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RISS 인기검색어
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- 저자 : Deyong Zhang (검색결과 4 건)
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Sanrong Li,Jing Ma,Caiying Hu,Xing Zhang,Deyong Xiao,Lili Hao,Wenjun Xiao,Jichun Yang,Ling Hu,Xiaowei Liu,Minghui Dong,Duan Ma,Rensheng Liu 한국유방암학회 2018 Journal of breast cancer Vol.21 No.3
In this study, we used next-generation sequencing methods to screen 300 individuals for BRCA1 and BRCA2. A novel mutation (c.849dupT) in BRCA2 was identified in a female patient and her unaffected brothers. This mutation leads to the truncation of BRCA2 functional domains. Moreover, BRCA2 mRNA expression levels in mutation carriers are significantly reduced compared to noncarriers. Immunofluorescence and western blot assays showed that this mutation resulted in reduced BRCA2 protein expression. Thus, we identified a novel mutation that damaged the function and expression of BRCA2 in a family with breast cancer history. The pedigree analysis suggested that this mutation is strongly associated with familial breast cancer. Genetic counsellors suggest that mutation carriers in this family undergo routine screening for breast cancer, as well as other malignancies, such as prostate and ovarian cancer. The effects of this BRCA2 mutation on drug resistance should be taken into consideration during treatment.
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Bo Ma,Xiang-Dong Gao,Lin Wang,Yan-Xi Zhang,Nanfeng Zhang,Deyong You 대한기계학회 2021 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.35 No.6
During multi-layer single-pass additive manufacture based on gas metal arc welding, the formation of product surface is highly affected by the robot welding process status. The thermal history of the manufacturing process was recorded by a thermocouple, and the arc current was collected by a current sensor to investigate the relationship between arc current stability and manufacture workpiece surface formation. The empirical mode decomposition energy entropy of different Z as , which are related to the current stability and utilization of arc power, were calculated. The 3D geometric dimension information of the workpiece was scanned by a laser vision sensing system. Experimental results show the current signal of the arc can be used to assess process stability, current stability caused the temperature of the basement, and surface formation changed. The energy entropy of arc current increased with the increase of Z as . The unstable arc can take away much of the heat generated by the arc heat source leading to the increase of deposition height and side surface roughness.
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Interaction between Metalloporphyrins and Diazine Tautomers
Xu, Huiying,Wang, Wei,Zhu, Jianqing,Xu, Xiaolu,Zhang, Deyong Korean Chemical Society 2013 Bulletin of the Korean Chemical Society Vol.34 No.12
The interaction between metalloporphyrins and diazine tautomers was investigated using quantum chemistry method. The results showed that the metal atom in the metalloporphyrin was not coplanar with porphin ring, and zinc porphyrin has the most extent of its non-coplanar nature. The most stable complex in nine complexes was iron porphyrin. NBO analysis indicated that the interaction between the lone pair of electrons on the nitrogen atom and the unoccupied lone pair orbital of metal contributes significantly to the stability of the complexes. Through the conceptual DFT parameter and Fukui dual descriptor, the thermodynamic stability and reactivity of complexes were analyzed. The density difference function (DDF) analyzes were performed to explore the rearrangement of electronic density after the coordination interaction. NICS calculation indicated that metalloporphyrin aromaticity was reduced after the coordination interaction, and aromaticity of diazine tautomer was increased along direction vector of the coordination interaction force.
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Interaction between Metalloporphyrins and Diazine Tautomers
Huiying Xu,Wei Wang,Jianqing Zhu,Xiaolu Xu,Deyong Zhang 대한화학회 2013 Bulletin of the Korean Chemical Society Vol.34 No.12
The interaction between metalloporphyrins and diazine tautomers was investigated using quantum chemistry method. The results showed that the metal atom in the metalloporphyrin was not coplanar with porphin ring, and zinc porphyrin has the most extent of its non-coplanar nature. The most stable complex in nine complexes was iron porphyrin. NBO analysis indicated that the interaction between the lone pair of electrons on the nitrogen atom and the unoccupied lone pair orbital of metal contributes significantly to the stability of the complexes. Through the conceptual DFT parameter and Fukui dual descriptor, the thermodynamic stability and reactivity of complexes were analyzed. The density difference function (DDF) analyzes were performed to explore the rearrangement of electronic density after the coordination interaction. NICS calculation indicated that metalloporphyrin aromaticity was reduced after the coordination interaction, and aromaticity of diazine tautomer was increased along direction vector of the coordination interaction force.
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