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Can Electroacupuncture Be Useful in Opioid-Induced Hyperalgesia? A Case Report
Di Carlo Marco,D’Addario Antonio,Salaffi Fausto 사단법인약침학회 2023 Journal of Acupuncture & Meridian Studies Vol.16 No.5
Opioid-induced hyperalgesia (OIH) is characterized by a paradoxical increase in pain sensitivity following opioid exposure. Although animal models indicate that electroacupuncture (EA) is effective against pain sensitization, there are no reports of its clinical application in OIH treatment. This case report involves an adult patient with osteomalacia complicated by multiple vertebral fragility fractures. The patient developed OIH following the use of oxycodone to treat severe disabling lower back pain that was refractory to nonsteroidal anti-inflammatory drugs. After hospitalization and treatment with low EA-frequency (2-10 Hz) sessions, the patient exhibited significant pain reduction and functional recovery after the first session, which was accompanied by steady progressive improvement as the treatment continued. This case report illustrates the clinical efficacy of EA in OIH treatment and indicates that EA, which has multiple modes of action on the neurobiology of chronic pain, has potential applications in the management of complex and difficult-to-manage conditions, such as OIH.
Gangrenous cholecystitis in male patients
Carlos Augusto Gomes,Cleber Soares Junior,Salomone Di Saverio,Massimo Sartelli,Poliana Graciele de Souza Silv,Agnes Silva Orlandi,Thais Lacerda Heringer,Felipe Couto Gomes,Fausto Catena 한국간담췌외과학회 2019 Annals of hepato-biliary-pancreatic surgery Vol.23 No.1
Backgrounds/Aims: The prevalence and risk factors of gangrenous cholecystitis in male are unknown. Objective: To verify the prevalence and risk factors of gangrenous cholecystitis in males. Methods: This cross-sectional study includes 95 patients (59.5±17.1 years), with clinical and histopathological diagnosis, operated laparoscopically on 2012-2016. Eligibility was decided based on the variables of age; tachycardia (>100 bpm); leukocytosis (>10,000/mm³); Murphy’s sign; gallbladder wall thickness (>4 mm); biochemical tests, morbidities (diabetes, alcoholism, smoking) and mortality. Multivariate regression, the chi-squared and Prevalent Chances Ratio (PCR) were used to define a few parameters. Results: The prevalence of gangrenous cholecystitis in men older than 50 years was 29.3%. The risk factors for the disease were as follows: diabetes mellitus (p=0.006, RCP=4.191), leukocytosis (p=0.003), gallbladder thickness greater than 4 mm (p=0.035, RCP=3.818), which increased mortality [(p=0.04) (RCP=8.001)]. Murphy’s sign showed a negative association (p=0.002, RCP=0.204). Values close to significance were observed in relation to gamma glutamyl transferase (p=0.083, RCP=3.125) and hospital stay (p=0.061, RCP=2.765). Conclusions: Male gender, and age older than 50 years, were correlated with a high prevalence of necrosis, higher than that reported in females. The risk factors for developing necrosis are the same as those described for female patients.
Sardinian honeys as sources of xanthine oxidase and tyrosinase inhibitors
Di Petrillo, Amalia,Santos-Buelga, Celestino,Era, Benedetta,Gonzalez-Paramas, Ana Maria,Tuberoso, Carlo Ignazio Giovanni,Medda, Rosaria,Pintus, Francesca,Fais, Antonella 한국식품과학회 2018 Food Science and Biotechnology Vol.27 No.1
Sardinian honeys obtained from different floral sources (Arbutus, Asphodelus, Eucalyptus, Thistle, and Sulla) were evaluated for their ability to inhibit tyrosinase and xanthine oxidase enzymes and for their antioxidant activity. Physicochemical parameters, total phenolic, and flavonoids content were also determined. Honey from Arbutus flowers had the highest antioxidant activity followed by Eucalyptus and Thistle ones. These three honeys showed good tyrosinase and xanthine oxidase inhibition properties. Thus, these Sardinian honeys could have a great potential as antioxidant sources for pharmaceutical and cosmetic applications.
Voice Recognition Systems Toward a Universal Language
Di´ez-Carrera, Carmen,Gonza´lez-Ruiz, Carlos Institute for University Language Sejong Instituti 2003 Journal of Universal Language Vol.4 No.2
An analysis of the major achievements of the last quarter of a century (means of transport and of communication, microelectronics, the conquest of Space, the globalisation of Society, computer networks, blocks of countries, the proliferation of International organisms and so on) would seem to suggest the need for a scientific study into the possibilities of a universal language. A real need exists, every day more pronounced and we consider that this is the right time for this investigation. As part of this project a discussion of possible alternative solutions is proposed (the use of a multi-lingual approach, English, multilingual intercompression, an international auxiliary language, "manufactured" languages, automatic translation, natural language, among others). There is also a definition of the theoretical specifications which this language should meet, taking into account all the current needs and the sectors involved (voice recognition, automatic translation, operative systems, programming languages, documentation, simple cross-cultural learning). The idea is based on a dual focus: person-to-person communication and person-to-machine communication. In order to achieve this double objective we shall select a set of universal sounds and phonemes which are common and understood by all people. The selection of this set of universal sounds and phonemes will e such that it will be easy to undertake a spectral discrimination. The phonetic, lexical and grammatical organization of the language will be established according to distinct levels of difficulty. Written forms will be expressed making use of the most appropriate phonetic transcription in each language. Design and development will be based on the Internet as a platform for investigation, cooperation and the consensus of hundreds of experts and a strategy is proposed for learning and spreading the language.
