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        Cdyl2-60aa encoded by CircCDYL2 accelerates cardiomyocyte death by blocking APAF1 ubiquitination in rats

        Deng Yunfei,Zeng Xiaochen,Lv Yifei,Qian Zhiyuan,Guo Peijie,Liu Yi,Chen Shaoliang 생화학분자생물학회 2023 Experimental and molecular medicine Vol.55 No.-

        The loss of cardiomyocytes (CMs) after myocardial infarction (MI) is widely acknowledged to initiate the development of heart failure (HF). Herein, we found that circCDYL2 (583 nt) derived from chromodomain Y-like 2 (Cdyl2) is significantly upregulated in vitro (oxygen-glucose deprivation (OGD)-treated CMs) and in vivo (failing heart post-MI) and can be translated into a polypeptide termed Cdyl2-60aa (~7 kDa) in the presence of internal ribosomal entry sites (IRES). Downregulation of circCDYL2 significantly decreased the loss of OGD-treated CMs or the infarcted area of the heart post-MI. Additionally, elevated circCDYL2 significantly accelerated CM apoptosis via Cdyl2-60aa. We then discovered that Cdyl2-60aa could stabilize protein apoptotic protease activating factor-1 (APAF1) and promote CM apoptosis; heat shock protein 70 (HSP70) mediated APAF1 degradation in CMs by ubiquitinating APAF1, which Cdyl2-60aa could competitively block. In conclusion, our work substantiated the claim that circCDYL2 could promote CM apoptosis via Cdyl2-60aa, which enhanced APAF1 stability by blocking its ubiquitination by HSP70, suggesting that it is a therapeutic target for HF post-MI in rats.

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        DETECTION AND RESTORATION OF NON-RADIAL VARIATION OVER FULL-DISK SOLAR IMAGES

        Yunfei Yang,Jiaben Lin,Song Feng,Hui Deng,Feng Wang,Kai-fan Ji 한국천문학회 2013 Journal of The Korean Astronomical Society Vol.46 No.5

        Full-disk solar images are provided by many solar telescopes around the world. However, the observed images show Non-Radial Variation (NRV) over the disk. In this paper, we propose algorithms for detecting distortions and restoring these images. For detecting NRV, the cross-correlation coefficients matrix of radial profiles is calculated and the minimum value in the matrix is defined as the Index of Non-radial Variation (INV). This index has been utilized to evaluate the H$\alpha$ images of GONG, and systemic variations of different instruments are obtained. For obtaining the NRV's image, a Multi-level Morphological Filter (MMF) is designed to eliminate structures produced by solar activities over the solar surface. Comparing with the median filter, the proposed filter is a better choice. The experimental results show that the effect of our automatic detection and restoration methods is significant for getting a flat and high contrast full-disk image. For investigating the effect of our method on solar features, structural similarity (SSIM) index is utilized. The high SSIM indices (close to 1) of solar features show that the details of the structures remain after NRV restoring.

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        Justicia kampotiana Benoist (Acanthaceae): a new record for the flora of Vietnam

        Do Van Hai,Nguyen Khac Khoi,Ritesh Kumar Choudhary,Deng Yunfei,이상진,이중구 한국식물분류학회 2016 식물 분류학회지 Vol.46 No.1

        Justicia kampotiana Benoist (Acanthaceae) is reported as a new record for the flora of Vietnam. This species differs from its allied species J. ingrata Benoist in having corolla outside pubescent, tubes slightly longer than limbs and considerably shorter petioles. Description, line drawing and color photographs are provided for species identification. Furthermore, a comparison of the diagnostic characters with those of related species is made.

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