium sulfate hemihydrate (α-HH) was synthesized by salt solution methods to prepare a promising biomaterial for bone tissue repair and regeneration. The successful synthesis of α-HH was evaluated by field emission scanning electron microscopy (FE-SEM), thermogravimetric analysis (TGA), X-ray diffraction (XRD), and Fourier transform infrared (FTIR) scanning. The sterility of α-HH before and after irradiation with gamma ray was firstly confirmed by Colonies Forming Units (CFU) counting assay, to target the surgical grade application. In vitro tetrazolium bromide (MTT) assay, crystal violet (CV) and acridine orange (AO) staining was performed to assess the initial cytotoxicity and cell attachment ability of α-HH. Further in vivo implantation into rabbit distal femoral condyles defect exhibited the ability of salt solution-synthesized α-HH to promote the localization of osteocytes and osteoblasts, which improve the bone tissue repair and regeneration. The findings suggested that α-calcium sulfate hemihydrate synthesized by salt solution method is a potential material that can be used as bone substitutes.

Factors Affecting Logistics Capabilities for Logistics Service Providers: A Case Study in Vietnam

Dinh Dao DANG,Dieu Linh HA,Van Bao TRAN,Van Tuan NGUYEN,Thi Lien Huong NGUYEN,Thuy Hong DANG,Thi Thai Ha LE 한국유통과학회 2021 The Journal of Asian Finance, Economics and Busine Vol.8 No.5

This study aimed to investigate the factors affecting Logistics capabilities for Logistics Service Providers in Vietnam. Researchers inherited and developed based on previous research to focus on analyzing and evaluating dynamics, measuring Logistics capabilities, and the factors affecting Logistics capabilities for Logistics Service Providers. The logistics capabilities Model is used based on three factors: customer demand management capability, innovation capability, and information management capability. The empirical analysis used data from the survey data of l90 managers of Logistics Service Providers in Hai Phong, Ho Chi Minh City, Da Nang, Hue, Hanoi with reliable tools (SPSS 26.0 software). The data were analyzed by frequencies, percentages, means, Pearson’s Linear Correlation Coefficient, exploratory factor analysis, and multi-linear regression model based on the survey data. The research results identified the following factors affecting Logistics capabilities for Logistics Service Providers: innovation capability has the strongest impact on Logistics capabilities; customer demand management capability has the following strong effects on Logistics capabilities; and finally, information management capability that affects Logistics capabilities. There is also a positive relationship between all factors and Logistics capabilities. Several recommendations are further suggested to enhance to improve Logistics capabilities for Logistics Service Providers in Vietnam.

Determinants of Accountants' Loyalty Underlying Investment Management: Evidence from FDI Firms in Thanglong Industrial Park

NGUYEN, Dang Huy,HA, Son Tung,TRAN, Manh Linh,NGUYEN, Duc Thang,NGUYEN, Thi Xuan Hong,NGUYEN, Dieu Linh,DO, Duc Tai Korea Distribution Science Association 2020 The Journal of Asian Finance, Economics and Busine Vol.7 No.4

The research aims to investigate the impact levels of determinants on the loyalty of accountants to FDI firms underlying investment management in Thanglong Industrial Park in Hanoi, Vietnam. We conducted a questionnaire consisting of 31 observation variables with a 5-point Likert scale. Independent variables were measured from 1 "without effect" to 5 "strongly". The method of data collection was done through the survey and subjects are accountants in FDI firms doing business in Thanglong Industrial Park in Hanoi. After checking the information on the votes, there are 120 questionnaires with full information for data entry and analysis, This study employs Cronbach's Alpha test, and regression model. The results show that seven determinants including Working environment, The characteristics of working; Training, promotion prospects and development; Income, Personal characteristic, Collective work together and The method of leading had positive relationships with the loyalty of accountants. Based on the findings, some recommendations are given related to such determinants to improve the loyalty of accountants of FDI firms in general and FDI firms in Thanglong Industrial Park in Hanoi in particular. With which, those firms can enhance performance, reduce financial strain, saving on investment in the recruiting process of new staff, increase profitability to ensure investment management.