Effects of various prophylactic procedures on titanium surfaces and biofilm formation
Di Salle, Anna,Spagnuolo, Gianrico,Conte, Raffaele,Procino, Alfredo,Peluso, Gianfranco,Rengo, Carlo Korean Academy of Periodontology 2018 Journal of Periodontal & Implant Science Vol.48 No.6
Purpose: The aim of this study was to evaluate the effects of various prophylactic treatments of titanium implants on bacterial biofilm formation, correlating surface modifications with the biofilms produced by Pseudomonas aeruginosa PAO1, Staphylococcus aureus, and bacteria isolated from saliva. Methods: Pure titanium disks were treated with various prophylactic procedures, and atomic force microscopy (AFM) was used to determine the degree to which surface roughness was modified. To evaluate antibiofilm activity, we used P. aeruginosa PAO1, S. aureus, and saliva-isolated Streptococcus spp., Bacteroides fragilis, and Staphylococcus epidermidis. Results: AFM showed that the surface roughness increased after using the air-polishing device and ultrasonic scaler, while a significant reduction was observed after using a curette or polishing with Detartrine ZTM (DZ) abrasive paste. In addition, we only observed a significant (P<0.01) reduction in biofilm formation on the DZ-treated implant surfaces. Conclusion: In this study, both AFM and antibiofilm analyses indicated that using DZ abrasive paste could be considered as the prophylactic procedure of choice for managing peri-implant lesions and for therapy-resistant cases of periodontitis.
Giovanardi Carlo Maria,Gonzalez-Lorenzo Marien,Poini Alessandra,Marchi Eleonora,Culcasi Antonio,Ursini Francesco,Faldini Cesare,Martino Alberto Di,Mazzanti Umberto,Campesato Emanuela,Matrà Annunzio,Ce 한국한의학연구원 2023 Integrative Medicine Research Vol.12 No.3
Background Conventional therapies (CTs), pharmacological (PH) and non–pharmacological (NPH), do not always achieve benefits in the treatment of chronic low back pain (CLBP). We assessed efficacy and safety of acupuncture for CLBP as alternative or addition to CT. Methods We included randomised controlled trials (RCTs) comparing acupuncture alone or in combination with CT to CT. We searched Medline, Cochrane Library, Embase up to May 2022. We assessed risk of bias with the original Cochrane tool and GRADE certainty of evidence. Results were pooled through meta-analysis. Results Ten RCTs (2122 participants) were included comparing acupuncture versus CT and 6 (374 participants) comparing acupuncture plus CT to CT alone. Comparing acupuncture with NPH or PH, no differences were found for pain and disability. Comparing with combined PH and NPH, pain and disability were reduced (SMD=-0.50, 95%CI-0.62 to -0.37; SMD=-0.71, 95%CI-1.17 to -0.24). Comparing acupuncture plus NPH with NPH alone, pain and disability were reduced (SMD=-0.70, 95%CI-0.94 to -0.46; SMD=-0.95, 95%CI-1.36 to -0.54). Comparing acupuncture plus PH with PH alone, pain and disability were reduced (MD=-0.21,8 95%CI-433.28 to -10.42; MD=-3.1, 95%CI-4.87 to -1.83). Comparing acupuncture plus combined treatment versus combined treatment alone, no differences were found in pain, while disability was reduced (MD=-3.40 95%CI-5.17 to -1.63). No studies assessed adverse event. Certainty of evidence ranged from moderate to very low. Conclusion We are uncertain whether acupuncture is more effective and safer than CT. In the comparisons without estimates’ imprecision, acupuncture showed promising results. Acupuncture could be an option based on patients’ preferences.
Effects of various prophylactic procedures on titanium surfaces and biofilm formation
Anna Di Salle,Gianrico Spagnuolo,Raffaele Conte,Alfredo Procino,Gianfranco Peluso,Carlo Rengo 대한치주과학회 2018 Journal of Periodontal & Implant Science Vol.48 No.6
Purpose: The aim of this study was to evaluate the effects of various prophylactic treatments of titanium implants on bacterial biofilm formation, correlating surface modifications with the biofilms produced by Pseudomonas aeruginosa PAO1, Staphylococcus aureus, and bacteria isolated from saliva. Methods: Pure titanium disks were treated with various prophylactic procedures, and atomic force microscopy (AFM) was used to determine the degree to which surface roughness was modified. To evaluate antibiofilm activity, we used P. aeruginosa PAO1, S. aureus, and salivaisolated Streptococcus spp., Bacteroides fragilis, and Staphylococcus epidermidis. Results: AFM showed that the surface roughness increased after using the air-polishing device and ultrasonic scaler, while a significant reduction was observed after using a curette or polishing with Detartrine ZTM (DZ) abrasive paste. In addition, we only observed a significant (P<0.01) reduction in biofilm formation on the DZ-treated implant surfaces. Conclusion: In this study, both AFM and antibiofilm analyses indicated that using DZ abrasive paste could be considered as the prophylactic procedure of choice for managing peri-implant lesions and for therapy-resistant cases of periodontitis.