Work Motive Distribution of Public Universities Lecturers in Hanoi

PHAM, Ngoc Thach,BUI, Van Huyen,HA, Dieu Linh,LE, Thi Lan Huong Korea Distribution Science Association 2022 유통과학연구 Vol.20 No.11

Purpose: The study aims to investigate the impact of factors affecting the work motive distribution of public universities lecturers in Hanoi. Research design, data and methodology: The questionnaire survey method is applied in this research to analyze the relationship between the variables and verify the hypothesis based on the collected 306 valid questionnaires. The partial least square method structural equation model (PLS-SEM) is used to carry out structural equation modeling to study the relationship between latent variables with reliable tools (SmartPLS 3.0 software). Results: The research results show that the intrisic motivation of the lecturers, the extrisic motivation of the lecturers and the job characteristics of the lecturers all have a positive impact on the motivation of public universities lecturers in Hanoi. In which, intrinsic motivation has the greatest influence on the work motive distribution of lecturers. In addition, the research results also prove that job characteristics affect the work motive distribution of lecturers. This is a new factor in the factors affecting the work motive distribution of public universities lecturers. Conclusion: Based on the research results, the authors propose some recommendations to increase the work motive distribution of public universities lecturers in Hanoi through improving the factors affecting their work motive distribution.

Orodispersible film incorporating nanoparticulate loratadine for an enhanced oral bioavailability

Van Nguyen Khanh,Dang Thu Kim,Vu Linh Thi Dieu,Ha Nhan Thi,Truong Hieu Duy,Tran Tuan Hiep 한국약제학회 2023 Journal of Pharmaceutical Investigation Vol.53 No.3

Purpose Loratadine (LOR), a commonly prescribed antihistamine, has low water solubility but high permeability. In this study, an orodispersible film incorporating the nanoparticulate loratadine was prepared to enhance the oral bioavailability of a poorly water-soluble drug. Methods Nanoparticulate loratadine was formulated using the antisolvent precipitation method and optimized by a singlefactor design based on the particle size and polydispersity index. The optimal formulation was spray-dried and characterized by powder X-ray diffraction and differential scanning calorimetry. Nanoparticulate loratadine was loaded into an orodispersible film using a solvent casting method. Results In the dissolution tests, the nanoparticulate loratadine-loaded orodispersible film exhibited a 6.5-fold higher dissolution rate than the pure loratadine-loaded film and a similar dissolution rate compared to the commercialized orodispersible tablet, Loratadine SPM. In pharmacokinetic studies conducted on rats, the maximum concentration (Cmax) and area under the curve of the plasma concentration–time profile from 0 to 24 h (AUC 0-24 h) of the nanoparticulate loratadine-loaded orodispersible film significantly increased 1.8-fold and 5.8-fold, respectively. The elimination half-life (t1//2) increased 5.1-fold compared to the loratadine-loaded counterpart. Conclusion These results suggest the potential of orodispersible films to improve the oral bioavailability of poorly watersoluble drugs and promote compliance in pediatric and geriatric patients.

A Taguchi approach with electron-beam irradiation to optimize the efficiency of removing enrofloxacin from aqueous media

Hong Thi Bich Truong,Hiep Nghia Bui,Hieu Trung Nguyen,Thanh-Luu Pham,Duy Ngoc Nguyen,Yuan-Shing Perng,Linh Thi My Lam,Thi-Dieu-Hien Vo,Van-Truc Nguyen,Ha Manh Bui 한국화학공학회 2022 Korean Journal of Chemical Engineering Vol.39 No.4

Electron-beam (EB) irradiation was employed to degrade enrofloxacin (ENR) in an aqueous solution. Thealgal growth inhibition test revealed that ENR exhibited low toxicity against the cyanobacterium Arthrospira sp., with anEC50-96 h value of 5.17mg/L. The Taguchi design also involved finding the best optimum for ENR treatment using EB. Results revealed that the high-efficiency removal of ENR in an aqueous solution was approximately 98.53% under theoptimum conditions of an absorbed dose of 5 kGy, a pH of 5.0, and an initial ENR concentration of 10 mg/L and anH2O2 concentration of 2mM. The ERR degradation under a couple of EB irradiation and H2O2 followed pseudo-firstorderkinetics, with an R2 of ~0.970. The major degradation pathways of ENR were suggested by density functional theory,natural bond orbital calculations, and liquid chromatography-tandem mass spectrometry (LC/MS/MS) analysis. Lifecycle assessment (LCA) was also performed to evaluate the impact of the EB on removing ENR; the industrial processwas designed based on laboratory tests aimed with the ReCiPe tool. The obtained results indicated that energy consumptionand H2O2 affect environmental impacts with order human health, ecology systems, and natural resource. The LCAalso proved that EB could be a green and efficient method for eliminating pharmaceutical contaminants in water.